Zobrazeno 1 - 10
of 12
pro vyhledávání: '"GMP, guanosine monophosphate"'
Autor:
Lu Tian, Wanfang Li, Jinfeng Wei, Zhi Zhou, Yanhua Chen, Zhonghua Wang, Wenqing Fu, Yaqi Liu, Baili Wang, Bingshu He, Meiling Huo, Jianzhen Xia, Zeper Abliz
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 11, Iss 11, Pp 3665-3677 (2021)
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica. B
Detailed knowledge on tissue-specific metabolic reprogramming in diabetic nephropathy (DN) is vital for more accurate understanding the molecular pathological signature and developing novel therapeutic strategies. In the present study, a spatial-reso
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e36a0724bd8a167963aba4a72cb2332
http://www.sciencedirect.com/science/article/pii/S2211383521001799
http://www.sciencedirect.com/science/article/pii/S2211383521001799
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 10, Iss 12, Pp 2272-2298 (2020)
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica. B
Multiple cancer immunotherapies including chimeric antigen receptor T cell and immune checkpoint inhibitors (ICIs) have been successfully developed to treat various cancers by motivating the adaptive anti-tumor immunity. Particularly, the checkpoint
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c604607610f05b2d37da5b2cce00382
http://www.sciencedirect.com/science/article/pii/S2211383519316946
http://www.sciencedirect.com/science/article/pii/S2211383519316946
Autor:
Jifang Sheng, Silan Gu, Wenrui Wu, Yingfeng Lu, Yanfei Chen, Lanjuan Li, Jiaojiao Xie, Ren Yan, Longxian Lv, Yi-Ling Du, Ding Shi, Huiyong Jiang, Kaijin Xu, Jiafeng Xia, Jing Guo, Chenjie Huang
Publikováno v:
Metabolism
Background Metabolism is critical for sustaining life, immunity and infection, but its role in COVID-19 is not fully understood. Methods Seventy-nine COVID-19 patients, 78 healthy controls (HCs) and 30 COVID-19-like patients were recruited in a prosp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32d16213af8e1fb39f4830ac48025801
http://europepmc.org/articles/PMC7920809
http://europepmc.org/articles/PMC7920809
Autor:
Xavier de Lamballerie, Bruno Canard, Ernest A. Gould, Erika J. Mancini, Rene Assenberg, Silvia Speroni, Hélène Malet, Gregory Moureau, Anna M. Jansson, Martino Bolognesi, Barbara Selisko, Johan Neyts, Rolf Hilgenfeld, Michela Bollati, Jonathan M. Grimes, Raymond J. Owens, David I. Stuart, Bruno Coutard, Mario Milani, Holger Steuber, Andrea Mattevi, Eloise Mastrangelo, Jingshan Ren, Cécile Baronti, Etienne Decroly, Torsten Unge, Karin Alvarez, Shelley Cook, Gilda Grard
Publikováno v:
Antiviral Research
Antiviral research
87 (2010): 125–148. doi:10.1016/j.antiviral.2009.11.009
info:cnr-pdr/source/autori:Bollati M.; K. Alvarez; R. Assenberg; C. Baronti; B. Canard; S. Cook; B. Coutard; E. Decroly; X. de Lamballerie; E.A. Gould; G. Grard; J.M. Grimes; R. Hilgenfeld; A.M. Jansson; H. Malet; E.J. Mancini; E. Mastrangelo; A. Mattevi; M. Milani; G. Moureau, J./titolo:Structure and functionality in flavivirus NS-proteins: Perspectives for drug design/doi:10.1016%2Fj.antiviral.2009.11.009/rivista:Antiviral research (Print)/anno:2010/pagina_da:125/pagina_a:148/intervallo_pagine:125–148/volume:87
Antiviral research
87 (2010): 125–148. doi:10.1016/j.antiviral.2009.11.009
info:cnr-pdr/source/autori:Bollati M.; K. Alvarez; R. Assenberg; C. Baronti; B. Canard; S. Cook; B. Coutard; E. Decroly; X. de Lamballerie; E.A. Gould; G. Grard; J.M. Grimes; R. Hilgenfeld; A.M. Jansson; H. Malet; E.J. Mancini; E. Mastrangelo; A. Mattevi; M. Milani; G. Moureau, J./titolo:Structure and functionality in flavivirus NS-proteins: Perspectives for drug design/doi:10.1016%2Fj.antiviral.2009.11.009/rivista:Antiviral research (Print)/anno:2010/pagina_da:125/pagina_a:148/intervallo_pagine:125–148/volume:87
Flaviviridae are small enveloped viruses hosting a positive-sense single-stranded RNA genome. Besides yellow fever virus, a landmark case in the history of virology, members of the Flavivirus genus, such as West Nile virus and dengue virus, are incre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3100478119ff8862457b51960b0d0797
https://doi.org/10.1016/j.antiviral.2009.11.009
https://doi.org/10.1016/j.antiviral.2009.11.009
Autor:
Acheson, D.W.K.
