Zobrazeno 1 - 10
of 26
pro vyhledávání: '"GPx4, glutathione peroxidase 4"'
Autor:
Wenbin Huang, Lei Cai, Guolin He, Liang Zhao, Yishi Lu, Mingxin Pan, Donghui Zhang, Yuan Cheng, Hangyu Liao, Weimei Huang, Yujun Tang, Liuran Li, Kunling Chen
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 23, Iss 12, Pp 1227-1239 (2021)
Neoplasia (New York, N.Y.)
Neoplasia (New York, N.Y.)
Sorafenib is a first-line molecular-target drug for advanced hepatocellular carcinoma (HCC), and reducing sorafenib resistance is an important issue to be resolved for the clinical treatment of HCC. In the current study, we identified that ABCC5 is a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e7546a05995e276bc0a627d79310110
http://www.sciencedirect.com/science/article/pii/S1476558621000919
http://www.sciencedirect.com/science/article/pii/S1476558621000919
Autor:
Jun Huang, Ke Liu, Guido Kroemer, Changfeng Li, Borong Zou, Daolin Tang, Rui Kang, Jiao Liu, Herbert J. Zeh
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Philadelphia, PA : American Gastroenterological Association, [2015]-, 2022, 13 (2), pp.483-500. ⟨10.1016/j.jcmgh.2021.09.008⟩
Cellular and Molecular Gastroenterology and Hepatology, Vol 13, Iss 2, Pp 483-500 (2022)
Cellular and Molecular Gastroenterology and Hepatology, Philadelphia, PA : American Gastroenterological Association, [2015]-, 2022, 13 (2), pp.483-500. ⟨10.1016/j.jcmgh.2021.09.008⟩
Cellular and Molecular Gastroenterology and Hepatology, Vol 13, Iss 2, Pp 483-500 (2022)
Background & Aims Pancreatitis is characterized by acinar cell death and persistent inflammation. Ferroptosis is a type of lipid peroxidation-dependent necrosis, which is negatively regulated by glutathione peroxidase 4. We studied how trypsin, a ser
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2672294190e99060699bb76afc1e37a6
https://hal.sorbonne-universite.fr/hal-03549632/file/1-s2.0-S2352345X2100196X-main.pdf
https://hal.sorbonne-universite.fr/hal-03549632/file/1-s2.0-S2352345X2100196X-main.pdf
Autor:
Hongrui Guo, Yujuan Ouyang, Heng Yin, Hengmin Cui, Huidan Deng, Huan Liu, Zhijie Jian, Jing Fang, Zhicai Zuo, Xun Wang, Ling Zhao, Yanqiu Zhu, Yi Geng, Ping Ouyang
Publikováno v:
Redox Biology
Redox Biology, Vol 49, Iss, Pp 102227-(2022)
Redox Biology, Vol 49, Iss, Pp 102227-(2022)
Copper (Cu) is a necessary micronutrient at lower concentration, while excessive Cu exposure or Cu homeostasis disorders can lead to toxicity. The mechanism of male reproductive toxicity induced by Cu is still unknown. This study aims to investigate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::945b39456122ac6504ffcd21146f9cf4
https://pubmed.ncbi.nlm.nih.gov/34979450
https://pubmed.ncbi.nlm.nih.gov/34979450
Publikováno v:
Translational Oncology, Vol 14, Iss 11, Pp 101207-(2021)
Translational Oncology
Translational Oncology
Highlights • D5D is an independent prognostic factor in cancer. • D5D aggravates cancer progression via mediating AA/PGE2 production from DGLA. • AA/PGE2 promotes cancer progression via regulating the tumor microenvironment. • Inhibition of D
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c81cba5e09eeffe1477f02b7b3cd5fa8
http://www.sciencedirect.com/science/article/pii/S1936523321001996
http://www.sciencedirect.com/science/article/pii/S1936523321001996
Autor:
Shun Shen, Yang Wang, Yongbin Cao, Yao Liu, Huishu Guo, Xiaomin Su, Boshu Ouyang, Zhiqing Pang, Bo Ning
Publikováno v:
Materials Today Bio
Materials Today Bio, Vol 12, Iss, Pp 100154-(2021)
Materials Today Bio, Vol 12, Iss, Pp 100154-(2021)
