Zobrazeno 1 - 10
of 222
pro vyhledávání: '"GP Bates"'
Autor:
Mayte Suárez-Fariñas, Liliana B. Menalled, Christina Leahy, Larry Park, Allan J. Tobin, Ethan Signer, Vanessa C. Wheeler, Monica Patry, Daniela Brunner, Marcy E. MacDonald, Janet M. Leeds, A. Jennifer Morton, X. William Yang, David Howland, Bassem F. El-Khodor, GP Bates, Benjamin Zahasky, Samantha J. Orenstein
Publikováno v:
Neurobiology of Disease, Vol 35, Iss 3, Pp 319-336 (2009)
Huntington's disease (HD) is one of the few neurodegenerative diseases with a known genetic cause, knowledge that has enabled the creation of animal models using genetic manipulations that aim to recapitulate HD pathology. The study of behavioral and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::557ce41620d6b4eb0ad112bf58a91534
https://doi.org/10.1016/j.nbd.2009.05.007
https://doi.org/10.1016/j.nbd.2009.05.007
Autor:
GP Bates
Publikováno v:
Journal of Neurology, Neurosurgery & Psychiatry. 85:A6-A7
Progressive pathophysiological changes have been identified in multiple peripheral tissue and organs in a wide range of mouse models of Huntington’s disease (HD). Well studied examples include skeletal muscle, the pancreas, the heart, the hypothala
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7a14742e0037090e45d4d85a6008bbbc
https://doi.org/10.1136/jnnp-2014-309032.19
https://doi.org/10.1136/jnnp-2014-309032.19
Publikováno v:
Journal of Neurology, Neurosurgery & Psychiatry. 85:A25-A25
Background The R6/2 mouse model of Huntington’s disease (HD) is one of the most widely used models in HD research and contains human exon1 of HTT with a CAG/polyglutamine (polyQ) repeat expansion. When created the R6/2 line had a repeat expansion o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1c3a9eb6ba616457bfe488c095d55eee
https://doi.org/10.1136/jnnp-2014-309032.74
https://doi.org/10.1136/jnnp-2014-309032.74
Autor:
D Goodwin, G Salsbury, NS Ali, Ignacio Munoz-Sanjuan, Sophie A. Franklin, Larry Park, Georg Bernhard Landwehrmeyer, GP Bates, Georgina F. Osborne
Publikováno v:
Journal of Neurology, Neurosurgery & Psychiatry. 85:A35-A35
Background The ability to monitor clinical trials in Huntington’s disease (HD) patients with pharmacodynamic read outs will be essential, and PET ligands that give altered signals in HD patient brains are being considered for use in monitoring hunt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4160d1f28df47cbc89973e11c032ea9b
https://doi.org/10.1136/jnnp-2014-309032.103
https://doi.org/10.1136/jnnp-2014-309032.103
Autor:
GP Bates, Christian Landles, Sophie A. Franklin, Donna L. Smith, G Salsbury, Hayley Lazell, D Goodwin, Agnesska C. Benjamin, NS Ali, Georgina F. Osborne
Publikováno v:
Journal of Neurology, Neurosurgery & Psychiatry. 85:A25-A25
Background The zQ175 knock-in line was generated by replacing mouse endogenous Htt exon 1 with a mutant version of human HTT exon 1 followed by the expansion of the CAG repeat. This line is now being used extensively throughout the HD research commun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dcded68cfc5b7e2fc318f4987169c060
https://doi.org/10.1136/jnnp-2014-309032.75
https://doi.org/10.1136/jnnp-2014-309032.75
Autor:
Hayley Lazell, Tobias C. Wood, Ignacio Munoz-Sanjuan, Se-Jin Lee, Agnesska C. Benjamin, Linda Greensmith, David Howland, D Goodwin, A Lehar, X Chang, Mhoriam Ahmed, Ivan Rattray, Marie K. Bondulich, Georgina F. Osborne, Jrt Dick, Sophie A. Franklin, Nelly Jolinon, GP Bates, Michal Mielcarek, Donna L. Smith
Publikováno v:
Journal of Neurology, Neurosurgery & Psychiatry. 85:A97-A97
Muscle atrophy is a well-documented symptom of Huntington’s disease (HD) and there are multiple lines of evidence to support a muscle-based pathology in HD patients and in mouse models of HD. Inhibition of the myostatin signalling pathway has been
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fb949819b6109e97f5ace599695a6c2b
https://doi.org/10.1136/jnnp-2014-309032.281
https://doi.org/10.1136/jnnp-2014-309032.281
Autor:
GP Bates, Andreas Neueder
Publikováno v:
Journal of Neurology, Neurosurgery & Psychiatry. 85:A34-A34
