Fetal hemoglobin levels in sickle cell disease and normal individuals are partially controlled by an X-linked gene located at Xp22.2

Autor: GR Serjeant, Abbie C. Mays, Kirby D. Smith, C Sheils, Yen Pei C. Chang, DA Meyers, Shirley H. Purvis, George J. Dover

Publikováno v: Blood. 80:816-824

Fetal hemoglobin (Hb F) production in sickle cell (SS) disease and in normal individuals varies over a 20-fold range and is under genetic control. Previous studies suggested that variant Hb F levels might be controlled by genetic loci separate from t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c7f3262b936d2f38155d6d8b65aab640
https://doi.org/10.1182/blood.v80.3.816.bloodjournal803816

Production of F cells in sickle cell anemia: regulation by a genetic locus or loci separate from the beta-globin gene cluster

Autor: SH Boyer, GJ Dover, GR Serjeant, KD Smith, SE Antonarakis, SH Embury, L Margolet, AN Noyes, ML Boyer, WB Bias

Publikováno v: Blood. 64(5)

Levels of fetal hemoglobin (HbF) bearing reticulocytes (F reticulocytes) range from 2% to 50% in patients with sickle cell (SS) anemia. To learn whether any portion of such variation in F cell production is regulated by loci genetically separable fro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e83648e1370efaf8a9b904ff4ef66157
https://pubmed.ncbi.nlm.nih.gov/6207872

The molecular basis of alpha thalassemia in India. Its interaction with the sickle cell gene

Autor: AE Kulozik, BC Kar, GR Serjeant, BE Serjeant, DJ Weatherall

Publikováno v: Blood. 71(2)

The alpha globin genotype of a total of 282 Indians from Orissa state has been analyzed. The overall alpha thalassemia gene frequency is 0.29, most frequently caused by the -alpha 3.7 and -alpha 4.2 deletions. In one family a novel -alpha 3.5 deletio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6649208284aa84987378c33ff609c23
https://pubmed.ncbi.nlm.nih.gov/2827816

Homozygous sickle cell disease in Uganda and Jamaica a comparison of Bantu and Benin haplotypes

Autor: Ndugwa C, Higgs D, Fisher C, Ian Hambleton, Mason K, Be, Serjeant, Gr, Serjeant

Publikováno v: Europe PubMed Central

To compare the haematological and clinical features of homozygous sickle cell (SS) disease in Bantu and Benin haplotypes in a cross-sectional study of 115 Ugandan patients attending the Sickle Cell Clinic at Mulago Hospital, Kampala, Uganda, with 311

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::316442c1d41ce7409bef23c09983a23e
http://europepmc.org/abstract/med/23620965

The beta thalassaemia trait in Jamaica.

Autor: Serjeant GR; Sickle Cell Trust, 14 Milverton Cres, Kingston 6, Jamaica. grserjeant@gmail.com., Serjeant BE; Sickle Cell Trust, 14 Milverton Cres, Kingston 6, Jamaica., Mason KP; Sickle Cell Trust, 14 Milverton Cres, Kingston 6, Jamaica., Gibson F; Sickle Cell Trust, 14 Milverton Cres, Kingston 6, Jamaica., Gardner RA; Sickle Cell Trust, 14 Milverton Cres, Kingston 6, Jamaica., Warren L; Sickle Cell Trust, 14 Milverton Cres, Kingston 6, Jamaica., Reid M; Faculty of Medical Sciences, University of the West Indies, Mona, Kingston 7, Jamaica., Happich M; Department of Pediatric Oncology, Hematology and Immunology, University of Heidelberg, Heidelberg, Germany., Kulozik AE; Department of Pediatric Oncology, Hematology and Immunology, University of Heidelberg, Heidelberg, Germany.

Publikováno v: Journal of community genetics [J Community Genet] 2023 Aug; Vol. 14 (4), pp. 355-360. Date of Electronic Publication: 2023 Jun 30.