Publikováno v:
Encyclopedia of Microbiology
There are many different biological, chemical, or radiological agents that when added to food can result in many different types of illness. Some may be rapidly fatal; others require long-term exposure to result in illness. Some lead to short-term il
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmc_________::6e3eee650bc27b65fcf5bc3a332dcef9
http://europepmc.org/articles/PMC7173519
http://europepmc.org/articles/PMC7173519
Publikováno v:
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 5, Iss 3, Pp 223-230 (2015)
Acta Pharmaceutica Sinica B, Vol 5, Iss 3, Pp 223-230 (2015)
Nucleotide pools in mammalian cells change due to the influence of antitumor drugs, which may help in evaluating the drug effect and understanding the mechanism of drug action. In this study, an ion-pair RP-HPLC method was used for a simple, sensitiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e4570a8b7fa77c93ff61bd2d9a519b1
https://pubmed.ncbi.nlm.nih.gov/26579450
https://pubmed.ncbi.nlm.nih.gov/26579450
Autor:
Mario Milani, Martino Bolognesi, Barbara Selisko, Bruno Canard, Michela Bollati, Mickaël Bouvet, Eloise Mastrangelo, Etienne Decroly
Publikováno v:
Antiviral Research
Antiviral research
83 (2009): 28–34. doi:10.1016/j.antiviral.2009.03.001
info:cnr-pdr/source/autori:Milani M; Mastrangelo E; Bollati M; Selisko B; Decroly E; Bouvet M; Canard B; Bolognesi M/titolo:Flaviviral methyltransferase%2FRNA interaction: structural basis for enzyme inhibition./doi:10.1016%2Fj.antiviral.2009.03.001/rivista:Antiviral research (Print)/anno:2009/pagina_da:28/pagina_a:34/intervallo_pagine:28–34/volume:83
Antiviral research
83 (2009): 28–34. doi:10.1016/j.antiviral.2009.03.001
info:cnr-pdr/source/autori:Milani M; Mastrangelo E; Bollati M; Selisko B; Decroly E; Bouvet M; Canard B; Bolognesi M/titolo:Flaviviral methyltransferase%2FRNA interaction: structural basis for enzyme inhibition./doi:10.1016%2Fj.antiviral.2009.03.001/rivista:Antiviral research (Print)/anno:2009/pagina_da:28/pagina_a:34/intervallo_pagine:28–34/volume:83
Flaviviruses are the causative agents of severe diseases such as Dengue or Yellow fever. The replicative machinery used by the virus is based on few enzymes including a methyltransferase, located in the N-terminal domain of the NS5 protein. Flavivira
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76bba66e0e429c26c0234d783472694e
https://pubmed.ncbi.nlm.nih.gov/19501254
https://pubmed.ncbi.nlm.nih.gov/19501254
Autor:
Wang Z; Key Laboratory of Mass Spectrometry Imaging and Metabolomics (Minzu University of China), National Ethnic Affairs Commission, Beijing 100081, China.; College of Life and Environmental Sciences, Minzu University of China, Beijing 100081, China.; Key Laboratory of Ethnomedicine of Ministry of Education, School of Pharmacy, Minzu University of China, Beijing 100081, China., Fu W; Key Laboratory of Mass Spectrometry Imaging and Metabolomics (Minzu University of China), National Ethnic Affairs Commission, Beijing 100081, China.; College of Life and Environmental Sciences, Minzu University of China, Beijing 100081, China., Huo M; Key Laboratory of Mass Spectrometry Imaging and Metabolomics (Minzu University of China), National Ethnic Affairs Commission, Beijing 100081, China.; College of Life and Environmental Sciences, Minzu University of China, Beijing 100081, China., He B; College of Life and Environmental Sciences, Minzu University of China, Beijing 100081, China., Liu Y; College of Life and Environmental Sciences, Minzu University of China, Beijing 100081, China., Tian L; New Drug Safety Evaluation Center, Institute of Materia Medica, Peking Union Medical College, Beijing 100050, China., Li W; New Drug Safety Evaluation Center, Institute of Materia Medica, Peking Union Medical College, Beijing 100050, China., Zhou Z; Key Laboratory of Mass Spectrometry Imaging and Metabolomics (Minzu University of China), National Ethnic Affairs Commission, Beijing 100081, China.; College