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Klotho and smoking - An interplay influencing the skeletal muscle function deficits that occur in COPD

Autor: Michael I. Polkey, Y.M. Andersson, Sonya Jackson, Nicholas Hart, Nicholas S Hopkinson, Anna Donaldson, Amy Lewis, Piet L.B. Bruijnzeel, Brian Bolognese, Joseph P. Foley, Mehul S. Patel, Jy Lee, Patricia L. Podolin, GS Haji, Paul R. Kemp, William D.-C. Man, Samantha A. Natanek

Publikováno v: Patel, M S, Donaldson, A V, Lewis, A, Natanek, S A, Lee, J Y, Andersson, Y M, Haji, G, Jackson, S G, Bolognese, B J, Foley, J P, Podolin, P L, Bruijnzeel, P L B, Hart, N, Hopkinson, N S, D-C Man, W, Kemp, P R & Polkey, M I 2016, ' Klotho and smoking-An interplay influencing the skeletal muscle function deficits that occur in COPD ', Respiratory Medicine . https://doi.org/10.1016/j.rmed.2016.02.004

Background Klotho is an ‘anti-ageing' hormone and transmembrane protein; Klotho deficient mice develop a similar ageing phenotype to smokers including emphysema and muscle wasting. The objective of this study was to evaluate skeletal muscle and cir

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be1de696e67dd0a7d8309a7fb78eab7e
https://kclpure.kcl.ac.uk/ws/files/46992266/1_s2.0_S0954611116300221_main.pdf

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S49 Ventilatory irregularity quantified by approximate entropy identifies disordered breathing in patients with unexplained dyspnoea: Abstract S49 Table 1

Autor: Harry B. Rossiter, GS Haji, James H. Hull, Michael I. Polkey, T Bansal

Publikováno v: Thorax. 70:A31.1-A31

Introduction Patients with idiopathic persistent exertional dyspnoea are often labelled as having a breathing pattern disorder (BPD). There are no agreed objective diagnostic measures for BPD, which complicates its characterisation and response to th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::79d555cd35bb11bff1dd4bd4738336b3
https://doi.org/10.1136/thoraxjnl-2015-207770.55

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Dynamic laryngeal narrowing in COPD may have effects on the trachea

Autor: Michael I. Polkey, GS Haji, James H. Hull

Publikováno v: Thorax. 70:692-692

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::65e4eb949f6c82e322fa6b7fbb806f1a
https://doi.org/10.1136/thoraxjnl-2015-206953

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P47 Continuous Laryngoscopy During Exercise (cle): A Practical And Valuable Test In A Respiratory Service?

Autor: Andrew Menzies-Gow, James H. Hull, GS Haji, B Panchasara, Simon Ward

Publikováno v: Thorax. 69:A94-A94

Introduction and rationale Exertional wheeze and dyspnoea are most frequently attributed to exercise induced bronchoconstriction (EIB), yet may arise secondarily to a temporary closure of the larynx. This condition, termed Exercise induced laryngeal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a54cdc01b7e393a7e8fd7b5643716dee
https://doi.org/10.1136/thoraxjnl-2014-206260.188

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P67 Laryngeal Narrowing In Chronic Obstructive Pulmonary Disease (copd): A Mechanism For Generating Intrinsic Peep?

Autor: Andrew Menzies-Gow, GS Haji, Rebecca Tanner, Nicholas S Hopkinson, James H. Hull, Michael I. Polkey, M Baz

Publikováno v: Thorax. 69:A104-A104

Introduction and rationale Patients with COPD often exhibit pursed lip breathing during exercise, a strategy to help overcome a rise in intrinsic PEEP secondary to dynamic hyperinflation. A similar role for laryngeal closure to optimise respiratory m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6e33e375a728423183ef344742cf3d02
https://doi.org/10.1136/thoraxjnl-2014-206260.208

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P189 Mitochondrial dysfunction in muscle and airway compartments in COPD: preliminary findings

Autor: Michael I. Polkey, GS Haji, Fan Chung, Ian M. Adcock, Coen Wiegman, Paul R. Kemp, Meera Patel

Publikováno v: Thorax. 68:A161.2-A162

Introduction & Rationale Oxidative stress may underlie both pulmonary and non-pulmonary manifestations of COPD and may result from mitochondrial dysfunction. We hypothesised that if oxidative stress arose from the lung and ‘spilled over’ to cause

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8b037ba371d3d50fc6cff924fd61ccd3
https://doi.org/10.1136/thoraxjnl-2013-204457.341

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