Zobrazeno 1 - 10
of 72
pro vyhledávání: '"GREGORY M. COLE"'
Autor:
Katsuya Sakimura, Takashi Kawai, Reiko Nashida, Yuji Ishida, Kana Harada, Takashi Suzuki, Chihiro Okuma, Gregory M. Cole
Publikováno v:
Alzheimer’s Research & Therapy, Vol 16, Iss 1, Pp 1-15 (2024)
Abstract Background Alzheimer’s disease (AD) is the most common form of dementia. Although drugs focusing on reducing amyloid β slow progression, they fail to improve cognitive function. Deficits in glucose metabolism are reflected in FDG-PET and
Externí odkaz:
https://doaj.org/article/d0cd1b22ce1843a987fdf8ace4913d23
Autor:
Susan A. Greenfield, Gregory M. Cole, Clive W. Coen, Sally Frautschy, Ram P. Singh, Marisa Mekkittikul, Sara Garcia‐Ratés, Paul Morrill, Owen Hollings, Matt Passmore, Sibah Hasan, Nikisha Carty, Silvia Bison, Laura Piccoli, Renzo Carletti, Stephano Tacconi, Anna Chalidou, Matthew Pedercini, Tim Kroecher, Hubert Astner, Philip A. Gerrard
Publikováno v:
Alzheimer’s & Dementia: Translational Research & Clinical Interventions, Vol 8, Iss 1, Pp n/a-n/a (2022)
Abstract Introduction The neuronal mechanism driving Alzheimer's disease (AD) is incompletely understood. Methods Immunohistochemistry, pharmacology, biochemistry, and behavioral testing are employed in two pathological contexts—AD and a transgenic
Externí odkaz:
https://doaj.org/article/07684a389acc417a9545fbf1b57c644f
Autor:
Susan Adele Greenfield, Giovanni Ferrati, Clive W. Coen, Auguste Vadisiute, Zoltan Molnár, Sara Garcia-Rates, Sally Frautschy, Gregory M. Cole
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 21, p 13119 (2022)
The substantia nigra is generally considered to show significant cell loss not only in Parkinson’s but also in Alzheimer’s disease, conditions that share several neuropathological traits. An interesting feature of this nucleus is that the pars co
Externí odkaz:
https://doaj.org/article/ad5a244148ea4760b25e50d36404d206
Autor:
Qiu-Lan Ma, Cansheng Zhu, Marco Morselli, Trent Su, Matteo Pelligrini, Zhengqi Lu, Mychica Jones, Paul Denver, Daniel Castro, Xuelin Gu, Frances Relampagos, Kaitlin Caoili, Bruce Teter, Sally A. Frautschy, Gregory M. Cole
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Neuroinflammation plays a crucial role in the development and progression of Alzheimer's disease (AD), in which activated microglia are found to be associated with neurodegeneration. However, there is limited evidence showing how neuroinflammation an
Externí odkaz:
https://doaj.org/article/bdb572081193451080868c064d87e8c1
Autor:
Qiu-Lan Ma, Edmond Teng, Xiaohong Zuo, Mychica Jones, Bruce Teter, Evan Y. Zhao, Cansheng Zhu, Tina Bilousova, Karen H. Gylys, Liana G. Apostolova, Mary Jo LaDu, Mir Ahamed Hossain, Sally A. Frautschy, Gregory M. Cole
Publikováno v:
Neurobiology of Disease, Vol 114, Iss , Pp 120-128 (2018)
Synaptic neurodegeneration is thought to be an early event initiated by soluble β-amyloid (Aβ) aggregates that closely correlates with cognitive decline in Alzheimer disease (AD). Apolipoprotein ε4 (APOE4) is the most common genetic risk factor fo
Externí odkaz:
https://doaj.org/article/20a092811af24e62af1f42edd4697829
Autor:
Edmond Teng, Karen Taylor, Tina Bilousova, David Weiland, Thaidan Pham, Xiaohong Zuo, Fusheng Yang, Ping-Ping Chen, Charles G. Glabe, Alison Takacs, Dennis R. Hoffman, Sally A. Frautschy, Gregory M. Cole
Publikováno v:
Neurobiology of Disease, Vol 82, Iss , Pp 552-560 (2015)
Increased dietary consumption of docosahexaenoic acid (DHA) is associated with decreased risk for Alzheimer's disease (AD). These effects have been postulated to arise from DHA's pleiotropic effects on AD pathophysiology, including its effects on β-
Externí odkaz:
https://doaj.org/article/437fd4e36b6a4589a46d2998dc8ccc84
Autor:
Kristy S. Hwang, Andreas S. Lazaris, Jennifer A. Eastman, Edmond Teng, Paul M. Thompson, Karen H. Gylys, Gregory M. Cole, Liana G. Apostolova, Alzheimer's Disease Neuroimaging Initiative
Publikováno v:
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 1, Iss 2, Pp 187-193 (2015)
Abstract Background Brain‐derived neurotrophic factor (BDNF) plays an important role in Alzheimer's disease (AD) and other neurodegenerative disorders. BDNF function is adversely affected by amyloid beta in AD. BDNF levels in brain and peripheral t
Externí odkaz:
https://doaj.org/article/e31b9276a6ce4b15827daa2eaa632fe4
Autor:
Tina Bilousova, Karen Taylor, Ana Emirzian, Raymond Gylys, Sally A. Frautschy, Gregory M. Cole, Edmond Teng
Publikováno v:
Neurobiology of Disease, Vol 74, Iss , Pp 32-40 (2015)
Neuronal pentraxin receptor (NPR) is a synaptic protein implicated in AMPA receptor trafficking at excitatory synapses. Since glutamate neurotransmission is disrupted in Alzheimer's disease (AD), NPR levels measured from plasma represent a potential
Externí odkaz:
https://doaj.org/article/35d2fbc50c5c4f6aa457be6c4da3a2e9
Autor:
Edmond Teng, Vladimir Kepe, Sally A. Frautschy, Jie Liu, Nagichettiar Satyamurthy, Fusheng Yang, Ping-Ping Chen, Graham B. Cole, Mychica R. Jones, Sung-Cheng Huang, Dorothy G. Flood, Stephen P. Trusko, Gary W. Small, Gregory M. Cole, Jorge R. Barrio
Publikováno v:
Neurobiology of Disease, Vol 43, Iss 3, Pp 565-575 (2011)
In vivo detection of Alzheimer's disease (AD) neuropathology in living patients using positron emission tomography (PET) in conjunction with high affinity molecular imaging probes for β-amyloid (Aβ) and tau has the potential to assist with early di
Externí odkaz:
https://doaj.org/article/eda7aa183a7f4f13948348dcbfe53217
Autor:
Michael E. Jung, Dale E. Bredesen, Chris Jean Elias, Dongsheng Bai, Chunni Zhu, Mary Jo LaDu, Gregory M. Cole, Johnny Pham, Patricia Spilman, Michael Jun, Jesus Campagna, Jagodzinska Barbara, Asa Hatami, Tina Bilousova, Varghese John
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-15 (2018)
Scientific reports, vol 8, iss 1
Scientific Reports
Scientific reports, vol 8, iss 1
Scientific Reports
We describe here the results from the testing of a small molecule first-in-class apolipoprotein E4 (ApoE4)-targeted sirtuin1 (SirT1) enhancer, A03, that increases the levels of the neuroprotective enzyme SirT1 while not affecting levels of neurotoxic