Alpha-Synuclein and GM1 Ganglioside Co-Localize in Neuronal Cytosol Leading to Inverse Interaction—Relevance to Parkinson's Disease.

Autor: Kumar, Ranjeet¹ (AUTHOR) ranjeet.kumar1@rutgers.edu, Chowdhury, Suman¹ (AUTHOR), Ledeen, Robert¹ (AUTHOR) ledeenro@njms.rutgers.edu

Publikováno v: International Journal of Molecular Sciences. Mar2024, Vol. 25 Issue 6, p3323. 13p.

GM1 Oligosaccharide Ameliorates Rett Syndrome Phenotypes In Vitro and In Vivo via Trk Receptor Activation.

Autor: Fazzari, Maria¹ (AUTHOR) giulia.lunghi@unimi.it, Lunghi, Giulia¹ (AUTHOR) emma.carsana@unimi.it, Carsana, Emma Veronica¹ (AUTHOR) manuela.valsecchi@unimi.it, Valsecchi, Manuela¹ (AUTHOR) eleonora.spiombi@gmail.com, Spiombi, Eleonora¹ (AUTHOR) martina.breccia@unimi.it, Breccia, Martina¹ (AUTHOR) silvia.casati@unimi.it, Casati, Silvia Rosanna¹ (AUTHOR) laura.mauri@unimi.it, Pedretti, Silvia² (AUTHOR) silvia.pedretti@unimi.it, Mitro, Nico^2,3 (AUTHOR) nico.mitro@unimi.it, Mauri, Laura¹ (AUTHOR) maria.ciampa@unimi.it, Ciampa, Maria Grazia¹ (AUTHOR) sandro.sonnino@unimi.it, Sonnino, Sandro¹ (AUTHOR) nicoletta.landsberger@unimi.it, Landsberger, Nicoletta¹ (AUTHOR) angelisa.frasca@unimi.it, Frasca, Angelisa¹ (AUTHOR), Chiricozzi, Elena¹ (AUTHOR) maria.fazzari@unimi.it

Publikováno v: International Journal of Molecular Sciences. Nov2024, Vol. 25 Issue 21, p11555. 21p.

Creation of an in vitro model of GM1 gangliosidosis by CRISPR/Cas9 knocking-out the GLB1 gene in SH-SY5Y human neuronal cell line.

Autor: Hosseini K; Department of Molecular Medicine, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Iran., Fallahi J; Department of Molecular Medicine, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Iran., Aligholi H; Department of Neuroscience, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Iran., Heidari Z; Department of Molecular Medicine, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Iran., Nadimi E; Department of Molecular Medicine, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Iran., Safari F; Diagnostic Laboratory Sciences and Technology Research Center, School of Paramedical Sciences, Shiraz University of Medical Sciences, Shiraz, Iran., Sisakht M; Department of Molecular Medicine, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Iran., Atapour A; Department of Medical Biotechnology, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Iran., Khajeh S; Bone and Joint Diseases Research Center, Shiraz University of Medical Sciences, Shiraz, Iran., Tabei SMB; Department of Medical Genetics, School of Medical Sciences, Shiraz University of Medical Sciences, Shiraz, Iran., Razban V; Department of Molecular Medicine, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Iran.; Stem Cells Technology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.

Publikováno v: Cell biochemistry and function [Cell Biochem Funct] 2024 Aug; Vol. 42 (6), pp. e4102.

GM1 gangliosidosis type II: Results of a 10-year prospective study.

