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Multidimensional analysis of the impact of Gemmatimonas, Rhodothermus, and Sutterella on drug and treatment response in colorectal cancer

Autor: Shaowen Jin, Wa Zhong, Bo Li, Kaimei Wang, Dongming Lai

Publikováno v: Frontiers in Cellular and Infection Microbiology, Vol 14 (2024)

BackgroundColorectal cancer is the third most prevalent cancer across the globe. Despite a diversity of treatment methods, the recurrence and mortality rates of the disease remain high. Recent studies have revealed a close association of the gut micr

Externí odkaz: https://doaj.org/article/be7f16ccd3ad485985faa0950dc59a08

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Akademický článek

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Akademický článek

A Missense Variant in Granulysin is Associated with the Efficacy of Pegylated-Interferon-Alpha Therapy in Chinese Patients with HBeAg-Positive Chronic Hepatitis B

Autor: Li J, Chen H, Chen J, Zhou B, Hou J, Jiang DK

Publikováno v: Pharmacogenomics and Personalized Medicine, Vol Volume 14, Pp 1505-1515 (2021)

Jing Li,1,* Haitao Chen,1,2,* Jiaxuan Chen,1,* Bin Zhou,1 Jinlin Hou,1 De-Ke Jiang1 1State Key Laboratory of Organ Failure Research, Guangdong Key Laboratory of Viral Hepatitis Research, Guangdong Institute of Liver Diseases, Department o

Externí odkaz: https://doaj.org/article/2ef7983201c24d5987b8832f897f9b8d

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Akademický článek

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Akademický článek

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mTOR activation in CD8+ cells contributes to disease activity of rheumatoid arthritis and increases therapeutic response to TNF inhibitors

Autor: Mingzeng Zhang, Shigeru Iwata, Koshiro Sonomoto, Masanobu Ueno, Yuya Fujita, Junpei Anan, Yusuke Miyazaki, Naoaki Ohkubo, Maiko Hajime Sumikawa, Yasuyuki Todoroki, Hiroko Miyata, Atsushi Nagayasu, Ryuichiro Kanda, He Hao, Gulzhan Trimova, Seunghyun Lee, Shingo Nakayamada, Kei Sakata, Yoshiya Tanaka

Publikováno v: Rheumatology. 61:3010-3022

ObjectiveThis study aimed to understand the role of mammalian target of rapamycin (mTOR) in CD8+ cells in the pathogenicity of RA and the changes after treatment with biologic drugs.MethodsPeripheral blood mononuclear cells (PBMCs) were isolated from

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32a48077e13e3289e67adc54a8f96926
https://doi.org/10.1093/rheumatology/keab834

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Peripheral CD8+ T cell characteristics associated with durable responses to immune checkpoint blockade in patients with metastatic melanoma

Autor: Julian C. Knight, Isar Nassiri, Miranda Payne, S Danielli, Paul Klenerman, Robert A. Watson, Chelsea A Taylor, Rosalin Cooper, Benjamin P. Fairfax, Zoë C. Traill, E Mahe, Hai Fang, Mark R. Middleton, Hussein Al-Mossawi, Victoria K Woodcock

Publikováno v: Nature medicine

Immune checkpoint blockade (ICB) of PD-1 and CTLA-4 to treat metastatic melanoma (MM) has variable therapeutic benefit. To explore this in peripheral samples, we characterized CD8+ T cell gene expression across a cohort of patients with MM receiving

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b4d70fa6a9a24476a3b000287fe0bd4
http://europepmc.org/articles/PMC7611047

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Probing infectious disease by single-cell RNA sequencing: Progresses and perspectives

Autor: Qian Gao, Bo Yan, Geyang Luo, Shuye Zhang

Publikováno v: Computational and Structural Biotechnology Journal
Computational and Structural Biotechnology Journal, Vol 18, Iss, Pp 2962-2971 (2020)

The increasing application of single-cell RNA sequencing (scRNA-seq) technology in life science and biomedical research has significantly increased our understanding of the cellular heterogeneities in immunology, oncology and developmental biology. T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adcea929efae2a79c6e83f039420cd4a
https://doi.org/10.1016/j.csbj.2020.10.016

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A Missense Variant in Granulysin is Associated with the Efficacy of Pegylated-Interferon-Alpha Therapy in Chinese Patients with HBeAg-Positive Chronic Hepatitis B

Autor: Jiaxuan Chen, Bin Zhou, Jinlin Hou, Jing Li, Haitao Chen, Deke Jiang

Publikováno v: Pharmacogenomics and Personalized Medicine

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d77a07fac6ca1e0c9cc69c73f0e38c5d
https://www.dovepress.com/a-missense-variant-in-granulysin-is-associated-with-the-efficacy-of-pe-peer-reviewed-fulltext-article-PGPM

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Identification of Diagnostic Signatures and Immune Cell Infiltration Characteristics in Rheumatoid Arthritis by Integrating Bioinformatic Analysis and Machine-Learning Strategies

Autor: Xu Hong, Jiayu Zhang, Youguang Zhuo, Jie Ye, Rongguo Yu, Susu Tang, Yiyuan Zhang

Publikováno v: Frontiers in Immunology, Vol 12 (2021)
Frontiers in Immunology

BackgroundRheumatoid arthritis (RA) refers to an autoimmune rheumatic disease that imposes a huge burden on patients and society. Early RA diagnosis is critical to preventing disease progression and selecting optimal therapeutic strategies more effec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b4505b5313d636d7ec761be4298525b
https://www.frontiersin.org/articles/10.3389/fimmu.2021.724934/full

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