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Akademický článek

Evaluation of allergenic properties and immunotoxicity of dipeptide mimetic of brain-derived neurotrophic factor GSB-106

Autor: L. P. Kovalenko, K. V. Korzhova, R. V. Zhurikov, C. B. Nikitin, A. D. Durnev

Publikováno v: Фармакокинетика и Фармакодинамика, Vol 0, Iss 1, Pp 30-33 (2020)

Abstract. The study of allergenic properties and immunotoxic effects of the ready-to-use drug form of GSB-106 was carried out. The study of allergenic properties and immunotoxicity of GSB-106 was performed on male albino guinea pigs weighing 250-300

Externí odkaz: https://doaj.org/article/b92e0e7552194e398dd1939259242d4e

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Akademický článek

Screening study of nerve growth factor's and brain-derived neurotrophic factor's mimetics effects at the experimental depression model

Autor: A. G. Mezhlumyan, A. V. Tallerova, P. Yu. Povarnina, N. M. Sazonova, A. V. Tarasiuk, T. A. Gudasheva

Publikováno v: Фармакокинетика и Фармакодинамика, Vol 0, Iss 1, Pp 11-17 (2020)

At the Zakusov Institute of Pharmacology designed and synthesized dimeric dipeptide mimetics of the 1st (GK-6) and 4th (GK-2) nerve growth factor loops, 1st (GSB-214), 2nd (GTS-201) and 4th (GSB -106, GSB-106Ac) brain-derived neurotrophic factor loop

Externí odkaz: https://doaj.org/article/d4dfcd3deb5448cbb115f2500a9500cc

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Akademický článek

Antidepressant-like activity of the dipeptide mimetic of brain-derived neurotrophic factor GSB-106 in Porsolt test after intraperitoneal sub-chronically and chronically treatment in mice

Autor: A. V. Tallerova, P. Y. Povarnina, S. V. Minaev, T. A. Gudasheva, S. B. Seredenin

Publikováno v: Фармакокинетика и Фармакодинамика, Vol 0, Iss 4, Pp 24-27 (2020)

The present work was to study the GSB-106 effect on the immobility behavior of mice Balb/c in the Porsolt test. GSB-106 was administered sub-chronically and chronically intraperitoneal in dose 1 mg/kg. GSB-106 administration significantly decreased i

Externí odkaz: https://doaj.org/article/939c43bd5c2443acbb8ec661169269b6

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Akademický článek

Comparison of neuroprotective properties of the dipeptide mimetics of the 1st, 2nd and 4th loops of the brain-derived neurotrophic factor on the model oxidative stress in vitro

Autor: I. O. Logvinov, A. V. Tarasiuk, N. M. Sazonova, P. I. Antipov, T. A. Antipova, T. A. Gudasheva

Publikováno v: Фармакокинетика и Фармакодинамика, Vol 0, Iss 3, Pp 37-41 (2019)

Resume. The purpose of this study was to compare neuroprotective properties of the dimeric dipeptide mimetics of the 1st, 2nd and 4th Loops of BDNF - GSB-214 (heptamethylenediamide bis-monosuccinyl-methionyl-serine), GTS-201 (hexamethylenediamide bis

Externí odkaz: https://doaj.org/article/ba8f1b738db242b4ae2c28656f8ed374

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Akademický článek

The study of the acute and chronic toxicity dipeptide mimetic of brain-derived neurotrophic factor GSB-106 finished dosage form

Autor: S. V. Alekseeva, A. V. Sorokina, A. V. Volkova, V. V. Zabrodina, I. A. Miroshkina, K. S. Kachalov, I. V. Alekseev, A. D. Zaharov, P. Yu. Povarnina, A. D. Durnev

Publikováno v: Фармакокинетика и Фармакодинамика, Vol 0, Iss 2, Pp 46-50 (2019)

Resume. The study of acute and chronic toxicity of the finished dosage form (SFF) GSB-106, the active substance of which is the substituted dimeric peptide, hexamethylenediamine bis (N-monosuccinyl-L-seryl-L-lysine), which has antidepressant and neur

Externí odkaz: https://doaj.org/article/e0abd8e20ff84910a7ef8e1979857f06

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Akademický článek

Pharmacokinetics of dipeptide mimetic BDNF GSB-106 in rats

Autor: V. P. Zherdev, G. B. Kolyvanov, A. A. Litvin, P. O. Bochkov, O. G. Gribakina, R. V. Shevchenko, A. V. Tarasyuk, T. A. Gudasheva

Publikováno v: Фармакокинетика и Фармакодинамика, Vol 0, Iss 1, Pp 37-43 (2019)

Pharmacokinetics of the GSB-106 in variety of administration ways in rats was studied. After single oral administration the test substance was determined for 4 h in the blood plasma. Half-life was 0.65 h. The GSB-106 tissue availability in high-vascu

Externí odkaz: https://doaj.org/article/f9523c8602544937afbc06cc38a61eb9

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Akademický článek

A study of neuroprotective effect stereospecificity of dipeptide mimetic of the Brain-derived neurotrophic factor GSB-106 on the model oxidative stress in the culture hippocampal cell line HT-22

Autor: I. O. Logvinov, A. V. Tarasiuk, P. I. Antipov, T. A. Antipova

Publikováno v: Фармакокинетика и Фармакодинамика, Vol 0, Iss 3, Pp 30-33 (2017)

In the present work, the neuroprotective effect stereospecificity of dimeric dipeptide mimetic of the 4th loop of BDNF-GSB-106 is studied. Activity of its diastereomers GT-106DL (hexamethylenediamide bis-monosuccinyl-D-seryl-L-lysine) and GT-106LD (h

Externí odkaz: https://doaj.org/article/a4843905917f4ef298863c4659dbb8ef

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Akademický článek

Low-Molecular Weight BDNF Mimetic, Dimeric Dipeptide GSB-106, Reverses Depressive Symptoms in Mouse Chronic Social Defeat Stress

Autor: Tatiana A. Gudasheva, Anna V. Tallerova, Armen G. Mezhlumyan, Tatyana A. Antipova, Ilya O. Logvinov, Yulia N. Firsova, Polina Y. Povarnina, Sergey B. Seredenin

Publikováno v: Biomolecules, Vol 11, Iss 2, p 252 (2021)

A mimetic of the BDNF loop 4, bis (N-monosuccinyl-L-seryl-L-lysine) hexamethylenediamide, named GSB-106, was designed and synthesized in our scientific group. The compound activated TrkB, MAPK/ERK, PI3K/AKT, and PLCγ in in vitro experiments. In vivo

Externí odkaz: https://doaj.org/article/fd6b301f445d496195370eaf3ae8921a

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