Zobrazeno 1 - 10
of 19
pro vyhledávání: '"GRK (G protein-coupled receptor kinase)"'
Publikováno v:
Frontiers in Molecular Biosciences, Vol 11 (2024)
Externí odkaz:
https://doaj.org/article/026e4b553f4144019a1b103dda3cce3f
Publikováno v:
The Journal of Biological Chemistry
WHIM syndrome is a rare immunodeficiency disorder that is characterized by warts, hypogammaglobulinemia, infections, and myelokathexis. While several gain-of-function mutations that lead to C-terminal truncations, frame shifts and point mutations in
Autor:
Jonathan A. Javitch, Wesley B. Asher, Jennifer Pham, Asuka Inoue, Maria Hauge Pedersen, Helena Mancebo
Publikováno v:
The Journal of Biological Chemistry
Pedersen, M H, Pham, J, Mancebo, H, Inoue, A, Asher, W B & Javitch, J A 2021, ' A novel luminescence-based β-arrestin recruitment assay for unmodified receptors ', Journal of Biological Chemistry, vol. 296, 100503 . https://doi.org/10.1016/j.jbc.2021.100503
Pedersen, M H, Pham, J, Mancebo, H, Inoue, A, Asher, W B & Javitch, J A 2021, ' A novel luminescence-based β-arrestin recruitment assay for unmodified receptors ', Journal of Biological Chemistry, vol. 296, 100503 . https://doi.org/10.1016/j.jbc.2021.100503
G protein-coupled receptors (GPCRs) signal through activation of G proteins and subsequent modulation of downstream effectors. More recently, signaling mediated by β-arrestin has also been implicated in important physiological functions. This has le
Autor:
Ivan Silbern, Henning Urlaub, Reinhard Jahn, Kuan-Ting Pan, Stefan Bonn, Maksims Fiosins, Silvio O. Rizzoli, Eugenio F. Fornasiero
Publikováno v:
Molecular & Cellular Proteomics : MCP
Molecular and Cellular Proteomics
Molecular & cellular proteomics 20, 100061-(2021). doi:10.1016/j.mcpro.2021.100061
Molecular and Cellular Proteomics
Molecular & cellular proteomics 20, 100061-(2021). doi:10.1016/j.mcpro.2021.100061
Synaptic transmission is mediated by the regulated exocytosis of synaptic vesicles. When the presynaptic membrane is depolarized by an incoming action potential, voltage-gated calcium channels open, resulting in the influx of calcium ions that trigge
Publikováno v:
The Journal of Biological Chemistry
For most G protein-coupled receptors, the third intracellular loop (IL3) and carboxy-terminal tail (CT) are sites for G protein-coupled receptor kinase (GRK)-mediated phosphorylation, leading to β-arrestin binding and agonist-specific desensitizatio
Autor:
Vaibhav Dhyani, Sarpras Swain, Rishikesh Kumar Gupta, Suman Gare, Kareenhalli V. Venkatesh, Lopamudra Giri
Publikováno v:
Cellular Signalling
G-protein coupled receptor (GPCR) mediated calcium (Ca2+)-signaling transduction remains crucial in designing drugs for various complex diseases including neurodegeneration, chronic heart failure as well as respiratory diseases. Although there are se
Publikováno v:
JACC: Basic to Translational Science
Summary The new horizon for cardiac therapy may lie beneath the surface, with the downstream mediators of G protein–coupled receptor (GPCR) activity. Targeted approaches have shown that receptor activation may be biased toward signaling through G p
Autor:
Kishalay Mitra, Priyanka Devi Pantula, Ajith Karunarathne, Dinesh Kankanamge, Lopamudra Giri, Mithila Tennakoon, Sithurandi Ubeysinghe
Publikováno v:
The Journal of Biological Chemistry
Phospholipase C β (PLCβ), which is activated by the Gq family of heterotrimeric G proteins, hydrolyzes the inner membrane lipid phosphatidylinositol 4,5-bisphosphate (PIP2), generating diacylglycerol and inositol 1,4,5-triphosphate (IP3). Because G
Akademický článek
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Autor:
Misun, Park, Susan F, Steinberg
Publikováno v:
JACC: Basic to Translational Science
Visual Abstract
Highlights • Oxidative stress induced by acute H2O2 or chronic doxorubicin treatment leads to a decrease in β1AR expression and isoproterenol responsiveness in cardiomyocytes. • The redox-dependent disruption of the β1AR si
Highlights • Oxidative stress induced by acute H2O2 or chronic doxorubicin treatment leads to a decrease in β1AR expression and isoproterenol responsiveness in cardiomyocytes. • The redox-dependent disruption of the β1AR si