Zobrazeno 1 - 10
of 216
pro vyhledávání: '"GREGORY S. KORBUTT"'
Autor:
Purushothaman Kuppan, Jordan Wong, Sandra Kelly, Jiaxin Lin, Jessica Worton, Chelsea Castro, Joy Paramor, Karen Seeberger, Nerea Cuesta-Gomez, Colin C. Anderson, Gregory S. Korbutt, Andrew R. Pepper
Publikováno v:
Pharmaceutics, Vol 15, Iss 9, p 2201 (2023)
One strategy to prevent islet rejection is to create a favorable immune-protective local environment at the transplant site. Herein, we utilize localized cyclosporine A (CsA) delivery to islet grafts via poly(lactic-co-glycolic acid) (PLGA) micropart
Externí odkaz:
https://doaj.org/article/16b9bbccce744ae580602897ab1613e8
Autor:
Christos Karampelias, Habib Rezanejad, Mandy Rosko, Likun Duan, Jing Lu, Laura Pazzagli, Philippe Bertolino, Carolyn E. Cesta, Xiaojing Liu, Gregory S. Korbutt, Olov Andersson
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Regeneration of insulin-producing beta-cells may become a future alternative treatment of diabetes. Here the authors report a genetic screen in a zebrafish model that mimics the loss of beta-cells in diabetes, and identified that the folate receptor
Externí odkaz:
https://doaj.org/article/a728a4a3f5614b2a9d19997422e58055
Autor:
Kateryna Polishevska, Sandra Kelly, Purushothaman Kuppan, Karen L. Seeberger, Saloni Aggarwal, Joy Paramor, Larry D. Unsworth, Hubert M. Tse, Gregory S. Korbutt, Andrew R. Pepper
Publikováno v:
Pharmaceutics, Vol 15, Iss 4, p 1137 (2023)
Beta cell replacement therapies can restore glycemic control to select individuals living with type 1 diabetes. However, the obligation of lifelong immunosuppression restricts cell therapies from replacing exogenous insulin administration. Encapsulat
Externí odkaz:
https://doaj.org/article/66a636e3137441e39325b8f3f61481b3
Autor:
Purushothaman Kuppan, Sandra Kelly, Karen Seeberger, Chelsea Castro, Mandy Rosko, Andrew R. Pepper, Gregory S. Korbutt
Publikováno v:
Polymers, Vol 14, Iss 6, p 1120 (2022)
The subcutaneous space is currently being pursued as an alternative transplant site for ß-cell replacement therapies due to its retrievability, minimally invasive procedure and potential for graft imaging. However, implantation of ß-cells into an u
Externí odkaz:
https://doaj.org/article/778e324b93664d6dbe777656522524c0
Publikováno v:
Cell Transplantation, Vol 25 (2016)
One challenge that must be overcome to allow transplantation of neonatal porcine islets (NPIs) to become a clinical reality is defining a reproducible and scalable protocol for the efficient preparation of therapeutic quantities of clinical grade NPI
Externí odkaz:
https://doaj.org/article/6bb46849b34d463682a523652c710521
Autor:
Hossein Arefanian, Eric B. Tredget, Dereck C. M. Mok, Qahir Ramji, Shahin Rafati, Jose Rodriguez-Barbosa, Gregory S. Korbutt, Ray V. Rajotte, Ron G. Gill, Gina R. Rayat
Publikováno v:
Cell Transplantation, Vol 25 (2016)
We previously demonstrated that short-term administration of a combination of anti-LFA-1 and anti-CD154 monoclonal antibodies (mAbs) induces tolerance to neonatal porcine islet (NPI) xenografts that is mediated by regulatory T cells (Tregs) in B6 mic
Externí odkaz:
https://doaj.org/article/e37508f4d8514156a2575938b0824f41
Autor:
Tsunehiro Kobayashi, Hossein Arefanian, George Harb, Eric B. Tredget, Ray V. Rajotte, Gregory S. Korbutt, Gina R. Rayat
Publikováno v:
Cell Transplantation, Vol 17 (2008)
Several studies have demonstrated that in vitro culture of islets prolonged islet graft survival in immune-competent mice without administration of antirejection drugs. However, we recently showed that in vitro cultured microencapsulated neonatal por
Externí odkaz:
https://doaj.org/article/ce36837084fb42b5a3e95e43d6d2356e
Autor:
Jannette M. Dufour, Brinda Dass, Katie R. Halley, Gregory S. Korbutt, Doreen E. Dixon, Ray V. Rajotte
Publikováno v:
Cell Transplantation, Vol 17 (2008)
Sertoli cells are important for maintenance of the immune privileged environment of the testis and prolong survival of cotransplanted cells. The objective of the current study was to examine the immunoprotective properties of a mouse Sertoli cell lin
Externí odkaz:
https://doaj.org/article/43b0575ae3174df9944f98b13129e2a5
Autor:
Jannette M. Dufour, Sarah J. Lord, Tatsuya Kin, Gina R. Rayat, Doreen E. Dixon, R. Chris Bleackley, Gregory S. Korbutt, Ray V. Rajotte
Publikováno v:
Cell Transplantation, Vol 16 (2007)
Sertoli cells (SC) protect islet allografts from immune destruction in diabetic rodents. In this study, we examined the difference between successful and rejected islet/SC cografts in order to further improve this procedure for optimal extension of i
Externí odkaz:
https://doaj.org/article/cea3cf4bf4154abe957e60494bfd0bed
Autor:
Hossein Arefanian, Eric B. Tredget, Ray V. Rajotte, Gregory S. Korbutt, Ron G. Gill, Gina R. Rayat
Publikováno v:
Cell Transplantation, Vol 16 (2007)
Type 1 diabetes mellitus (T1DM) is caused by the autoimmune destruction of pancreatic islet β-cells, which are required for the production of insulin. Islet transplantation has been shown to be an effective treatment option for T1DM; however, the cu
Externí odkaz:
https://doaj.org/article/ea492de575504fa9a0e62eb473b36ba7