Ferroptosis has received ever-increasing attention due to its unparalleled mechanism in eliminating resistant tumor cells. Nevertheless, the accumulation of toxic lipid peroxides (LPOs) at the tumor site is limited by the level of lipid oxidation. He
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a549112f9dd3359da733e0dcf1b6b5cb
https://pubmed.ncbi.nlm.nih.gov/34778741
https://pubmed.ncbi.nlm.nih.gov/34778741
Autor:
Wen-Xing Ding, Hartmut Jaeschke, David S Umbaugh, Olamide B. Adelusi, Giselle Sanchez-Guerrero, Nga T. Nguyen, Jephte Y. Akakpo, Anup Ramachandran
Publikováno v:
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 11, Iss 12, Pp 3740-3755 (2021)
Acta Pharmaceutica Sinica B, Vol 11, Iss 12, Pp 3740-3755 (2021)
Acetaminophen (APAP) is a widely used analgesic and antipyretic drug, which is safe at therapeutic doses but can cause severe liver injury and even liver failure after overdoses. The mouse model of APAP hepatotoxicity recapitulates closely the human
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bde30b76b24a28a9236a78a6ec2b0a30
https://pubmed.ncbi.nlm.nih.gov/35024303
https://pubmed.ncbi.nlm.nih.gov/35024303
Autor:
Nuria García-Magro, Cristina Fernández-Mendívil, Enrique Luengo, Paula Trigo-Alonso, Pilar Negredo, Manuela G. López
Publikováno v:
Redox Biology, Vol 38, Iss, Pp 101789-(2021)
Redox Biology
Redox Biology
Heme oxygenase-1 (HO-1) is an inducible enzyme known for its anti-inflammatory, antioxidant and neuroprotective effects. However, increased expression of HO-1 during aging and age-related neurodegenerative diseases have been associated to neurotoxic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43dfb34480f285e42eea2931b0cfeb92
http://www.sciencedirect.com/science/article/pii/S2213231720309940
http://www.sciencedirect.com/science/article/pii/S2213231720309940
Autor:
Kaylin M. McMahon, Adam Yuh Lin, Reem Karmali, Andrea E. Calvert, Shuo Yang, C. Shad Thaxton, Jonathan Moreira, Jonathan S. Rink, Amir Behdad, Tim Taxter, Amy Chadburn, Leo I. Gordon
Publikováno v:
The Journal of Biological Chemistry
Normal human cells can either synthesize cholesterol or take it up from lipoproteins to meet their metabolic requirements. In some malignant cells, de novo cholesterol synthesis genes are transcriptionally silent or mutated, meaning that cholesterol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7cb836b9ce6f454dd5dbd3c4704784a
http://europepmc.org/articles/PMC7949030
http://europepmc.org/articles/PMC7949030
Publikováno v:
Chinese Journal of Traumatology
Chinese Journal of Traumatology, Vol 25, Iss 1, Pp 1-10 (2022)
Chinese Journal of Traumatology, Vol 25, Iss 1, Pp 1-10 (2022)
Sepsis is a life-threatening clinical syndrome and one of the most challenging health problems in the world. Pathologically, sepsis and septic shock are caused by a dysregulated host immune response to infection, which can eventually lead to multiple
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58f78f03c1ea030072286a73467e72f2
https://pubmed.ncbi.nlm.nih.gov/34334261
https://pubmed.ncbi.nlm.nih.gov/34334261
Autor:
Hongquan Guo, Xinfeng Liu, Juanji Li, Xiaolei Shi, Yi Xie, Pengfei Xu, Yunzi Li, Qian Liu, Rui Sun, Ye Hong, Mengna Peng, Gelin Xu
Publikováno v:
Redox Biology
Redox Biology, Vol 18, Iss, Pp 158-172 (2018)
Redox Biology, Vol 18, Iss, Pp 158-172 (2018)
Cellular oxidative stress plays a vital role in the pathological process of neural damage in cerebral ischemia/reperfusion (I/R). The breast cancer susceptibility protein 1 (BRCA1), a tumor suppressor, can modulate cellular antioxidant response and D
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6e034e7c5102b1e7cd98f372f511aac
https://doi.org/10.1016/j.redox.2018.06.012
https://doi.org/10.1016/j.redox.2018.06.012