Zobrazeno 1 - 10
of 17 376
pro vyhledávání: '"GORDON B"'
Autor:
Jennifer M. Finan, Roberto Di Niro, Soon Young Park, Kang Jin Jeong, Madeline D. Hedberg, Alexander Smith, Grace A. McCarthy, Alex O. Haber, John Muschler, Rosalie C. Sears, Gordon B. Mills, William H. Gmeiner, Jonathan R. Brody
Publikováno v:
Cancer Biology & Therapy, Vol 25, Iss 1 (2024)
Pancreatic ductal adenocarcinoma (PDAC) is a lethal disease soon to become the second leading cause of cancer deaths in the US. Beside surgery, current therapies have narrow clinical benefits with systemic toxicities. FOLFIRINOX is the current standa
Externí odkaz:
https://doaj.org/article/31179cb813084425aaab19da48c81dcf
Autor:
Sarina A. Piha-Paul, Chieh Tseng, Cheuk Hong Leung, Ying Yuan, Daniel D. Karp, Vivek Subbiah, David Hong, Siqing Fu, Aung Naing, Jordi Rodon, Milind Javle, Jaffer A. Ajani, Kanwal P. Raghav, Neeta Somaiah, Gordon B. Mills, Apostolia M. Tsimberidou, Xiaofeng Zheng, Ken Chen, Funda Meric-Bernstam
Publikováno v:
npj Precision Oncology, Vol 8, Iss 1, Pp 1-14 (2024)
Abstract Cancer cells with BRCA1/2 deficiencies are sensitive to poly (ADP-ribose) polymerase (PARP) inhibitors. We evaluated the efficacy of talazoparib in DNA-Damage Repair (DDR)-altered patients. In this phase II trial, patients were enrolled onto
Externí odkaz:
https://doaj.org/article/1e0d0ae9bd434d9dbecfece7f428357b
Autor:
Xi Li, Alfonso Poire, Kang Jin Jeong, Dong Zhang, Tugba Yildiran Ozmen, Gang Chen, Chaoyang Sun, Gordon B. Mills
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract Although Poly (ADP-ribose) polymerase (PARP) inhibitors (PARPi) have been approved in multiple diseases, including BRCA1/2 mutant breast cancer, responses are usually transient requiring the deployment of combination therapies for optimal ef
Externí odkaz:
https://doaj.org/article/87332cc7bc164961bc45782eb7c90b2e
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract During development, cortical activity is organized into distributed modular patterns that are a precursor of the mature columnar functional architecture. Theoretically, such structured neural activity can emerge dynamically from local synapt
Externí odkaz:
https://doaj.org/article/4ca0c42bceaf4c068d50fcac7cae1103
Autor:
Gordon B. Bonan, Oliver Lucier, Deborah R. Coen, Adrianna C. Foster, Jacquelyn K. Shuman, Marysa M. Laguë, Abigail L. S. Swann, Danica L. Lombardozzi, William R. Wieder, Kyla M. Dahlin, Adrian V. Rocha, Michael D. SanClements
Publikováno v:
Journal of Advances in Modeling Earth Systems, Vol 16, Iss 8, Pp n/a-n/a (2024)
Abstract Terrestrial, aquatic, and marine ecosystems regulate climate at local to global scales through exchanges of energy and matter with the atmosphere and assist with climate change mitigation through nature‐based climate solutions. Climate sci
Externí odkaz:
https://doaj.org/article/61f6153125834e71a5055adbcbf19050
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-6 (2024)
Abstract Cyclic Immunofluorescence (CyCIF) can quantify multiple biomarkers, but panel capacity is limited by technical challenges. We propose a computational panel reduction approach that can impute the information content from 25 markers using only
Externí odkaz:
https://doaj.org/article/ad03cbe49d734938a2d088691bb306da
Autor:
Marco N. Allemann, Marissa Tessman, Jaysen Reindel, Gordon B. Scofield, Payton Evans, Robert S. Pomeroy, Michael D. Burkart, Stephen P. Mayfield, Ryan Simkovsky
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-10 (2024)
Abstract The accumulation of microplastics in various ecosystems has now been well documented and recent evidence suggests detrimental effects on various biological processes due to this pollution. Accumulation of microplastics in the natural environ
Externí odkaz:
https://doaj.org/article/9e8465f30a4e49718b892f75f0882e46
Autor:
Simon Kern, Juliane Nagel, Martin F Gerchen, Çağatay Gürsoy, Andreas Meyer-Lindenberg, Peter Kirsch, Raymond J Dolan, Steffen Gais, Gordon B Feld
Publikováno v:
eLife, Vol 12 (2024)
Declarative memory retrieval is thought to involve reinstatement of neuronal activity patterns elicited and encoded during a prior learning episode. Furthermore, it is suggested that two mechanisms operate during reinstatement, dependent on task dema
Externí odkaz:
https://doaj.org/article/39aa55958a334ffa8a5cd25404005b17
Publikováno v:
Comparative Cognition & Behavior Reviews, Vol 19, Pp 9-13 (2024)
Externí odkaz:
https://doaj.org/article/5ce4a473e6424ec8b1adfa8b6b89defa
Autor:
Turcin Saridogan, Argun Akcakanat, Ming Zhao, Kurt W. Evans, Erkan Yuca, Stephen Scott, Bryce P. Kirby, Xiaofeng Zheng, Min Jin Ha, Huiqin Chen, Patrick K. S. Ng, Timothy P. DiPeri, Gordon B. Mills, Jordi Rodon Ahnert, Senthil Damodaran, Funda Meric-Bernstam
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-15 (2023)
Abstract Several alterations in fibroblast growth factor receptor (FGFR) genes have been found in breast cancer; however, they have not been well characterized as therapeutic targets. Futibatinib (TAS-120; Taiho) is a novel, selective, pan-FGFR inhib
Externí odkaz:
https://doaj.org/article/54d8ba5ed19745f68237d1d74ca99a08