Miltirone induces cell death in hepatocellular carcinoma cell through GSDME-dependent pyroptosis

Autor: Ping Zhang, Dingyuan Ma, Li-Ying Peng, Ning-Yuan Sun, Jun Chen, Xiao-Wei Zhang, Weiwei Tang, Lin An

Publikováno v: Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 10, Iss 8, Pp 1397-1413 (2020)

Pyroptosis is a form of programmed cell death, and recently described as a new molecular mechanism of chemotherapy drugs in the treatment of tumors. Miltirone, a derivative of phenanthrene-quinone isolated from the root of Salvia miltiorrhiza Bunge,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::750fb5bad337ad6389f2c3000e4927a2
http://europepmc.org/articles/PMC7488361

A rapid increase in lysophospholipids after geranylgeranoic acid treatment in human hepatoma-derived HuH-7 cells revealed by metabolomics analysis

Autor: Chieko Iwao, Yoshihiro Shidoji

Publikováno v: Biochemistry and Biophysics Reports, Vol 28, Iss, Pp 101176-(2021)
Biochemistry and Biophysics Reports

Geranylgeranoic acid (GGA) was developed as a preventative agent against second primary hepatoma, and was reported to induce cell death in human hepatoma cells via Toll-like receptor 4 (TLR4)-mediated pyroptosis. We recently reported that GGA is enzy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fa6ea725b0c62a36ff8752da18e9ba4
http://www.sciencedirect.com/science/article/pii/S2405580821002703

Targeting the Inflammasome in Cardiovascular Disease

Autor: Marina Sokolova, Kaspar Broch, Kuan Yang, Bente Halvorsen, Maria Belland Olsen, Ida Gregersen, Øystein Sandanger, Lars Gullestad, Pål Aukrust, Mieke C. Louwe

Publikováno v: JACC: Basic to Translational Science

Highlights • Development of cardiovascular disease and inflammation are heavily intertwined, and inflammasome activation is thought play an important role in this interaction. • This review provides an overview of preclinical and clinical studies

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19ed38e9693e2ae09a73268b109a7b4f
http://hdl.handle.net/10852/91606

Caspase-11-Mediated Hepatocytic Pyroptosis Promotes the Progression of Nonalcoholic Steatohepatitis

Autor: Kai Lin, Han Zhao, Yingwei Zhu, Hong Tang, Gaojue Wu, Jingbin Ni, Jian Lu

Publikováno v: Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 2, Pp 653-664 (2021)

Background Nonalcoholic steatohepatitis (NASH) is an inflammatory disease with severe outcomes. Hepatocyte death, including apoptosis, necrosis, and pyroptosis, has been implicated in pathophysiology of NASH. Pyroptosis is mediated by inflammasome ac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49a531e474fb341f938e85d007e91df7
https://pubmed.ncbi.nlm.nih.gov/33894425

Ivermectin, a potential anticancer drug derived from an antiparasitic drug

Autor: Fuying Cheng, Wei Zhang, Jiangyan Li, Qiang Fang, Yi Wang, Xiaodong Hu, Chenying Yu, Mingyang Tang, Xin Yao

Publikováno v: Pharmacological Research

Graphical abstract Ivermectin has powerful antitumor effects, including the inhibition of proliferation, metastasis, and angiogenic activity, in a variety of cancer cells. This may be related to the regulation of multiple signaling pathways by iverme

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2883eaa6524499fe31b05214b7abbc0f
http://europepmc.org/articles/PMC7505114