Výsledky vyhledávání - "GR, Glutathione reductase"

Oxidative stress and apoptotic effects of copper and cadmium in the zebrafish liver cell line ZFL

Publikováno v: Toxicology Reports, Vol 7, Iss, Pp 822-835 (2020)
Toxicology Reports

Graphical abstract
Highlights • Oxidative stress and apoptosis created by Cu2+ and Cd2+ insults were studied in ZFL. • Cu2+ and Cd2+ both created lipid peroxidation, causing oxidative stress in cytoplasm. • Mitochondrial superoxide was ind

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0402719444dde34edacafe8222a5be9
http://www.sciencedirect.com/science/article/pii/S2214750020303474

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Cinnamomum zeylanicum Blume (Ceylon cinnamon) bark extract attenuates doxorubicin induced cardiotoxicity in Wistar rats

Autor: Lakmini Mudduwa, Kamani Ayoma Perera Wijewardana Jayatilaka, Jayasinghe Arachchige Nirosha Sandamali, Ruwani Punyakanthi Hewawasam

Publikováno v: Saudi Pharmaceutical Journal, Vol 29, Iss 8, Pp 820-832 (2021)
Saudi Pharmaceutical Journal : SPJ

Anti-tumour efficacy of doxorubicin is hindered by the cumulative dose-dependent cardiotoxicity induced by reactive oxygen species during its metabolism. As Cinnamomum zeylanicum has proven antioxidant potential, objective of this study was to invest

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07ec834331604e75cffd6b67e9822c83
http://www.sciencedirect.com/science/article/pii/S1319016421001183

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Doxorubicin-induced alterations in kidney functioning, oxidative stress, DNA damage, and renal tissue morphology; Improvement by Acacia hydaspica tannin-rich ethyl acetate fraction

Autor: Suhail Razak, Ali Almajwal, Tayyaba Afsar, Dara Al-Disi

Publikováno v: Saudi Journal of Biological Sciences, Vol 27, Iss 9, Pp 2251-2260 (2020)
Saudi Journal of Biological Sciences

Doxorubicin (DOX) is an anthracycline drug used for cancer treatment. However, its treatment is contiguous with toxic effects. We examine the nephroprotective potential of A. hydaspica polyphenol-rich ethyl acetate extract (AHE) against DOX persuaded

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89d76d10a2004f5cf7b12979a7290a99
http://www.sciencedirect.com/science/article/pii/S1319562X20303028

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Cinnamon oil against acetaminophen-induced acute liver toxicity by attenuating inflammation, oxidative stress and apoptosis

Autor: Saeed Alshahrani, Fakhrul Islam, Rahimullah Siddiqui, Mohammed Ashafaq, Rayan A Ahmed, Sohail Hussain, Gulrana Khuwaja

Publikováno v: Toxicology Reports
Toxicology Reports, Vol 7, Iss, Pp 1296-1304 (2020)

Graphical abstract
Acetaminophen (APAP) is used as a primary drug due to its antipyretic and analgesic activity. The mechanism of action of APAP toxicity in the liver is due to the depletion of glutathione which elicited free radicals generation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ccb153456c1b85f9ee1f88a05b7acd1
http://europepmc.org/articles/PMC7528057

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Protective effect of a polyherbal bioactive fraction in propylthiouracil-induced thyroid toxicity in ratsby modulation of the hypothalamic–pituitary–thyroid and hypothalamic–pituitary–adrenal axes

Autor: S Sudhamani, Vandana S. Panda, Sneha Singh, Payal Dande

Publikováno v: Toxicology Reports
Toxicology Reports, Vol 7, Iss, Pp 730-742 (2020)

Graphical abstract
Highlights • Hypothyroidism is the most frequent toxic effect of a large variety of chemical compounds. • The polyherbal bioactive fraction exhibited a pro-thyroid effect in hypothyroidic rats. • The polyherbal fraction

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58a037e2fd9e28edc68e1ec8b7e6fd1a
http://europepmc.org/articles/PMC7301176

