Zobrazeno 1 - 10
of 30
pro vyhledávání: '"GPR31"'
Akademický článek
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Autor:
Nicole Fehrenbacher, Mark R. Philips
Publikováno v:
Molecular & Cellular Oncology, Vol 4, Iss 6 (2017)
Effective anti-rat sarcoma viral oncogene (RAS) therapies have remained the holy grail of cancer treatment. Mutant Kirsten rat sarcoma viral oncogene homolog (KRAS) sustains tumorigenesis when linked to the plasma membrane (PM). The G protein-coupled
Externí odkaz:
https://doaj.org/article/e63e523585c14ce999cc34eef987222f
Autor:
Monica Napolitano
Publikováno v:
Biochemical Society Transactions. 47:743-754
The G protein-coupled receptors (GPCRs) constitute a large superfamily of seven transmembrane-spanning receptors that are activated by several classes of ligands, including bioactive lipids. GPCRs are attractive therapeutic targets for the treatment
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::197e6b5f5b94ab01c41af95370e617c5
https://doi.org/10.1042/bst20180635
https://doi.org/10.1042/bst20180635
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
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Publikováno v:
Biomedicines
Biomedicines, Vol 9, Iss 467, p 467 (2021)
Biomedicines, Vol 9, Iss 467, p 467 (2021)
Fatty acids (FAs) are considered not only as a basic nutrient, but are also recognized as signaling molecules acting on various types of receptors. The receptors activated by FAs include the family of rhodopsin-like receptors: GPR40 (FFAR1), GPR41 (F
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd0394398d760647de7c214e6ea53c84
https://pubmed.ncbi.nlm.nih.gov/33923318
https://pubmed.ncbi.nlm.nih.gov/33923318
Autor:
Lidija Covic, Elizabeth K. Fletcher, Nga Nguyen, Christopher Garzia, Layla Van Doren, Athan Kuliopulos, Ryan Stevenson, David Jaramillo
Publikováno v:
Arterioscler Thromb Vasc Biol
Objective: 12-LOX (12-lipoxygenase) produces a number of bioactive lipids including 12(S)-HETE that are involved in inflammation and platelet reactivity. The GPR31 (G-protein–coupled receptor 31) is the proposed receptor of 12(S)-HETE; however, it
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cebf75341ca44e408ea3b8447bc2e280
https://doi.org/10.1161/atvbaha.120.315154
https://doi.org/10.1161/atvbaha.120.315154
Autor:
Sarah A. Tersey, Isra Haider, Raghavendra G. Mirmira, Ryan M. Anderson, Marimar Hernandez-Perez
Publikováno v:
Diabetes. 69
Islet β-cell inflammation, dysfunction, and death are characteristic of diabetes. 12/15-Lipoxygenase (12/15-LOX) produces 12-HETE and is found activated under conditions of insulin resistance and systemic inflammation. 12-HETE acts as an inflammator
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ebbe8594e0b47acbd0e065c9600d5546
https://doi.org/10.2337/db20-2111-p
https://doi.org/10.2337/db20-2111-p
Autor:
Hisako Kayama, Junichi Kikuta, Naoki Morita, Junken Aoki, Asuka Inoue, Takeshi Haneda, Kiyoshi Takeda, Masaru Ishii, Ikuo Kimura, Ryu Okumura, Ryusuke Nabeshima, setsuko fujita, Akio Hayashi, Yuichi Maeda, Nobuhiko Okada, Hitomi Mimuro, Toshiyuki Kida, Toshio Imai, Eiji Umemoto
Publikováno v:
Nature. 566:110-114
Small intestinal mononuclear cells that express CX3CR1 (CX3CR1+ cells) regulate immune responses1-5. CX3CR1+ cells take up luminal antigens by protruding their dendrites into the lumen1-4,6. However, it remains unclear how dendrite protrusion by CX3C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::09bca5aa293a6145fd3e6eb6c000d0b1
https://doi.org/10.1038/s41586-019-0884-1
https://doi.org/10.1038/s41586-019-0884-1
Autor:
Kwang Jin Cho, Jie Shi, Craig Ramirez, Israel Tojal da Silva, Susan Thomas, Shafi Kuchay, Dafna Bar-Sagi, Nicole Fehrenbacher, John F. Hancock, Mark R. Philips, Yong Zhou, Michele Pagano
Publikováno v:
The Journal of Cell Biology
Mutant KRAS drives oncogenesis when associated with the plasma membrane. Fehrenbacher et al. identify GPR31, a G protein–coupled receptor, as a secretory pathway chaperone that guides the KRAS protein to the plasma membrane.
The product of the
The product of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3360a85c3e0803c6c44567e4467b1738
https://doi.org/10.1083/jcb.201609096
https://doi.org/10.1083/jcb.201609096
Autor:
Marimar Hernandez-Perez, Kimberly El, Ganesha Rai, Sarah A. Tersey, Cody A. Sorrell, Raghavendra G. Mirmira, Ansari Mukhtar Aleem, Abhishek Kulkarni, Theodore R. Holman, Isra Haider, Ryan M. Anderson, Niharika Samala
Publikováno v:
FASEB J
12-Lipoxygenase (12-LOX) is a key enzyme in arachidonic acid metabolism, and alongside its major product, 12-HETE, plays a key role in promoting inflammatory signaling during diabetes pathogenesis. Although 12-LOX is a proposed therapeutic target to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c85f1d6df1a7a680e0a86a62eaab75f
https://pubmed.ncbi.nlm.nih.gov/32918516
https://pubmed.ncbi.nlm.nih.gov/32918516