Autor: D'Souza P; Office of the Clinical Director, National Human Genome Research Institute, Bethesda, MD; Medical Genetics Branch, National Human Genome Research Institute, Bethesda, MD., Farmer C; Neurodevelopmental and Behavioral Phenotyping Service, National Institute of Mental Health, Bethesda, MD., Johnston JM; Office of the Clinical Director, National Human Genome Research Institute, Bethesda, MD; Medical Genetics Branch, National Human Genome Research Institute, Bethesda, MD., Han ST; Medical Genetics Branch, National Human Genome Research Institute, Bethesda, MD., Adams D; Office of the Clinical Director, National Human Genome Research Institute, Bethesda, MD., Hartman AL; Division of Clinical Research, National Institute of Neurological Disorders and Stroke, Bethesda, MD., Zein W; Ophthalmic Genetics and Visual Function Branch, National Eye Institute, Bethesda, MD., Huryn LA; Ophthalmic Genetics and Visual Function Branch, National Eye Institute, Bethesda, MD., Solomon B; Rehabilitation Medicine Department, Warren C. Magnuson Clinical Research Center, Bethesda, MD., King K; Neurology Branch, National Institute on Deafness and Other Communication Disorders, Bethesda, MD., Jordan CP; Cardiology Department, Inova Children's Hospital, Fairfax, VA., Myles J; Nutrition Department, Warren C. Magnuson Clinical Research Center, Bethesda, MD., Nicoli ER; Office of the Clinical Director, National Human Genome Research Institute, Bethesda, MD; Medical Genetics Branch, National Human Genome Research Institute, Bethesda, MD., Rothermel CE; Office of the Clinical Director, National Human Genome Research Institute, Bethesda, MD; Medical Genetics Branch, National Human Genome Research Institute, Bethesda, MD., Mojica Algarin Y; Office of the Clinical Director, National Human Genome Research Institute, Bethesda, MD; Medical Genetics Branch, National Human Genome Research Institute, Bethesda, MD., Huang R; Office of the Clinical Director, National Human Genome Research Institute, Bethesda, MD; Medical Genetics Branch, National Human Genome Research Institute, Bethesda, MD., Quimby R; Office of the Clinical Director, National Human Genome Research Institute, Bethesda, MD; Medical Genetics Branch, National Human Genome Research Institute, Bethesda, MD., Zainab M; Office of the Clinical Director, National Human Genome Research Institute, Bethesda, MD; Medical Genetics Branch, National Human Genome Research Institute, Bethesda, MD., Bowden S; Office of the Clinical Director, National Human Genome Research Institute, Bethesda, MD; Medical Genetics Branch, National Human Genome Research Institute, Bethesda, MD., Crowell A; Office of the Clinical Director, National Human Genome Research Institute, Bethesda, MD; Medical Genetics Branch, National Human Genome Research Institute, Bethesda, MD., Buckley A; Sleep and Neurodevelopment Service, National Institute of Mental Health, Bethesda, MD., Brewer C; Neurology Branch, National Institute on Deafness and Other Communication Disorders, Bethesda, MD., Regier DS; Genetics and Metabolism, Children's National Hospital, Washington, DC., Brooks BP; Ophthalmic Genetics and Visual Function Branch, National Eye Institute, Bethesda, MD., Acosta MT; Undiagnosed Disease Program, National Human Genome Research Institute, Bethesda, MD., Baker EH; Department of Radiology and Imaging Sciences, National Institutes of Health Clinical Center, Bethesda, MD., Vézina G; Program in Neuroradiology and Program in Radiology, Children's National Hospital, Washington, DC; Radiology and Pediatrics, The George Washington University School of Medicine and Health Sciences, Washington, DC., Thurm A; Neurodevelopmental and Behavioral Phenotyping Service, National Institute of Mental Health, Bethesda, MD., Tifft CJ; Office of the Clinical Director, National Human Genome Research Institute, Bethesda, MD; Medical Genetics Branch, National Human Genome Research Institute, Bethesda, MD. Electronic address: cynthia.tifft@nih.gov.

Publikováno v: Genetics in medicine : official journal of the American College of Medical Genetics [Genet Med] 2024 Jul; Vol. 26 (7), pp. 101144. Date of Electronic Publication: 2024 Apr 16.

Preferential Regulation of Γ‐Secretase‐Mediated Cleavage of APP by Ganglioside GM1 Reveals a Potential Therapeutic Target for Alzheimer's Disease.

Autor: Wang, Xiaotong^1,2 (AUTHOR), Zhou, Rui³ (AUTHOR) zr2020@tsinghua.edu.cn, Sun, Xiaqin¹ (AUTHOR), Li, Jun¹ (AUTHOR), Wang, Jinxin⁴ (AUTHOR), Yue, Weihua^1,5 (AUTHOR), Wang, Lifang¹ (AUTHOR), Liu, Hesheng^2,6 (AUTHOR), Shi, Yigong^3,7,8,9 (AUTHOR), Zhang, Dai^1,2 (AUTHOR) daizhang@bjmu.edu.cn

Publikováno v: Advanced Science. 11/14/2023, Vol. 10 Issue 32, p1-12. 12p.