IL-1β-pre-conditioned mesenchymal stem/stromal cells’ secretome modulates the inflammatory response and aggrecan deposition in intervertebral disc

Autor: JR Ferreira, GQ Teixeira, E Neto, C Ribeiro-Machado, AM Silva, J Caldeira, C Leite Pereira, S Bidarra, AF Maia, M Lamghari, MA Barbosa, RM Gonçalves

Publikováno v: European Cells & Materials, Vol 41, Pp 431-453 (2021)

Mesenchymal stem/stromal cells (MSCs) have been increasingly used in clinical trials for low-back pain (LBP) and intervertebral disc (IVD) degeneration with promising results. Their action mechanisms are not fully understood, but they reduce IVD pro-

Externí odkaz: https://doaj.org/article/241b651246a84b049c2e6cac16d3ad03

Structure-function of cartilage in osteoarthritis: An ex-vivo correlation analysis between its structural, viscoelastic and frictional properties.

Autor: de Roy L; Institute of Orthopedic Research and Biomechanics, Center for Trauma Research, Ulm University Medical Center Ulm, Germany. Electronic address: luisa.de-roy@uni-ulm.de., Teixeira GQ; Institute of Orthopedic Research and Biomechanics, Center for Trauma Research, Ulm University Medical Center Ulm, Germany. Electronic address: graciosa.teixeira@uni-ulm.de., Schwer J; Institute of Orthopedic Research and Biomechanics, Center for Trauma Research, Ulm University Medical Center Ulm, Germany. Electronic address: jonas.schwer@uni-ulm.de., Sukopp M; Institute of Orthopedic Research and Biomechanics, Center for Trauma Research, Ulm University Medical Center Ulm, Germany. Electronic address: matthias.sukopp@uni-ulm.de., Faschingbauer M; Department of Orthopedic Surgery, RKU, Ulm University Medical Center, Ulm, Germany. Electronic address: martin.faschingbauer@rku.de., Ignatius A; Institute of Orthopedic Research and Biomechanics, Center for Trauma Research, Ulm University Medical Center Ulm, Germany. Electronic address: anita.ignatius@uni-ulm.de., Seitz AM; Institute of Orthopedic Research and Biomechanics, Center for Trauma Research, Ulm University Medical Center Ulm, Germany. Electronic address: andreas.seitz@uni-ulm.de.

Publikováno v: Acta biomaterialia [Acta Biomater] 2024 Oct 18. Date of Electronic Publication: 2024 Oct 18.

Analysis of Intervertebral Disc Degeneration Induced by Endplate Drilling or Needle Puncture in Complement C6-Sufficient and C6-Deficient Rabbits.

Autor: Kuhn A; Division for Biochemistry of Joint and Connective Tissue Diseases, Department of Orthopedics, Ulm University, 89081 Ulm, Germany., Huber-Lang M; Institute of Clinical and Experimental Trauma-Immunology, University Hospital Ulm, Ulm University, 89081 Ulm, Germany., Weckbach S; Department of Orthopedic Surgery, RKU, Ulm University, 89081 Ulm, Germany., Riegger J; Division for Biochemistry of Joint and Connective Tissue Diseases, Department of Orthopedics, Ulm University, 89081 Ulm, Germany., Teixeira GQ; Institute of Orthopedic Research and Biomechanics, Trauma Research Centre, Ulm University, 89081 Ulm, Germany., Rasche V; Department of Internal Medicine II, Ulm University, 89081 Ulm, Germany.; Core Facility Small Animal Imaging (CF-SANI), Ulm University, 89081 Ulm, Germany., Fiedler J; Division for Biochemistry of Joint and Connective Tissue Diseases, Department of Orthopedics, Ulm University, 89081 Ulm, Germany., Neidlinger-Wilke C; Institute of Orthopedic Research and Biomechanics, Trauma Research Centre, Ulm University, 89081 Ulm, Germany., Brenner RE; Division for Biochemistry of Joint and Connective Tissue Diseases, Department of Orthopedics, Ulm University, 89081 Ulm, Germany.

Publikováno v: Biomedicines [Biomedicines] 2024 Jul 30; Vol. 12 (8). Date of Electronic Publication: 2024 Jul 30.

Editorial: Intervertebral disc degeneration and osteoarthritis: mechanisms of disease and functional repair.

Autor: Teixeira GQ; Institute of Orthopaedic Research and Biomechanics, Trauma Research Centre, Ulm University, Ulm, Germany., Riegger J; Department of Orthopedics, Division for Biochemistry of Joint and Connective Tissue Diseases, Ulm University, Ulm, Germany., Gonçalves RM; Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal.; Instituto de Engenharia Biomédica, Universidade do Porto, Porto, Portugal.; Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto, Porto, Portugal., Risbud MV; Department of Orthopaedic Surgery, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, United States.; Graduate Program in Cell Biology and Regenerative Medicine, College of Life Sciences, Thomas Jefferson University, Philadelphia, PA, United States.

Publikováno v: Frontiers in bioengineering and biotechnology [Front Bioeng Biotechnol] 2023 Jul 26; Vol. 11, pp. 1252703. Date of Electronic Publication: 2023 Jul 26 (Print Publication: 2023).

Terminal Complement Activation Is Induced by Factors Released from Endplate Tissue of Disc Degeneration Patients and Stimulates Expression of Catabolic Enzymes in Annulus Fibrosus Cells.

Autor: Kuhn A; Division for Biochemistry of Joint and Connective Tissue Diseases, Department of Orthopedics, Ulm University, 89081 Ulm, Germany., Riegger J; Division for Biochemistry of Joint and Connective Tissue Diseases, Department of Orthopedics, Ulm University, 89081 Ulm, Germany., Teixeira GQ; Institute of Orthopedic Research and Biomechanics, Trauma Research Centre, Ulm University, 89081 Ulm, Germany., Huber-Lang M; Institute of Clinical and Experimental Trauma Immunology, University Hospital Ulm, 89081 Ulm, Germany., Lambris JD; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Neidlinger-Wilke C; Institute of Orthopedic Research and Biomechanics, Trauma Research Centre, Ulm University, 89081 Ulm, Germany., Brenner RE; Division for Biochemistry of Joint and Connective Tissue Diseases, Department of Orthopedics, Ulm University, 89081 Ulm, Germany.

Publikováno v: Cells [Cells] 2023 Mar 13; Vol. 12 (6). Date of Electronic Publication: 2023 Mar 13.