Zobrazeno 1 - 10
of 4 280
pro vyhledávání: '"GPCRs"'
Autor:
Liangjing Lv, Yong Liu, Jiachuan Xiong, Shaobo Wang, Yan Li, Bo Zhang, Yinghui Huang, Jinghong Zhao
Publikováno v:
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-18 (2024)
Abstract Acute kidney injury (AKI) is a clinical condition characterized by a rapid decline in kidney function, which is associated with local inflammation and programmed cell death in the kidney. The G protein-coupled receptors (GPCRs) represent the
Externí odkaz:
https://doaj.org/article/97ada73864354f809fdd524c0254de87
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract Melatonin is a multifunctional molecule with diverse biological roles that holds great value as a health-promoting bioactive molecule in any food product and yeast’s ability to produce it has been extensively demonstrated in the last decad
Externí odkaz:
https://doaj.org/article/8e2dbcf18ae74bd5acb1a10d6c243800
Autor:
Chengyan Wu, Li Hu, Bing Liu, Xingyue Zeng, Haixiang Ma, Yongkai Cao, Huijun Li, Xiaohan Zhang
Publikováno v:
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-21 (2024)
Abstract Background Desensitization of G protein–coupled receptors (GPCRs) refers to the attenuation of receptor responsiveness by prolonged or intermittent exposure to agonists. The binding of β-arrestin to the cytoplasmic cavity of the phosphory
Externí odkaz:
https://doaj.org/article/f3701ddc2a404145a996f3425169d540
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Neurodegenerative disorders represent a significant and growing health burden worldwide. Unfortunately, limited therapeutic options are currently available despite ongoing efforts. Over the past decades, research efforts have increasingly focused on
Externí odkaz:
https://doaj.org/article/dffc5190cdf24f4f8568811e79960bf2
Publikováno v:
eLife, Vol 12 (2024)
Phosphoinositide 3-kinase (PI3K) beta (PI3Kβ) is functionally unique in the ability to integrate signals derived from receptor tyrosine kinases (RTKs), G-protein coupled receptors, and Rho-family GTPases. The mechanism by which PI3Kβ prioritizes in
Externí odkaz:
https://doaj.org/article/6de0b5fba85a44e4a804a1cf78fa3cea
Autor:
Natalia V. Ortiz Zacarías, Sascha Röth, Jeremy D. Broekhuis, Daan van der Es, Kevin Moreau, Laura H. Heitman
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 16, p 8984 (2024)
CC chemokine receptor 2 (CCR2) has been linked to many inflammatory and immune diseases, making it a relevant drug target. Yet, all CCR2 antagonists developed so far have failed in clinical trials; thus, novel strategies are needed to target this rec
Externí odkaz:
https://doaj.org/article/6db528a29d49459988b2161f531381fd
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 15, p 8083 (2024)
Cancer cells depend on specific oncogenic pathways or present a genetic alteration that leads to a particular disturbance. Still, personalized and targeted biological therapy remains challenging, with current efforts generally yielding disappointing
Externí odkaz:
https://doaj.org/article/41a198f733d84bc1bc6958313d0455d3
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 12 (2024)
Extracellular acidification of tumors is common. Through proton-sensing ion channels or proton-sensing G protein-coupled receptors (GPCRs), tumor cells sense extracellular acidification to stimulate a variety of intracellular signaling pathways inclu
Externí odkaz:
https://doaj.org/article/1f494830897449f5a6f16e8f58997d9a
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 172, Iss , Pp 116245- (2024)
‘Globesity’ is a foremost challenge to the healthcare system. The limited efficacy and adverse effects of available oral pharmacotherapies pose a significant obstacle in the fight against obesity. The biology of the leading incretin hormone gluca
Externí odkaz:
https://doaj.org/article/6874e76769684b69833793033db890ff