Zobrazeno 1 - 10
of 158
pro vyhledávání: '"GMP manufacturing"'
Autor:
Matthew Bauler, Francesca Ferrara, Brandon Lowe, Jordan A. Beard, Chris Wincek, Matthew M. Wielgosz, Jeoungeun J. Park, Na Shang, Saikat Nandy, Cai Li, Deanna M. Langfitt, Sheng Zhou, Robert E. Throm
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 32, Iss 2, Pp 101270- (2024)
Successful cell and gene therapy clinical trials have resulted in the US Food and Drug Administration and European Medicines Agency approving their use for treatment of patients with certain types of cancers and monogenetic diseases. These novel ther
Externí odkaz:
https://doaj.org/article/9d1dc059d1bc47cf8fa9972dc0d7bc28
Autor:
B. Kuebler, B. Alvarez-Palomo, B. Aran, J. Castaño, L. Rodriguez, A. Raya, S. Querol Giner, A. Veiga
Publikováno v:
Stem Cell Research & Therapy, Vol 14, Iss 1, Pp 1-12 (2023)
Abstract Background Induced pluripotent stem cell (iPSC)-derived cell therapies are an interesting new area in the field of regenerative medicine. One of the approaches to decrease the costs of iPSC-derived therapies is the use of allogenic homozygou
Externí odkaz:
https://doaj.org/article/3d44c345515c4887b01986b604011220
Autor:
Ainitze Gereka, Uzuri Urtaza, Pablo Larreategi, Felipe Prosper, Enrique José Andreu, Ane Miren Zaldua
Publikováno v:
Bioengineering, Vol 11, Iss 8, p 785 (2024)
A novel, user-friendly bioreactor for the cultivation of cellularised membranes for tissue engineering has been successfully designed, manufactured, and validated. This bioreactor features a culture vessel and a cover, the latter equipped with one or
Externí odkaz:
https://doaj.org/article/0b43e3e6b39d47228871f2b003b03c0c
Autor:
Agnieszka Stawarska, Magdalena Bamburowicz-Klimkowska, Elise Runden-Pran, Maria Dusinska, Mihaela Roxana Cimpan, Ivan Rios-Mondragon, Ireneusz P. Grudzinski
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 12, p 6533 (2024)
Extracellular vesicles (EVs) hold great promise for clinical application as new diagnostic and therapeutic modalities. This paper describes major GMP-based upstream and downstream manufacturing processes for EV large-scale production, also focusing o
Externí odkaz:
https://doaj.org/article/a04fa531eaa94633955511adb052e962
Autor:
Kassandra J. Baron, Hēth R. Turnquist
Publikováno v:
Organogenesis, Vol 19, Iss 1 (2023)
ABSTRACTBased on successes in preclinical animal transplant models, adoptive cell therapy (ACT) with regulatory T cells (Tregs) is a promising modality to induce allograft tolerance or reduce the use of immunosuppressive drugs to prevent rejection. E
Externí odkaz:
https://doaj.org/article/89c8e652515c45e7bca87b5ca3b59f0d
Autor:
Belén Álvarez-Palomo, Anna Veiga, Angel Raya, Margarita Codinach, Silvia Torrents, Laura Ponce Verdugo, Clara Rodriguez-Aierbe, Leopoldo Cuellar, Raquel Alenda, Cristina Arbona, Dolores Hernández-Maraver, Cristina Fusté, Sergi Querol
Publikováno v:
Stem Cell Research & Therapy, Vol 13, Iss 1, Pp 1-11 (2022)
Abstract Background The increasing number of clinical trials for induced pluripotent stem cell (iPSC)-derived cell therapy products makes the production on clinical grade iPSC more and more relevant and necessary. Cord blood banks are an ideal source
Externí odkaz:
https://doaj.org/article/d209cf18fb39416eacd89137cc97301a
Akademický článek
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Autor:
Jara J. Joedicke, Ulrich Großkinsky, Kerstin Gerlach, Annette Künkele, Uta E. Höpken, Armin Rehm
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 24, Iss , Pp 181-198 (2022)
The advent of CAR T cells targeting CD19 or BCMA on B cell neoplasm demonstrated remarkable efficacy, but rapid relapses and primary refractoriness remains challenging. A leading cause of CAR T cell failure is their lack of expansion and limited pers
Externí odkaz:
https://doaj.org/article/8e9ad936d0d54e4e84ce45152511eebf
Akademický článek
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Akademický článek
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