Background Huntington’s disease (HD) belongs to the group of poly-glutamine repeat expansion diseases, which is the most common form of inherited neurodegenerative diseases. Transcriptional dysregulation, or a global change in gene expression is a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f830afb4da865abf7dec6a8517948bc6
https://doi.org/10.1136/jnnp-2014-309032.100
https://doi.org/10.1136/jnnp-2014-309032.100
Autor:
Jose Beltran, Dansha He, Kimmo Lehtimäki, Steve Oakeshott, Neil G. Paterson, Igor Filippov, Michael H. Olsen, Justin Torello, Dani Brunner, David Howland, Douglas Macdonald, Andrea E. Kudwa, Kimberly Cox, Kristi McConnell, Georgina F. Osborne, Samuel I. Miller, Mei Kwan, GP Bates, Jon Fitzpatrick, Pasi Tuunanen, Andrew M. Farrar, Sylvie Ramboz, Rand Al-Nackkash, Afshin Ghavami, Ignacio Munoz-Sanjuan, Larry Park, Richard Mushlin, Matthew J. Mazzella, Liliana B. Menalled
Publikováno v:
PLoS ONE
PLoS ONE, Vol 9, Iss 6, p e99520 (2014)
PLoS ONE, Vol 9, Iss 6, p e99520 (2014)
Huntington's disease (HD) is an autosomal dominant, progressive neurodegenerative disorder caused by expansion of CAG repeats in the huntingtin gene. Tissue transglutaminase 2 (TG2), a multi-functional enzyme, was found to be increased both in HD pat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7763aed1a0c46cfda4c3d28ea32040ae
https://doi.org/10.1371/journal.pone.0099520
https://doi.org/10.1371/journal.pone.0099520
Autor:
Ulrike Träger, Andre R, Magnusson-Lind A, Jr, Miller, Connolly C, Weiss A, Grueninger S, Silajdžić E, Dl, Smith, Br, Leavitt, Gp, Bates, Björkqvist M, Sj, Tabrizi
Publikováno v:
Europe PubMed Central
CIÊNCIAVITAE
CIÊNCIAVITAE
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::30141dce0c23b3245ebd7e79cfe9f137
http://europepmc.org/abstract/med/25447230
http://europepmc.org/abstract/med/25447230
Autor:
Pupak A; Departament de Biomedicina, Facultat de Medicina, Institut de Neurosciències, Universitat de Barcelona, Barcelona, Spain.; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain., Rodríguez-Navarro I; Departament de Biomedicina, Facultat de Medicina, Institut de Neurosciències, Universitat de Barcelona, Barcelona, Spain.; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain., Sathasivam K; Department of Neurodegenerative Disease, Huntington's Disease Centre and UK Dementia Research Institute at UCL, Queen Square Institute of Neurology, UCL, London, WC1N 3BG, UK., Singh A; Department for Molecular Biology and Genetics, Aarhus University, Aarhus C, Denmark.; Department of Biomedicine, Aarhus University, Aarhus C, Denmark., Essmann A; Departament de Biomedicina, Facultat de Medicina, Institut de Neurosciències, Universitat de Barcelona, Barcelona, Spain.; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain., Del Toro D; Departament de Biomedicina, Facultat de Medicina, Institut de Neurosciències, Universitat de Barcelona, Barcelona, Spain.; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain., Ginés S; Departament de Biomedicina, Facultat de Medicina, Institut de Neurosciències, Universitat de Barcelona, Barcelona, Spain.; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain., Mouro Pinto R; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Department of Neurology, Harvard Medical School, Boston, MA, USA.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Bates GP; Department of Neurodegenerative Disease, Huntington's Disease Centre and UK Dementia Research Institute at UCL, Queen Square Institute of Neurology, UCL, London, WC1N 3BG, UK., Vang Ørom UA; Department for Molecular Biology and Genetics, Aarhus University, Aarhus C, Denmark., Martí E; Departament de Biomedicina, Facultat de Medicina, Institut de Neurosciències, Universitat de Barcelona, Barcelona, Spain.; Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain., Brito V; Departament de Biomedicina, Facultat de Medicina, Institut de Neurosciències, Universitat de Barcelona, Barcelona, Spain. veronica.brito@ub.edu.; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain. veronica.brito@ub.edu.; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain. veronica.brito@ub.edu.
Publikováno v:
EMBO reports [EMBO Rep] 2024 Oct 11. Date of Electronic Publication: 2024 Oct 11.