GPR137 inactivates Hippo signaling to promote gastric cancer cell malignancy

Autor: Lin Li, Jinlong Tang, Bin Cao, Qiang Xu, Shouying Xu, Chao Lin, Chao Tang

Publikováno v: Biology Direct, Vol 19, Iss 1, Pp 1-16 (2024)

Abstract As the fifth most common cancer in the world, gastric cancer (GC) ranks as the third major cause of cancer-related death globally. Although surgical resection and chemotherapy still remains the mainstay of potentially curative treatment for

Externí odkaz: https://doaj.org/article/4f95a178d86142049071344c4696681a

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The ESRP1-GPR137 axis contributes to intestinal pathogenesis

Autor: Lukas Franz Mager, Viktor Hendrik Koelzer, Regula Stuber, Lester Thoo, Irene Keller, Ivonne Koeck, Maya Langenegger, Cedric Simillion, Simona P Pfister, Martin Faderl, Vera Genitsch, Irina Tcymbarevich, Pascal Juillerat, Xiaohong Li, Yu Xia, Eva Karamitopoulou, Ruth Lyck, Inti Zlobec, Siegfried Hapfelmeier, Rémy Bruggmann, Kathy D McCoy, Andrew J Macpherson, Christoph Müller, Bruce Beutler, Philippe Krebs

Publikováno v: eLife, Vol 6 (2017)

Aberrant alternative pre-mRNA splicing (AS) events have been associated with several disorders. However, it is unclear whether deregulated AS directly contributes to disease. Here, we reveal a critical role of the AS regulator epithelial splicing reg

Externí odkaz: https://doaj.org/article/46127925fa504c6795248c15aa1ffdf6

Putative Receptors Underpinning l-Lactate Signalling in Locus Coeruleus

Autor: Sergey Kasparov, Kasumi Kishi, Matt De Both, Matthew J. Huentelman, Anja G. Teschemacher, Valentina Mosienko, Ali Rasooli-Nejad, David E. Jane

Publikováno v: Neuroglia
Volume 1
Issue 2
Pages 25-380
Mosienko, V, Rasooli-Nejad, A, Kishi, K, De Both, M, Jane, D, Huentelman, M, Kasparov, S & Teschemacher, A 2018, ' Putative Receptors Underpinning L-Lactate Signalling in Locus Coeruleus ', Neuroglia, vol. 1, no. 2, pp. 365-380 . https://doi.org/10.3390/neuroglia1020025

The importance of astrocytic l-lactate (LL) for normal functioning of neural circuits such as those regulating learning/memory, sleep/wake state, autonomic homeostasis, or emotional behaviour is being increasingly recognised. l-Lactate can act on neu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd403aba9aa1e85b25f99cb397fb6a1f
https://doi.org/10.3390/neuroglia1020025