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pro vyhledávání: '"GRK2"'
Akademický článek
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Autor:
Mark T. Waddingham, Hirotsugu Tsuchimochi, Takashi Sonobe, Vasco Sequeira, Md Junayed Nayeem, Mikiyasu Shirai, James T. Pearson, Takeshi Ogo
Publikováno v:
Journal of Molecular and Cellular Cardiology Plus, Vol 8, Iss , Pp 100072- (2024)
Background: Pulmonary hypertension (PH) often leads to right ventricle (RV) failure, a significant cause of morbidity and mortality. Despite advancements in PH management, progression to RV maladaptation and subsequent failure remain a clinical chall
Externí odkaz:
https://doaj.org/article/c799fd064dab4b7da859a49b8d77c099
Publikováno v:
Drug Design, Development and Therapy, Vol Volume 18, Pp 71-80 (2024)
Giselle Del Calvo, Celina M Pollard, Teresa Baggio Lopez, Jordana I Borges, Malka S Suster, Anastasios Lymperopoulos Laboratory for the Study of Neurohormonal Control of the Circulation, Department of Pharmaceutical Sciences (Pharmacology), Barry and
Externí odkaz:
https://doaj.org/article/e94eac979d3240cd84145f79c3505448
Autor:
Xuezhi Yang, Yingjie Zhao, Qi Wei, Xuemin Zhu, Luping Wang, Wankang Zhang, Xiaoyi Liu, Jiajie Kuai, Fengling Wang, Wei Wei
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 14, Iss 1, Pp 241-255 (2024)
Rheumatoid arthritis (RA) is an autoimmune disease with a complex etiology. Monocyte-derived macrophages (MDMs) infiltration are associated with RA severity. We have reported the deletion of G-protein-coupled receptor kinase 2 (GRK2) reprograms macro
Externí odkaz:
https://doaj.org/article/f6639b3b6e3047ac96e86736878025d0
Autor:
Siqi Wang, Chengsi Zhang, Huali Hu, Jianxia Xu, Jinxin Zhang, Wu Zhou, Fahua Deng, Yaming Zhang, Chenlong Hu, Yuancheng Liu, Hai Huang, Sixi Wei
Publikováno v:
Frontiers in Bioscience-Landmark, Vol 29, Iss 10, p 362 (2024)
Background: A long non-coding RNAs (LncRNAs) called antisense noncoding RNA in the INK4 locus (ANRIL), has emerged as substantial regulators of cell survival in acute myeloid leukemia (AML). However, its speciffc and potential mechanism is uncertain
Externí odkaz:
https://doaj.org/article/db26cf3a504644e59697ac32888226f6
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 17, p 9644 (2024)
GRK2 and arrestin3, key players in the functional regulation of G protein-coupled receptors (GPCRs), are ubiquitinated by Mdm2, a nuclear protein. The agonist-induced increase in arrestin3 ubiquitination occurs in the nucleus, underscoring the crucia
Externí odkaz:
https://doaj.org/article/3200257c31c947ea95333e90bfd0ac5d
Autor:
Shuen-Hsin Liu, Fong-Jhih Lin, Yu-Hsun Kao, Pao-Huan Chen, Yung-Kuo Lin, Yen-Yu Lu, Yao-Chang Chen, Yi-Jen Chen
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 14, p 7619 (2024)
Sleep deprivation (SD) is a recognized risk factor for atrial fibrillation (AF), yet the precise molecular and electrophysiological mechanisms behind SD-induced AF are unclear. This study explores the electrical and structural changes that contribute
Externí odkaz:
https://doaj.org/article/44200b9fc0c64954adf8f92461a79ff4
Autor:
Seungmin Ham, Saori Mukaida, Masaaki Sato, Peter Keov, Tore Bengtsson, Sebastian Furness, Nicholas D. Holliday, Bronwyn A. Evans, Roger J. Summers, Dana S. Hutchinson
Publikováno v:
Pharmacology Research & Perspectives, Vol 12, Iss 1, Pp n/a-n/a (2024)
Abstract Truncation of the C‐terminal tail of the β2‐AR, transfection of βARKct or over‐expression of a kinase‐dead GRK mutant reduces isoprenaline‐stimulated glucose uptake, indicating that GRK is important for this response. We explored
Externí odkaz:
https://doaj.org/article/8b05f72e8cfe40dba5549ad1377f554f
Autor:
Asma S. Alonazi, Anfal F. Bin Dayel, Danah A. Albuaijan, Alhanouf S. Bin Osfur, Fatemah M. Hakami, Shaden S. Alzayed, Ahmad R. Almotairi, Mohammad R. Khan, Hana M. Alharbi, Rehab A. Ali, Maha A. Alamin, Hanan K. Alghibiwi, Nouf M. Alrasheed, Khaled A. Alhosaini
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 24, p 17270 (2023)
Pathological cardiac remodeling is associated with cardiovascular disease and can lead to heart failure. Nuclear factor-kappa B (NF-κB) is upregulated in the hypertrophic heart. Moreover, the expression of the G-protein-coupled receptor kinase 2 (GR
Externí odkaz:
https://doaj.org/article/5f09f330d1e74532be0e1edaf9a006df