of Life and Environmental Sciences, Minzu University of China, Beijing 100081, China., Wang B; School Hospital, Minzu University of China, Beijing 100081, China., Xia J; School Hospital, Minzu University of China, Beijing 100081, China., Chen Y; Key Laboratory of Mass Spectrometry Imaging and Metabolomics (Minzu University of China), National Ethnic Affairs Commission, Beijing 100081, China.; College of Life and Environmental Sciences, Minzu University of China, Beijing 100081, China., Wei J; New Drug Safety Evaluation Center, Institute of Materia Medica, Peking Union Medical College, Beijing 100050, China., Abliz Z; Key Laboratory of Mass Spectrometry Imaging and Metabolomics (Minzu University of China), National Ethnic Affairs Commission, Beijing 100081, China.; College of Life and Environmental Sciences, Minzu University of China, Beijing 100081, China.; Key Laboratory of Ethnomedicine of Ministry of Education, School of Pharmacy, Minzu University of China, Beijing 100081, China.
Publikováno v:
Acta pharmaceutica Sinica. B [Acta Pharm Sin B] 2021 Nov; Vol. 11 (11), pp. 3665-3677. Date of Electronic Publication: 2021 May 20.
Autor:
Ding C; Research Laboratory of Medicinal Chemical Biology & Frontiers on Drug Discovery (RLMCBFDD), School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, China.; CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica (SIMM), Chinese Academy of Sciences, Shanghai 201203, China.; University of Chinese Academy of Sciences, Beijing 100049, China., Song Z; CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica (SIMM), Chinese Academy of Sciences, Shanghai 201203, China.; University of Chinese Academy of Sciences, Beijing 100049, China., Shen A; CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica (SIMM), Chinese Academy of Sciences, Shanghai 201203, China.; University of Chinese Academy of Sciences, Beijing 100049, China., Chen T; CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica (SIMM), Chinese Academy of Sciences, Shanghai 201203, China.; University of Chinese Academy of Sciences, Beijing 100049, China., Zhang A; Research Laboratory of Medicinal Chemical Biology & Frontiers on Drug Discovery (RLMCBFDD), School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, China.; CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica (SIMM), Chinese Academy of Sciences, Shanghai 201203, China.; University of Chinese Academy of Sciences, Beijing 100049, China.
Publikováno v:
Acta pharmaceutica Sinica. B [Acta Pharm Sin B] 2020 Dec; Vol. 10 (12), pp. 2272-2298. Date of Electronic Publication: 2020 Mar 13.
Autor:
Croteau D; Cardiovascular Medicine Section and Myocardial Biology Unit, Boston University School of Medicine, Boston, Massachusetts., Qin F; Cardiovascular Medicine Section and Myocardial Biology Unit, Boston University School of Medicine, Boston, Massachusetts., Chambers JM; Cardiovascular Medicine Section and Myocardial Biology Unit, Boston University School of Medicine, Boston, Massachusetts., Kallick E; Cardiovascular Medicine Section and Myocardial Biology Unit, Boston University School of Medicine, Boston, Massachusetts., Luptak I; Cardiovascular Medicine Section and Myocardial Biology Unit, Boston University School of Medicine, Boston, Massachusetts., Panagia M; Cardiovascular Medicine Section and Myocardial Biology Unit, Boston University School of Medicine, Boston, Massachusetts., Pimentel DR; Cardiovascular Medicine Section and Myocardial Biology Unit, Boston University School of Medicine, Boston, Massachusetts., Siwik DA; Cardiovascular Medicine Section and Myocardial Biology Unit, Boston University School of Medicine, Boston, Massachusetts., Colucci WS; Cardiovascular Medicine Section and Myocardial Biology Unit, Boston University School of Medicine, Boston, Massachusetts.
Publikováno v:
JACC. Basic to translational science [JACC Basic Transl Sci] 2020 Sep 09; Vol. 5 (9), pp. 916-927. Date of Electronic Publication: 2020 Sep 09 (Print Publication: 2020).