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Insights into the ameliorative effect of oleic acid in rejuvenating phenylhydrazine induced oxidative stress mediated morpho-functionally dismantled erythrocytes

Autor: Adrita Banerjee, Aindrila Chattopadhyay, Tiyasa Dey, Arnab Kumar Ghosh, Sanatan Mishra, Debasish Bandyopadhyay

Publikováno v: Toxicology Reports, Vol 7, Iss, Pp 1551-1563 (2020)
Toxicology Reports

Graphical abstract
Highlights • Phenylhydrazine induces structural and functional changes in erythrocytes. • Oleic acid ameliorates these changes possibly through its antioxidant mechanisms. • Oleic acid can be a benefitting molecule in co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0793744238a1cd482d4f34df74021edf
http://www.sciencedirect.com/science/article/pii/S2214750020304303

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Alternaria host-specific (HSTs) toxins: An overview of chemical characterization, target sites, regulation and their toxic effects

Autor: Swarnmala Samal, Mukesh Meena

Publikováno v: Toxicology Reports
Toxicology Reports, Vol 6, Iss, Pp 745-758 (2019)

Graphical abstract
Highlights • Alternaria is responsible to cause pathogenic diseases on several crops. • Alternaria species produce several types of host-specific and non-host-specific toxins. • HSTs have devastating effects on host plan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::487c975b3848480f404e9814d65eba01
http://europepmc.org/articles/PMC6684332

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The effect of voluntary wheel running on the antioxidant status is dependent on sociability conditions

Autor: Roberta de Paula Martins, Mauricio P. Cunha, Daniele G. Machado, Andreza Fabro de Bem, Alcir Luiz Dafre, Alexandra Latini, Gianni Mancini, Ana Lúcia S. Rodrigues, Viviane Glaser

Publikováno v: Pharmacology, Biochemistry, and Behavior

Voluntary wheel running is widely used as a physical activity (PA) model in rodents, but most studies investigate the beneficial effects of this intervention in socially isolated mice. Social isolation stress (SIS) is associated with vulnerability to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73edad96cb09a0f29cb25e077b695bbd
http://europepmc.org/articles/PMC7438373

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Amelioration of diethylnitrosamine (DEN) induced renal oxidative stress and inflammation by

Autor: Deepika, Singh, Deepak, Chaudhary, Vikas, Kumar, Amita, Verma

Publikováno v: Toxicology Reports

Graphical abstract
Highlights • Phytofabricated silver nanoparticles (CCAgNPs) were biosynthesized and characterized. • CCAgNPs were evaluated against diethylnitrosamine induced renal cancer. • Silver nanoparticles have an antioxidant prop

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::52a7eed13e3a072b5d2b6a4a74c30aff
https://pubmed.ncbi.nlm.nih.gov/33850732

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Inhibition and crosslinking of the selenoprotein thioredoxin reductase-1 by p-benzoquinone

Autor: Nan Shu, Qing Cheng, Elias S.J. Arnér, Michael J. Davies

Publikováno v: Shu, N, Cheng, Q, Arner, E S J & Davies, M J 2020, ' Inhibition and crosslinking of the selenoprotein thioredoxin reductase-1 by p-benzoquinone ', Redox Biology, vol. 28, 101335 . https://doi.org/10.1016/j.redox.2019.101335
Redox Biology
Redox Biology, Vol 28, Iss, Pp-(2020)

Quinones are common in nature, and often cytotoxic. Their proposed toxicity mechanisms involve redox cycling with radical generation, and/or reactions with nucleophiles, such as protein cysteine (Cys) residues, forming adducts via Michael addition re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::deff0ff237c1dbe23349174a540bc470
https://curis.ku.dk/portal/da/publications/inhibition-and-crosslinking-of-the-selenoprotein-thioredoxin-reductase1-by-pbenzoquinone(eca1d1e1-ad99-41d7-8ae2-ef2076fe9b7e).html

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