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of 3 939
pro vyhledávání: '"GRP78"'
Autor:
Keiji Fujimoto, Hiroki Adachi, Serina Kita, Megumi Sakuma, Hirotaka Yamanouchi, Sho Kumano, Ai Fujii, Keita Yamazaki, Keiichiro Okada, Norifumi Hayashi, Kengo Furuichi
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract The estimated glomerular filtration rate (eGFR) at 1 year post-transplantation is a well-established predictor of long-term graft survival; however, its predictive accuracy needs improvement. We retrospectively analyzed data from 51 kidney t
Externí odkaz:
https://doaj.org/article/218b271492f648e78d1317aa252779c6
Autor:
Michela Murdocca, Osvaldo Andrade Santos-Filho, Claudia De Masi, Edivaldo dos Santos Rodrigues, Claudia Valeria Campos de Souza, Riccardo De Santis, Donatella Amatore, Andrea Latini, Rossella Schipani, Lino di Rienzo Businco, Bruno Brandimarte, Giorgia Grilli, Tien L Huang, Annie S Mayence, Florigio Lista, Andrea Duranti, Federica Sangiuolo, Jean Jacques Vanden Eynde, Giuseppe Novelli
Publikováno v:
Biology Direct, Vol 19, Iss 1, Pp 1-14 (2024)
Abstract The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is reliably one of the largest pandemics the world has suffered in recent years. In the search for non-biological antivirals, special emphasis was placed on drug repurposing to
Externí odkaz:
https://doaj.org/article/22eadf0fa2714ca38385e40ea9142bcb
Publikováno v:
Biomarker Research, Vol 12, Iss 1, Pp 1-28 (2024)
Abstract Non-alcoholic fatty liver disease (NAFLD), a spectrum of liver conditions characterized by fat accumulation without excessive alcohol consumption, represents a significant global health burden. The intricate molecular landscape underlying NA
Externí odkaz:
https://doaj.org/article/bb26b4a213044d598e7adefcd567fb40
Autor:
Yang Chen, Hengyang Shen, Zhenling Wang, Changzhi Huang, Hongqiang Zhang, Yu Shao, Ying Tong, Lei Xu, Yunfei Lu, Zan Fu
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 43, Iss 1, Pp 1-17 (2024)
Abstract Background Long-term accumulation of misfolded proteins leads to endoplasmic reticulum (ER) stress in colorectal cancer (CRC). However, the precise pathways controlling the decision between survival and apoptosis in CRC are unclear. Therefor
Externí odkaz:
https://doaj.org/article/654c8e7a60d0478cbf43e94e7c6e84d1
Publikováno v:
BMC Pediatrics, Vol 24, Iss 1, Pp 1-10 (2024)
Abstract Background Newborns are exposed to varying degrees of stressful interventions due to procedures such as heel lancing used in routine metabolic screenings. It is an examination of the effects of white noise and kangaroo care on some physiolog
Externí odkaz:
https://doaj.org/article/e606acd6f0a44320a48ec86e6506ad44
Autor:
Dat P. Ha, Woo-Jin Shin, Ze Liu, Michael E. Doche, Roy Lau, Nektaria Maria Leli, Crystal S. Conn, Mariangela Russo, Annalisa Lorenzato, Constantinos Koumenis, Min Yu, Shannon M. Mumenthaler, Amy S. Lee
Publikováno v:
Cell & Bioscience, Vol 14, Iss 1, Pp 1-25 (2024)
Abstract Background Despite recent therapeutic advances, combating cancer resistance remains a formidable challenge. The 78-kilodalton glucose-regulated protein (GRP78), a key stress-inducible endoplasmic reticulum (ER) chaperone, plays a crucial rol
Externí odkaz:
https://doaj.org/article/41b097963d3a4f95bc528fc71d41ad9c
Autor:
Wannapa Sornjai, Ploenphit Promma, Suphansa Priewkhiew, Suwipa Ramphan, Janejira Jaratsittisin, Pailin Jinagool, Nitwara Wikan, Michael Greenwood, David Murphy, Duncan R. Smith
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-18 (2024)
Abstract Glucose regulated protein 78 (GRP78) is a chaperone protein that is a central mediator of the unfolded protein response, a key cellular stress response pathway. GRP78 has been shown to be critically required for infection and replication of
Externí odkaz:
https://doaj.org/article/c5f2c5cf13904bb5a996078ab7873faa
Publikováno v:
Regulatory Mechanisms in Biosystems, Vol 15, Iss 2, Pp 367-373 (2024)
Endoplasmic reticulum stress (ER stress) activates the unfolded protein response (UPR) as a defense mechanism for maintaining cellular vital activity. Data on interaction between pathways of UPR-sensors, their role and participation in the recovery o
Externí odkaz:
https://doaj.org/article/ae7d1bc9a9334e80be713605e34b015a
Akademický článek
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Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 55, Iss , Pp 101020- (2024)
The 78-kDa glucose regulated protein (GRP78) commonly upregulated in a wide variety of tumors is an important prognostic marker and a promising target for suppressing tumorigenesis and treatment resistance. While GRP78 is well established as a major
Externí odkaz:
https://doaj.org/article/0ba66393413a49c9bdfc0cfc40caaeb8