Zobrazeno 1 - 10
of 4 247
pro vyhledávání: '"GPCRs"'
Autor:
Moragot Chatatikun, Nawanwat C. Pattaranggoon, Imran Sama-ae, Onggan Ranteh, Manlika Poolpirom, Oranan Pantanakong, Pitchaporn Chumworadet, Fumitaka Kawakami, Motoki Imai, Aman Tedasen
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-16 (2024)
Abstract G Protein-Coupled Receptors (GPCRs) are integral membrane proteins that have gained considerable attention as drug targets, particularly in cancer treatment. In this study, we explored the capacity of bioactive compounds derived from Gnetum
Externí odkaz:
https://doaj.org/article/64a51f6c99b24ae98952e68ffbf0a473
Autor:
Jinuk Kim, Chulwon Choi
Publikováno v:
Current Issues in Molecular Biology, Vol 46, Iss 10, Pp 11646-11664 (2024)
Neurodegenerative disorders, particularly Alzheimer’s and Parkinson’s diseases, continue to challenge modern medicine despite therapeutic advances. Orphan G-protein-coupled receptors (GPCRs) have emerged as promising targets in the central nervou
Externí odkaz:
https://doaj.org/article/594ecc28e93d4a6b8b45bb753d696dc2
Autor:
Kienleitner Filip, Lenk Kerstin
Publikováno v:
Current Directions in Biomedical Engineering, Vol 10, Iss 3, Pp 5-8 (2024)
In addition to neurons, glial cells make up the nervous system. These glial cells are divided into macroglial cells - including astrocytes - and microglial cells. Astrocytes have several important functions in the central nervous system, such as synt
Externí odkaz:
https://doaj.org/article/6c990830360745cf90d2013829310664
Autor:
Xinyan Li, Chao Li, Yang Kang, Rui Zhang, Peiyao Li, Qian Zheng, Hui Wang, Hui Xiao, Lei Yuan
Publikováno v:
FASEB BioAdvances, Vol 6, Iss 9, Pp 289-297 (2024)
Abstract Apoptosis is a genetically programmed form of cell death that is substantially conserved across the evolutionary tree. Apoptotic cell elimination includes recognition, phagocytosis, and degradation. Failure to clear apoptotic cells can ultim
Externí odkaz:
https://doaj.org/article/ba1f902bbf0946eaaf81b7075c03ce0e
Autor:
Liangjing Lv, Yong Liu, Jiachuan Xiong, Shaobo Wang, Yan Li, Bo Zhang, Yinghui Huang, Jinghong Zhao
Publikováno v:
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-18 (2024)
Abstract Acute kidney injury (AKI) is a clinical condition characterized by a rapid decline in kidney function, which is associated with local inflammation and programmed cell death in the kidney. The G protein-coupled receptors (GPCRs) represent the
Externí odkaz:
https://doaj.org/article/97ada73864354f809fdd524c0254de87
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract Melatonin is a multifunctional molecule with diverse biological roles that holds great value as a health-promoting bioactive molecule in any food product and yeast’s ability to produce it has been extensively demonstrated in the last decad
Externí odkaz:
https://doaj.org/article/8e2dbcf18ae74bd5acb1a10d6c243800
Autor:
Shamin Li, Fabien Melchiore, Chahrazade Kantari-Mimoun, Aurore Mouton, Samantha Knockaert, Wendy Philippon, Benjamin Chanrion, Christophe Bourgeois, Céline Lefebvre, Jamila Elhmouzi-Younes, Véronique Blanc, Fernando Ramon Olayo, Bruno Laugel
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
The success of cancer immunotherapies such as immune checkpoint inhibitors, CAR T-cells and immune cell engagers have provided clinicians with tools to bypass some of the limitations of cancer immunity. However, numerous tumour factors curtail the im
Externí odkaz:
https://doaj.org/article/f077140e624c4dffa6743541f972e6ea
Autor:
Chengyan Wu, Li Hu, Bing Liu, Xingyue Zeng, Haixiang Ma, Yongkai Cao, Huijun Li, Xiaohan Zhang
Publikováno v:
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-21 (2024)
Abstract Background Desensitization of G protein–coupled receptors (GPCRs) refers to the attenuation of receptor responsiveness by prolonged or intermittent exposure to agonists. The binding of β-arrestin to the cytoplasmic cavity of the phosphory
Externí odkaz:
https://doaj.org/article/f3701ddc2a404145a996f3425169d540
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Neurodegenerative disorders represent a significant and growing health burden worldwide. Unfortunately, limited therapeutic options are currently available despite ongoing efforts. Over the past decades, research efforts have increasingly focused on
Externí odkaz:
https://doaj.org/article/dffc5190cdf24f4f8568811e79960bf2
Publikováno v:
eLife, Vol 12 (2024)
Phosphoinositide 3-kinase (PI3K) beta (PI3Kβ) is functionally unique in the ability to integrate signals derived from receptor tyrosine kinases (RTKs), G-protein coupled receptors, and Rho-family GTPases. The mechanism by which PI3Kβ prioritizes in
Externí odkaz:
https://doaj.org/article/6de0b5fba85a44e4a804a1cf78fa3cea