Zobrazeno 1 - 10
of 67
pro vyhledávání: '"GSIS, glucose stimulated insulin secretion"'
Autor:
Siying Zhu, Matthew S. Tremblay, Sean B. Joseph, Seung Hyuk Choi, Mitch Hull, Weijun Shen, Valeria Marrocco, Sijia Li, Marta Diez Cunado, Ana M. Gamo, Tuan Tran, Jason Roland, Arnab K. Chatterjee, Qiangwei Fu, Van Nguyen-Tran, Nikki Rogers
Publikováno v:
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 11, Iss 12, Pp 3983-3993 (2021)
Acta Pharmaceutica Sinica B, Vol 11, Iss 12, Pp 3983-3993 (2021)
Unfolded protein response (UPR) is a stress response that is specific to the endoplasmic reticulum (ER). UPR is activated upon accumulation of unfolded (or misfolded) proteins in the ER's lumen to restore protein folding capacity by increasing the sy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c176a631b2a5bf8251732009aad27d09
http://europepmc.org/articles/PMC8727761
http://europepmc.org/articles/PMC8727761
Autor:
Johanna McChord, Katharina Ganss, Christian Krautz, Sebastian Hempel, Klaus-Peter Knoch, Michele Solimena, Robert Grützmann, Philippe Ravassard, Kamal Chowdhury, Jürgen Weitz, Stephan Kersting, Christian Pilarsky, Hassan Mziaut, Steffen Wolk, Georg Henniger
Publikováno v:
Molecular metabolism
Molecular metabolism, Elsevier, 2020, 31, pp.150-162. ⟨10.1016/j.molmet.2019.11.012⟩
Molecular Metabolism, Vol 31, Iss, Pp 150-162 (2020)
Molecular Metabolism
Mol. Metab. 31, 150-162 (2020)
Molecular metabolism, Elsevier, 2020, 31, pp.150-162. ⟨10.1016/j.molmet.2019.11.012⟩
Molecular Metabolism, Vol 31, Iss, Pp 150-162 (2020)
Molecular Metabolism
Mol. Metab. 31, 150-162 (2020)
Objective MicroRNAs (miRNAs) play an integral role in maintaining beta cell function and identity. Deciphering their targets and precise role, however, remains challenging. In this study, we aimed to identify miRNAs and their downstream targets invol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ac233ce670f178447662777e657c669
https://doi.org/10.1016/j.molmet.2019.11.012
https://doi.org/10.1016/j.molmet.2019.11.012
Autor:
Katleen Lemaire, Abhijit Babaji Shinde, Stefan Vinckier, Frans Schuit, Ritesh K. Baboota, Marc Fransen, Paul P. Van Veldhoven, Myriam Baes
Publikováno v:
Molecular Metabolism, Vol 22, Iss, Pp 71-83 (2019)
Molecular Metabolism
Molecular Metabolism
Objectives Peroxisomes play a crucial role in lipid and reactive oxygen species metabolism, but their importance for pancreatic β-cell functioning is presently unknown. To examine the contribution of peroxisomal metabolism to β-cell homeostasis in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5a12bcfecad16b8dd47f4992e6fe7f4
http://www.sciencedirect.com/science/article/pii/S2212877818311153
http://www.sciencedirect.com/science/article/pii/S2212877818311153
Publikováno v:
Molecular Metabolism, Vol 49, Iss, Pp 101193-(2021)
Molecular Metabolism
Molecular Metabolism
Objective While the molecular events controlling insulin secretion from β-cells have been documented in detail, the exact mechanisms governing glucagon release by α-cells are understood only partially. This is a critical knowledge gap, as the norma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a321c33d9157f31ec647cb80b3e219fe
http://www.sciencedirect.com/science/article/pii/S2212877821000338
http://www.sciencedirect.com/science/article/pii/S2212877821000338
Autor:
Nada Mohamed, Ting Zhang, Justin Molitoris, Krishna Prasadan, Mohamed Saleh, Yan Wang, Anuradha Sehrawat, Ranjeet Kalsi, Madison Thomas, George K. Gittes
Publikováno v:
The Journal of Biological Chemistry
Understanding signaling pathways that regulate pancreatic β-cell function to produce, store, and release insulin, as well as pathways that control β-cell proliferation, is vital to find new treatments for diabetes mellitus. Transforming growth fact
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bf2363f38cde8af23f109fca39a28ff
https://pubmed.ncbi.nlm.nih.gov/34582892
https://pubmed.ncbi.nlm.nih.gov/34582892
Autor:
Carlos Castaño, Gema Alcarraz-Vizán, Marcelina Párrizas, Sara de Pablo, Júlia Rodríguez-Comas, Joan-Marc Servitja, Mario Vallejo, Antonio Fernández-Pérez, Sara Ramírez, Daniela Díaz-Catalán, Anna Novials, Marc Claret
Publikováno v:
Molecular Metabolism
Digital.CSIC. Repositorio Institucional del CSIC
instname
Molecular Metabolism, Vol 53, Iss, Pp 101251-(2021)
Digital.CSIC. Repositorio Institucional del CSIC
instname
Molecular Metabolism, Vol 53, Iss, Pp 101251-(2021)
© 2021 The Author(s).
