Zobrazeno 1 - 10
of 542
pro vyhledávání: '"GSIS"'
Publikováno v:
Frontiers in Endocrinology, Vol 14 (2023)
The pancreas plays a critical role in maintaining glucose homeostasis through the secretion of hormones from the islets of Langerhans. Glucose-stimulated insulin secretion (GSIS) by the pancreatic β-cell is the main mechanism for reducing elevated p
Externí odkaz:
https://doaj.org/article/8bd6aa3267604bab80d7df16bfbcc1c3
Autor:
Xiaodi Zhao, Dohee Ahn, Gibeom Nam, Jihee Kwon, Songyi Song, Min Ji Kang, Hyejin Ahn, Sang J. Chung
Publikováno v:
Nutrients, Vol 15, Iss 22, p 4774 (2023)
Crocin, a glycoside of crocetin, has been known as the principal component responsible for saffron’s antidiabetic, anticancer, and anti-inflammatory effects. Crocetin, originating from the hydrolytic cleavage of crocin in biological systems, was su
Externí odkaz:
https://doaj.org/article/51f6aeaaeb824cb59305f20d853204c6
Autor:
Johan Perrier, Margaux Nawrot, Anne-Marie Madec, Karim Chikh, Marie-Agnès Chauvin, Christian Damblon, Julia Sabatier, Charles H. Thivolet, Jennifer Rieusset, Gilles J. P. Rautureau, Baptiste Panthu
Publikováno v:
Nutrients, Vol 15, Iss 22, p 4791 (2023)
Progressive decline in pancreatic beta-cell function is central to the pathogenesis of type 2 diabetes (T2D). Here, we explore the relationship between the beta cell and its nutritional environment, asking how an excess of energy substrate leads to a
Externí odkaz:
https://doaj.org/article/341a53787e7045499d77bf2dda2c0387
Akademický článek
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Characterization of human islet function in a convection‐driven intravascular bioartificial pancreas
Autor:
Ana G. Santandreu, Parsa Taheri‐Tehrani, Benjamin Feinberg, Alonso Torres, Charles Blaha, Rebecca Shaheen, Jarrett Moyer, Nathan Wright, Gregory L. Szot, William H. Fissell, Shant Vartanian, Andrew Posselt, Shuvo Roy
Publikováno v:
Bioengineering & Translational Medicine, Vol 8, Iss 2, Pp n/a-n/a (2023)
Abstract Clinical islet transplantation for treatment of type 1 diabetes (T1D) is limited by the shortage of pancreas donors and need for lifelong immunosuppressive therapy. A convection‐driven intravascular bioartificial pancreas (iBAP) based on h
Externí odkaz:
https://doaj.org/article/0675fe5c6d8140268bd6b9cb8205c8bc
DR-5 and DLL-4 mAb Functionalized SLNs of Gamma-Secretase Inhibitors- An Approach for TNBC Treatment
Publikováno v:
Advanced Pharmaceutical Bulletin, Vol 11, Iss 4, Pp 618-623 (2021)
Triple-negative breast cancer (TNBC) is the most aggressive and heterogeneous cancer subtypes. High rates of metastasis, poor prognosis, and drug resistance are the major problems associated with TNBC. The current chemotherapeutics eliminate only the
Externí odkaz:
https://doaj.org/article/8afe7cec2da54dd687f6b7865caa33ab
Akademický článek
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Autor:
Maria Pelullo, Sabrina Zema, Mariangela De Carolis, Samantha Cialfi, Maria Valeria Giuli, Rocco Palermo, Carlo Capalbo, Giuseppe Giannini, Isabella Screpanti, Saula Checquolo, Diana Bellavia
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Colorectal cancer (CRC) is characterized by early metastasis, resistance to anti-cancer therapy, and high mortality rate. Despite considerable progress in the development of new treatment options that improved survival benefits in patients with early
Externí odkaz:
https://doaj.org/article/5a75d1d611384d85bb357cc8053ec92e
Autor:
Hai-Ming Xu, Meng-Yu Wu, Xin-Chen Shi, Ke-Liang Liu, Ying-Chi Zhang, Yin-Feng Zhang, Hong-Mei Li
Publikováno v:
Toxics, Vol 11, Iss 2, p 174 (2023)
This study aimed to investigate the effects of perfluorooctanesulfonic acid (PFOS) exposure on glucose-stimulated insulin secretion (GSIS) of rat insulinoma (INS-1) cells and the potential protective effects of procyanidins (PC). The effects of PFOS
Externí odkaz:
https://doaj.org/article/8ab955a3ab4349efa1d6929389bc61a6
Publikováno v:
Diabetes, Metabolic Syndrome and Obesity, Vol Volume 13, Pp 509-520 (2020)
Chunyan Liu, Yanan Hao, Fei Yin, Jianhui Liu Chongqing Key Laboratory of Medicinal Chemistry & Molecular Pharmacology, Chongqing University of Technology, Chongqing 400054, People’s Republic of ChinaCorrespondence: Jianhui Liu; Fei YinChongqing Key
Externí odkaz:
https://doaj.org/article/e0cc8a58a8c0423cafd32b5da2bc7589