The synthesis of cis- and trans-3-(4-hydroxyphenyl)cyclobutanecarboxylic acids and the study of their derivatives as GPR-40 receptor ligands

Autor: I. O. Feskov, I. S. Kondratov, Yu. O. Kuchkovska, V. S. Naumchyk, O. V. Onopchenko, O. O. Grygorenko

Publikováno v: Журнал органічної та фармацевтичної хімії, Vol 18, Iss 4(72), Pp 14-22 (2020)

Aim. To synthesize cis- and trans-isomers of 3-(4-hydroxyphenyl)cyclobutanecarboxylic acid and evaluate the biological activity of their derivatives against GPR-40. Results and discussion. Cis- and trans-isomers of 3-(4-hydroxyphenyl)cyclobutanecarbo

Externí odkaz: https://doaj.org/article/22033b8d36344219921bc75ce5849581

The synthesis of cis- and trans-3-(4-hydroxyphenyl)cyclobutanecarboxylic acids and the study of their derivatives as GPR-40 receptor ligands

Autor: Feskov, I. O., Kondratov, I. S., Kuchkovska, Yu. O., Naumchyk, V. S., Onopchenko, O. V., Grygorenko, O. O.

Publikováno v: Журнал органічної та фармацевтичної хімії; Том 18, № 4(72) (2020); 14-22
Journal of Organic and Pharmaceutical Chemistry; Том 18, № 4(72) (2020); 14-22
Журнал органической и фармацевтической химии; Том 18, № 4(72) (2020); 14-22

Aim. To synthesize cis- and trans-isomers of 3-(4-hydroxyphenyl)cyclobutanecarboxylic acid and evaluate the biological activity of their derivatives against GPR-40.Results and discussion. Cis- and trans-isomers of 3-(4-hydroxyphenyl)cyclobutanecarbox

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=scientific_p::8949f21f20cd29ab0e3ebcd5bd880d16
http://ophcj.nuph.edu.ua/article/view/ophcj.20.210383

Participação do GPR40 na ativação da NADPH oxidase na linhagem celular BRIN-BD11.

Autor: Librais, Gabriela Nunes Marsiglio

Linhagens secretoras de insulina, como a BRIN-BD11, são utilizadas para o estudo do mecanismo de secreção de insulina estimulado pela glicose (GSIS). Essas células expressam o GPR40, que quando ativado por ácidos graxos (AG), potencializam a GSI

Externí odkaz: http://www.teses.usp.br/teses/disponiveis/42/42137/tde-18112014-131712/