Zobrazeno 1 - 10
of 21 510
pro vyhledávání: '"GPCR"'
Autor:
Saskia Borsdorf, Andre Zeug, Yuxin Wu, Elena Mitroshina, Maria Vedunova, Supriya A. Gaitonde, Michel Bouvier, Michael C. Wehr, Josephine Labus, Evgeni Ponimaskin
Publikováno v:
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-18 (2024)
Abstract Background Homo- and heteromerization of G protein-coupled receptors (GPCRs) plays an important role in the regulation of receptor functions. Recently, we demonstrated an interaction between the serotonin receptor 7 (5-HT7R), a class A GPCR,
Externí odkaz:
https://doaj.org/article/d315acceb0f14b93bf9378975e6ec331
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)
Abstract Conserved protein-coding sequences are critical for maintaining protein function across species. Odorant receptors (ORs), a large poorly understood multigene family responsible for odor detection, lack comprehensive classification methods th
Externí odkaz:
https://doaj.org/article/4b84769f5398451bae37d6485fd6928c
Publikováno v:
Cellular & Molecular Biology Letters, Vol 29, Iss 1, Pp 1-23 (2024)
Abstract Transactivation of epidermal growth factor receptors (EGFR) provides intricate control over multiple regulatory cellular processes that merge the diversity of G protein-coupled receptors (GPCRs) with the robust signaling capacities of recept
Externí odkaz:
https://doaj.org/article/c809f781c35341f786a27114164239b3
Autor:
Hanting Yang, Yongfu Wang, Wei Liu, Taiping He, Jiayu Liao, Zhongzhi Qian, Jinghao Zhao, Zhaotong Cong, Dan Sun, Zhixiang Liu, Can Wang, Lingping Zhu, Shilin Chen
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 14, Iss 10, Pp 4296-4311 (2024)
G protein-coupled receptors (GPCRs) are pivotal in mediating diverse physiological and pathological processes, rendering them promising targets for drug discovery. GPCRs account for about 40% of FDA-approved drugs, representing the most successful dr
Externí odkaz:
https://doaj.org/article/e860f0f034d94446ae35e2edb5bdc19c
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 43, Iss 1, Pp 1-8 (2024)
Abstract Recent progress in elucidating the role of specific antidiuretic hormones in Drosophila models has provided valuable insights into the mechanisms underlying tumor-induced renal dysfunction. Xu et al. identified the mammalian neurokinin 3 rec
Externí odkaz:
https://doaj.org/article/352e674ac53c49558b1c3c5fa42fa2a0
Autor:
Luca Golinelli, Ellen Geens, Allister Irvine, Ciaran J. McCoy, Elke Vandewyer, Louise E. Atkinson, Angela Mousley, Liesbet Temmerman, Isabel Beets
Publikováno v:
BMC Biology, Vol 22, Iss 1, Pp 1-21 (2024)
Abstract Background The phylum Nematoda is incredibly diverse and includes many parasites of humans, livestock, and plants. Peptide-activated G protein-coupled receptors (GPCRs) are central to the regulation of physiology and numerous behaviors, and
Externí odkaz:
https://doaj.org/article/c2d670455c1b439c9fcacc8998ab993e
Autor:
Sazanami Mori, Natsuki Nakamura, Ayane Fuchigami, Satoshi Yoshimoto, Moe Sakakibara, Toshiyuki Ozawa, Junken Aoki, Asuka Inoue, Hayakazu Sumida, Hideya Ando, Motonao Nakamura
Publikováno v:
FASEB BioAdvances, Vol 6, Iss 10, Pp 424-441 (2024)
Abstract Bitter taste receptors (TAS2Rs) are not only expressed in the oral cavity but also in skin. Extraoral TAS2Rs are thought to be involved in non‐taste perception and tissue‐specific functions. Keratinocytes that express TAS2Rs in the skin
Externí odkaz:
https://doaj.org/article/87f2088083af4c1389595ee070e7630c
Osteocalcin binds to a GPRC6A Venus fly trap allosteric site to positively modulate GPRC6A signaling
Publikováno v:
FASEB BioAdvances, Vol 6, Iss 9, Pp 365-376 (2024)
Abstract GPRC6A, a member of the Family C G‐protein coupled receptors, regulates energy metabolism and sex hormone production and is activated by diverse ligands, including cations, L‐amino acids, the osteocalcin (Ocn) peptide and the steroid hor
Externí odkaz:
https://doaj.org/article/6595614307174a96a72a2183c31401dd
Autor:
Liangjing Lv, Yong Liu, Jiachuan Xiong, Shaobo Wang, Yan Li, Bo Zhang, Yinghui Huang, Jinghong Zhao
Publikováno v:
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-18 (2024)
Abstract Acute kidney injury (AKI) is a clinical condition characterized by a rapid decline in kidney function, which is associated with local inflammation and programmed cell death in the kidney. The G protein-coupled receptors (GPCRs) represent the
Externí odkaz:
https://doaj.org/article/97ada73864354f809fdd524c0254de87
Autor:
Min Jae Seo, Wookyung Yu
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 23, Iss , Pp 3445-3453 (2024)
G protein-coupled receptor kinases (GRKs) are essential regulators of signaling pathways mediated by G protein-coupled receptors. Recent research suggests that GRK-mediated phosphorylation patterns dictate functional selectivity, leading to biased ce
Externí odkaz:
https://doaj.org/article/fc0988a11f2d4539b886fd9d64aaa9e7