Zobrazeno 1 - 10
of 146
pro vyhledávání: '"GONG-KAN FENG"'
Autor:
Wei Chen, Kai-Bin Yang, Yuan-Zhe Zhang, Zai-Shan Lin, Jin-Wei Chen, Si-Fan Qi, Chen-Fei Wu, Gong-Kan Feng, Da-Jun Yang, Ming Chen, Xiao-Feng Zhu, Xuan Li
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 43, Iss 1, Pp 1-20 (2024)
Abstract Background High expression of ubiquitin ligase MDM2 is a primary cause of p53 inactivation in many tumors, making it a promising therapeutic target. However, MDM2 inhibitors have failed in clinical trials due to p53-induced feedback that enh
Externí odkaz:
https://doaj.org/article/36aa2479810046219abd7234f4f5e8a9
Autor:
Kai‐Ming Zhang, De‐Chang Zhao, Ze‐Yu Li, Yan Wang, Jian‐Nan Liu, Tian Du, Ling Zhou, Yu‐Hong Chen, Qi‐Chao Yu, Qing‐Shan Chen, Rui‐Zhao Cai, Zi‐Xuan Zhao, Jia‐Lu Shan, Bing‐Xin Hu, Hai‐Liang Zhang, Gong‐Kan Feng, Xiao‐Feng Zhu, Jun Tang, Rong Deng
Publikováno v:
Advanced Science, Vol 11, Iss 35, Pp n/a-n/a (2024)
Abstract Endocrine‐resistant ER+HER2– breast cancer (BC) is particularly aggressive and leads to poor clinical outcomes. Effective therapeutic strategies against endocrine‐resistant BC remain elusive. Here, analysis of the RNA‐sequencing data
Externí odkaz:
https://doaj.org/article/0bb97eb8b1b84525bea91c117811fad7
Autor:
Dong Yang, Mei-Han Duan, Qiu-Er Yuan, Zhi-Ling Li, Chuang-Hua Luo, Lan-Yue Cui, Li-Chao Li, Ying Xiao, Xian-Ying Zhu, Hai-Liang Zhang, Gong-Kan Feng, Guo-Chen Liu, Rong Deng, Jun-Dong Li, Xiao-Feng Zhu
Publikováno v:
Journal of Translational Medicine, Vol 21, Iss 1, Pp 1-16 (2023)
Abstract Background As the most lethal gynecologic cancer, ovarian cancer (OV) holds the potential of being immunotherapy-responsive. However, only modest therapeutic effects have been achieved by immunotherapies such as immune checkpoint blockade. T
Externí odkaz:
https://doaj.org/article/737309b875aa4eac9816f33c5500285a
Autor:
Shan Liu, Hai-Liang Zhang, Jing Li, Zhi-Peng Ye, Tian Du, Li-Chao Li, Yi-Qing Guo, Dong Yang, Zhi-Ling Li, Jiang-Hua Cao, Bing-Xin Hu, Yu-Hong Chen, Gong-Kan Feng, Zhi-Ming Li, Rong Deng, Jia-Jia Huang, Xiao-Feng Zhu
Publikováno v:
Redox Biology, Vol 62, Iss , Pp 102677- (2023)
Ferroptosis, an iron-dependent lipid peroxidation-driven programmed cell death, is closely related to cancer therapy. The development of druggable ferroptosis inducers and their rational application in cancer therapy are critical. Here, we identified
Externí odkaz:
https://doaj.org/article/cc455e40662a47a2a8b83d1c0b4d5347
Autor:
Yan Yu, Xiao-Dan Peng, Xiao-Jun Qian, Kai-Ming Zhang, Xiang Huang, Yu-Hong Chen, Yun-Tian Li, Gong-Kan Feng, Hai-Liang Zhang, Xue-Lian Xu, Shun Li, Xuan Li, Jia Mai, Zhi-Ling Li, Yun Huang, Dong Yang, Li-Huan Zhou, Zhuo-Yan Zhong, Jun-Dong Li, Rong Deng, Xiao-Feng Zhu
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 6, Iss 1, Pp 1-15 (2021)
Abstract Met tyrosine kinase, a receptor for a hepatocyte growth factor (HGF), plays a critical role in tumor growth, metastasis, and drug resistance. Mitochondria are highly dynamic and undergo fission and fusion to maintain a functional mitochondri
