Zobrazeno 1 - 10
of 1 141
pro vyhledávání: '"GPR55"'
Autor:
Jinlong Zhang, Jie Yan, Shuyue Li, Qianqian Chen, Jiang Lin, Yilin Peng, Yuhang Liu, Binbin Wang, Xinrong Wei, Chen Sun, Shuliang Niu
Publikováno v:
Heliyon, Vol 10, Iss 9, Pp e30462- (2024)
Methamphetamine is a potent and highly addictive neurotoxic psychostimulant that triggers a spectrum of adverse emotional responses during withdrawal. G-protein coupled receptor 55 (GPR55), a novel endocannabinoid receptor, is closely associated with
Externí odkaz:
https://doaj.org/article/00087b4a3b1b40fab24c5e044042f80e
Autor:
Antonia Manduca, Valeria Buzzelli, Alessandro Rava, Alessandro Feo, Emilia Carbone, Sara Schiavi, Barbara Peruzzi, Valentina D’Oria, Marco Pezzullo, Andrea Pasquadibisceglie, Fabio Polticelli, Vincenzo Micale, Martin Kuchar, Viviana Trezza
Publikováno v:
Pharmacological Research, Vol 203, Iss , Pp 107176- (2024)
Cannabidiol (CBD), a non-psychotomimetic constituent of Cannabis sativa, has been recently approved for epileptic syndromes often associated with Autism spectrum disorder (ASD). However, the putative efficacy and mechanism of action of CBD in patient
Externí odkaz:
https://doaj.org/article/3f98b6a7fe6c49cfbcacdf110dfacd47
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 13, p 7358 (2024)
GPR55 is a receptor for lysophosphatidylinositols (LPIs) in digestive metabolites. Overnutrition leads to obesity, insulin resistance, and increased LPI levels in the plasma. The involvement of LPIs and GPR55 in adiposity, hepatic steatosis, and athe
Externí odkaz:
https://doaj.org/article/68e964186f92439ba4cc834d653f6877
Autor:
Lu Sun, Matthias Apweiler, Claus Normann, Christoph W. Grathwol, Thomas Hurrle, Simone Gräßle, Nicole Jung, Stefan Bräse, Bernd L. Fiebich
Publikováno v:
Pharmaceuticals, Vol 17, Iss 6, p 674 (2024)
Chronic inflammation is driven by proinflammatory cytokines such as interleukin 6 (IL-6), tumor necrosis factor-α (TNF-α), and chemokines, such as c-c motif chemokine ligand 2 (CCL2), CCL3, C-X-C motif chemokine ligand 2 (CXCL2), and CXCL10. Inflam
Externí odkaz:
https://doaj.org/article/5dec51038a2b4687ba75c872588109e1
Autor:
Mikhail G. Akimov, Natalia M. Gretskaya, Polina V. Dudina, Galina D. Sherstyanykh, Galina N. Zinchenko, Oksana V. Serova, Ksenia O. Degtyaryova, Igor E. Deyev, Vladimir V. Bezuglov
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 6, p 5524 (2023)
GPR55 is a non-canonical cannabinoid receptor, important for cancer proliferation. Depending on the ligand, it induces either cell proliferation or death. The objective of the study was to establish the mechanisms of this multidirectional signaling.
Externí odkaz:
https://doaj.org/article/9d6728718ffa40d0b335f24f8962224d
Akademický článek
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Akademický článek
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Autor:
Michael Udoh, Chris Bladen, Marika Heblinski, Jia Lin Luo, Vaishali S. Janve, Lyndsey L. Anderson, Iain S. McGregor, Jonathon C. Arnold
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Introduction: Cannabidiol (CBD) has been clinically approved for intractable epilepsies, offering hope that novel anticonvulsants in the phytocannabinoid class might be developed. Looking beyond CBD, we have recently reported that a series of biosynt
Externí odkaz:
https://doaj.org/article/2ac18aa921254e2e99480afe336e1cce
Autor:
Baasanjav Uranbileg, Makoto Kurano, Kuniyuki Kano, Eri Sakai, Junichi Arita, Kiyoshi Hasegawa, Takeshi Nishikawa, Soichiro Ishihara, Hiroharu Yamashita, Yasuyuki Seto, Hitoshi Ikeda, Junken Aoki, Yutaka Yatomi
Publikováno v:
Clinical and Translational Medicine, Vol 12, Iss 9, Pp n/a-n/a (2022)
Abstract Background In addition to potent agonist properties for sphingosine 1‐phosphate (S1P) receptors, intracellularly, S1P is an intermediate in metabolic conversion pathway from sphingolipids to glycerolysophospholipids (glyceroLPLs). We hypot
Externí odkaz:
https://doaj.org/article/5cd81ea249b54027a2296d0bd8c846ea
Autor:
Roberto Chiocchetti, Giulia Salamanca, Margherita De Silva, Francesca Gobbo, Francesca Aspidi, Rodrigo Zamith Cunha, Giorgia Galiazzo, Claudio Tagliavia, Giuseppe Sarli, Maria Morini
Publikováno v:
Frontiers in Veterinary Science, Vol 9 (2022)
BackgroundAtopic dermatitis (AD) is one of the most common cutaneous inflammatory and pruritic diseases in dogs. Considering its multifactorial nature, AD can be a challenging disease to manage, and the therapeutic strategy must often be multimodal.
Externí odkaz:
https://doaj.org/article/80a0180b402a4359a25e3698108b6078