Zobrazeno 1 - 10
of 1 792
pro vyhledávání: '"GPVI"'
Platelet mass cytometry reveals dysregulation of prothrombotic pathways in essential thrombocythemia
Autor:
Veronika Dill, Kilian Kirmes, Jiaying Han, Melissa Klug, Marc Rosenbaum, Giacomo Viggiani, Moritz von Scheidt, Markus List, Peter Herhaus, Jürgen Ruland, Florian Bassermann, Karl-Ludwig Laugwitz, Katharina S. Götze, Philipp J. Jost, Stefanie Jilg, Conor J. Bloxham, Philip W.J. Raake, Isabell Bernlochner, Dario Bongiovanni
Publikováno v:
Platelets, Vol 35, Iss 1 (2024)
Thromboembolic events are common in patients with essential thrombocythemia (ET). However, the pathophysiological mechanisms underlying the increased thrombotic risk remain to be determined. Here, we perform the first phenotypical characterization of
Externí odkaz:
https://doaj.org/article/6b03b9ff955e40ae9ff5ee319c518d34
Akademický článek
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Autor:
Pankaj Kumar Singh, Carol A. Dangelmaier, Hymavathi Reddy Vari, Alexander Y. Tsygankov, Satya P. Kunapuli
Publikováno v:
Platelets, Vol 34, Iss 1 (2023)
Alternate splicing is among the regulatory mechanisms imparting functional diversity in proteins. Studying protein isoforms generated through alternative splicing is therefore critical for understanding protein functions in many biological systems. S
Externí odkaz:
https://doaj.org/article/59a190ce04fa438db5cc20248019132a
Autor:
Yujia Ye, Lihong Yang, Min Leng, Qian Wang, Jiankui Wu, Wen Wan, Huawei Wang, Longjun Li, Yunzhu Peng, Shengjie Chai, Zhaohui Meng
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Introduction: Luteolin inhibits platelet activation and thrombus formation, but the mechanisms are unclear. This study investigated the effects of luteolin on GPVI-mediated platelet activation in vitro and explored the effect of luteolin on thrombosi
Externí odkaz:
https://doaj.org/article/35814476f571474988fc4f292e3de25b
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 21, Iss , Pp 2873-2883 (2023)
Platelets play a vital role in cancer and immunity. However, few comprehensive studies have been conducted on the role of platelet-related signaling pathways in various cancers and their responses to immune checkpoint blockade (ICB) therapy. In the p
Externí odkaz:
https://doaj.org/article/f4c84acc36314b4db586c50e40e901aa
Autor:
Hilaire Yam Fung Cheung, Luis A. Moran, Albert Sickmann, Johan W.M. Heemskerk, Ángel Garcia, Steve P. Watson
Publikováno v:
Platelets, Vol 33, Iss 8, Pp 1293-1300 (2022)
Src tyrosine kinases and spleen tyrosine kinase (Syk) have recently been shown to contribute to sustained platelet aggregation on collagen under arterial shear. In the present study, we have investigated whether Src and Syk are required for aggregati
Externí odkaz:
https://doaj.org/article/658911ff2f36451db5cf428008920244
Publikováno v:
Platelets, Vol 33, Iss 7, Pp 1096-1099 (2022)
The platelet transmembrane receptor GPVI can be assessed together with other platelet membrane markers in a whole blood multicolor flow cytometry panel. The advantage of combining multiple antibodies in a single tube is the possibility of distinguish
Externí odkaz:
https://doaj.org/article/8f9fe7c2e11d40f0b1f7f3e1b58ec5af
Akademický článek
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Autor:
Iván Parra-Izquierdo, Alexander R. Melrose, Jiaqing Pang, Hari Hara Sudhan Lakshmanan, Stéphanie E. Reitsma, Sai Hitesh Vavilapalli, Mark K. Larson, Joseph J. Shatzel, Owen J. T. McCarty, Joseph E. Aslan
Publikováno v:
Platelets, Vol 33, Iss 3, Pp 404-415 (2022)
Several Janus kinase (JAK) inhibitors (jakinibs) have recently been approved to treat inflammatory, autoimmune and hematological conditions. Despite emerging roles for JAKs and downstream signal transducer and activator of transcription (STAT) protei
Externí odkaz:
https://doaj.org/article/39b1104d776a4aa682c0497f47e4622c