Externí odkaz:
https://doaj.org/article/6601f6c66f7649e89ed624b91b63f812
Autor:
Yun Huang, Hai-Liang Zhang, Zhi-Ling Li, Tian Du, Yu-Hong Chen, Yan Wang, Huan-He Ni, Kai-Ming Zhang, Jia Mai, Bing-Xin Hu, Jun-Hao Huang, Li-Huan Zhou, Dong Yang, Xiao-Dan Peng, Gong-Kan Feng, Jun Tang, Xiao-Feng Zhu, Rong Deng
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
B7H3 is a transmembrane B7 family checkpoint molecule present on many cancer cells. Here the authors show that FUT8 mediates fucosylation of B7H3 to limit the immune response to triple-negative breast cancer as a potentially targeted mechanism of non
Externí odkaz:
https://doaj.org/article/1258b476d9c94dcb951013c2b2aa4bd4
Autor:
Rong Deng, Jun-Hao Huang, Yan Wang, Li-Huan Zhou, Zi-Feng Wang, Bing-Xin Hu, Yu-Hong Chen, Dong Yang, Jia Mai, Zhi-Ling Li, Hai-Liang Zhang, Yun Huang, Xiao-Dan Peng, Gong-Kan Feng, Xiao-Feng Zhu, Jun Tang
Publikováno v:
Molecular Cancer, Vol 19, Iss 1, Pp 1-19 (2020)
Abstract Background Super-enhancers (SEs) play a crucial role in cancer, which is often associate with activated oncogenes. However, little is known about how SEs facilitate tumour suppression. Individuals with Down syndrome exhibit a remarkably redu
Externí odkaz:
https://doaj.org/article/c783cc81ed904bdc9047df12929166f1
Autor:
Zhi-Ling Li, Hai-Liang Zhang, Yun Huang, Jun-Hao Huang, Peng Sun, Ning-Ning Zhou, Yu-Hong Chen, Jia Mai, Yan Wang, Yan Yu, Li-Huan Zhou, Xuan Li, Dong Yang, Xiao-Dan Peng, Gong-Kan Feng, Jun Tang, Xiao-Feng Zhu, Rong Deng
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-19 (2020)
T cell mediated therapies have proven largely unsuccessful in triple-negative breast cancer (TNBC). Here, the authors show that autophagy is reduced in TNBC, which results in an increase in Tenascin C and reduced activation of tumour infiltrating lym
Externí odkaz:
https://doaj.org/article/679056fb338f417b9f0c24912564acaa
Autor:
Dong Yang, Fu-Xue Huang, Wei Wei, Qia-Qia Li, Jun-Wan Wu, Yun Huang, Zhi-Ling Li, Hai-Liang Zhang, Xuan Li, Qiu-Er Yuan, Qing-shan Chen, Gong-kan Feng, Deng Rong, Jun-Dong Li, Xiao-Feng Zhu
Publikováno v:
International Journal of Biological Sciences. 19:1846-1860
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1462d396307dcf1658161c5f747431b7
https://doi.org/10.7150/ijbs.79654
https://doi.org/10.7150/ijbs.79654
Autor:
Xuan Li, Xiao-Qi Wu, Rong Deng, Dan-Dan Li, Jun Tang, Wen-Dan Chen, Jing-Hong Chen, Jiao Ji, Lin Jiao, Shan Jiang, Fen Yang, Gong-Kan Feng, Ravichandran Senthilkumar, Fei Yue, Hai-Liang Zhang, Rui-Yan Wu, Yan Yu, Xue-Lian Xu, Jia Mai, Zhi-Ling Li, Xiao-Dan Peng, Yun Huang, Xiang Huang, Ning-Fang Ma, Qian Tao, Yi-Xin Zeng, Xiao-Feng Zhu
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
Neuroblastoma cell differentiation is regulated by Id proteins. Here, the authors show that CaMKII-mediated phosphorylation of Beclin 1 can activate K63-linked ubiquitination and autophagic degradation of Id proteins uncovering a role for autophagy i
Externí odkaz:
https://doaj.org/article/efa154aa063f4ab3b297d24aa034cdbf