Zobrazeno 1 - 10
of 362
pro vyhledávání: '"GPR81"'
Publikováno v:
Cells, Vol 13, Iss 14, p 1177 (2024)
Believed for a long time to be merely a waste product of cell metabolism, lactate is now considered a molecule with several roles, having metabolic and signalling functions together with a new, recently discovered role as an epigenetic modulator. Lac
Externí odkaz:
https://doaj.org/article/771e25b88e19486cb58f10569d458487
Autor:
Xiaofeng li, Yiwen Chen, Ting Wang, Zifan Liu, Guotao Yin, Ziyang Wang, Chunxiao Sui, Lei Zhu, Wei Chen
Publikováno v:
Discover Oncology, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Background Local tumor microenvironment (TME) plays a crucial role in immunotherapy for breast cancer (BC). Whereas, the molecular mechanism responsible for the crosstalk between BC cells and surrounding immune cells remains unclear. The pre
Externí odkaz:
https://doaj.org/article/08eacdf1b69c4c4db60fc693ecdb338c
Publikováno v:
Nutrients, Vol 16, Iss 5, p 582 (2024)
The dysregulation of the intestinal epithelial barrier significantly contributes to the inflammatory progression of ulcerative colitis. Recent studies have indicated that lactate, produced by gut bacteria or derived from fermented foods, plays a key
Externí odkaz:
https://doaj.org/article/a604e751926e4ec298825e585713940c
Autor:
Jing Yang, Glenn R. Gourley, Adam Gilbertsen, Chi Chen, Lei Wang, Karen Smith, Marion Namenwirth, Libang Yang
Publikováno v:
Cells, Vol 13, Iss 3, p 236 (2024)
Hyperglycemia, lipotoxicity, and insulin resistance are known to increase the secretion of extracellular matrix from cardiac fibroblasts as well as the activation of paracrine signaling from cardiomyocytes, immune cells, and vascular cells, which rel
Externí odkaz:
https://doaj.org/article/81b9250985654c228d6e1e6220fcafad
Autor:
Samuel J. Geiseler, Alena Hadzic, Marvin Lambertus, Karl Martin Forbord, Ghazal Sajedi, Arthur Liesz, Cecilie Morland
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 2, p 1232 (2024)
Stroke is the main cause for acquired disabilities. Pharmaceutical or mechanical removal of the thrombus is the cornerstone of stroke treatment but can only be administered to a subset of patients and within a narrow time window. Novel treatment opti
Externí odkaz:
https://doaj.org/article/41699001ceec44d4a5ea9325561409f4
Publikováno v:
Antioxidants, Vol 12, Iss 12, p 2087 (2023)
Mitochondrial biogenesis and fusion are essential for maintaining healthy mitochondria and ATP production. High-intensity interval training (HIIT) can enhance mitochondrial function in mouse hippocampi, but its underlying mechanism is not completely
Externí odkaz:
https://doaj.org/article/cda16d1f2ff14de5998ea47b9e2afefd
Akademický článek
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Akademický článek
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Autor:
Mingyu Wang, Zequn Fan, Daiwen Chen, Bing Yu, Jun He, Jie Yu, Xiangbing Mao, Zhiqing Huang, Yuheng Luo, Junqiu Luo, Hui Yan, Ping Zheng
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 158, Iss , Pp 114148- (2023)
Colitis is a common and complex intestinal inflammatory disease in which lactate, a metabolite of anaerobic glycolysis, plays a crucial role. Our study aimed to investigate the alleviated effect of lactate in colitis, and to provide a nutritional mea
Externí odkaz:
https://doaj.org/article/c3cecb4d152446fe8125fa0fb8fd58f4
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Lactate and tumor cell-derived extracellular vesicles (TEVs) both contribute to tumor progression. However, it is still unclear whether lactate can accelerate tumor development by directly promoting TEV production. Here, we show that lactate decrease
Externí odkaz:
https://doaj.org/article/1fc43eee52b14b6297ec0b52caa759d3