[Objective]: Pancreatic β-cell dysfunction is a central feature in the pathogenesis of type 2 diabetes (T2D). Accumulating evidence indicates that β-site APP-cleaving enzyme 2 (BACE2) inhibition exerts a beneficial effec
[Objective]: Pancreatic β-cell dysfunction is a central feature in the pathogenesis of type 2 diabetes (T2D). Accumulating evidence indicates that β-site APP-cleaving enzyme 2 (BACE2) inhibition exerts a beneficial effec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7198fe332721e3e3ed6c3444b9e281b
http://europepmc.org/articles/PMC8190493
http://europepmc.org/articles/PMC8190493
Autor:
Abdullateef Isiaka Alagbonsi, Sheu Oluwadare Sulaiman, Abdul-Musawwir Alli-Oluwafuyi, Mayowa Adewale Iyanda, T.M. Salman
Publikováno v:
Metabolism Open
Metabolism Open, Vol 10, Iss, Pp 100092-(2021)
Metabolism Open, Vol 10, Iss, Pp 100092-(2021)
Background Telfairia occidentalis (TO), a plant consumed for its nutritional and medicinal values, exhibits hypoglycaemic effect. However, the metabolic fate of the glucose following TO-induced insulin secretion and consequent hypoglycaemia is not cl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7bc17558013eef5bf8a7552374f232b
http://europepmc.org/articles/PMC8095178
http://europepmc.org/articles/PMC8095178
Publikováno v:
Molecular Metabolism
Molecular Metabolism, Vol 53, Iss, Pp 101267-(2021)
Molecular Metabolism, 53
Molecular Metabolism, Vol 53, Iss, Pp 101267-(2021)
Molecular Metabolism, 53
Objective The miR-200–Zeb1 axis regulates the epithelial-to-mesenchymal transition (EMT), differentiation, and resistance to apoptosis. A better understanding of these processes in diabetes is highly relevant, as β-cell dedifferentiation and apopt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab341477b37288c8277923e83df480a8
https://pubmed.ncbi.nlm.nih.gov/34116231
https://pubmed.ncbi.nlm.nih.gov/34116231
Publikováno v:
The Journal of Biological Chemistry
The adipocyte hormone leptin regulates glucose homeostasis both centrally and peripherally. A key peripheral target is the pancreatic β-cell, which secretes insulin upon glucose stimulation. Leptin is known to suppress glucose-stimulated insulin sec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::657efb9fa07c0c0ee62cf426ba189d5c
http://europepmc.org/articles/PMC8010710
http://europepmc.org/articles/PMC8010710
Autor:
Kyle S. McCommis, Jerry R. Colca, Dakota R. Kamm, Laura N. Healy, Martin C. Sharpe, Kelly D. Pyles
Publikováno v:
The Journal of Biological Chemistry
Insulin sensitizers and incretin mimetics are antidiabetic agents with vastly different mechanisms of action. Thiazolidinedione (TZD) insulin sensitizers are associated with weight gain, whereas glucagon-like peptide-1 receptor agonists can induce we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be842022a0f9bc0e85ea8d47048c5426
https://pubmed.ncbi.nlm.nih.gov/34022222
https://pubmed.ncbi.nlm.nih.gov/34022222