Zobrazeno 1 - 10
of 74
pro vyhledávání: '"GM Boxer"'
Autor:
R Boden, AA Flynn, GM Boxer, Jason L. J. Dearling, J Bhatia, R. H. J. Begent, AJ Green, RB Pedley
Publikováno v:
International Journal of Radiation Biology. 77:507-517
To develop a model that relates the pattern of dose delivery during radio-immunotherapy to biological effect. This model was used to assess the efficacy of a range of antibodies labelled with 131I, 186Re and 90Y.Pharmacokinetic data were obtained by
Autor:
J Bhatia, R. H. J. Begent, A. Huhalov, SP Cooke, GM Boxer, RB Pedley, Surinder K. Sharma, A Mayer, Lisa Robson, KA Chester, AA Flynn, Dir Spencer
Publikováno v:
Disease Markers, Vol 16, Iss 1-2, Pp 53-62 (2000)
Disease Markers
Disease Markers
Single chain Fv antibodies (sFvs) have been produced from filamentous bacteriophage libraries obtained from immunised mice. MFE-23, the most characterised of these sFvs, is reactive with carcinoembryonic antigen (CEA), a glycoprotein that is highly e
Publikováno v:
Physics in Medicine and Biology. 44:N151-N159
Image registration is a powerful tool for correlating functional images with images of anatomical structure. This facilitates more accurate quantitation of regional radiopharmaceutical uptake. Similarly, registration of images of radiolabelled antibo
Publikováno v:
International Journal of Cancer. 57:830-835
Radioimmunotherapy (RIT) is hampered clinically by poor tumour localization of antibody. In order to enhance localization we have investigated the concomitant use of RIT with 2 drugs, fiavone-8-acetic acid (FAA) and its analogue 5,6-dimethylxanthenon
Autor:
Robert E. Hawkins, P. A. Keep, KA Chester, Richard H. J. Begent, RB Pedley, J. A. Boden, Lisa Robson, GM Boxer
Publikováno v:
International Journal of Cancer. 57:67-72
A recombinant chimeric Fab (rcFab), with Fv derived from the monoclonal A5B7 antibody to carcinoembryonic antigen (CEA), and with human CHI and C kappa was cloned into pUC 19 and expressed in Escherichia coli. rcFab (10 to 12 mg per litre) was produc
Publikováno v:
British Journal of Cancer
Antibody targeting has potential for selective delivery of cancer therapy. However, there is a wide variation in the degree of antibody localisation in individual patients with colorectal adenocarcinoma. Colorectal adenocarcinomas are composed of gla
Autor:
Alan D. B. Malcolm, Richard H. J. Begent, GM Boxer, A. J. S. Macpherson, KA Chester, A. M. Abbasi
Publikováno v:
The Journal of Pathology. 168:405-411
Carcinoembryonic antigen (CEA) mRNA expression was studied in 14 cases of normal colorectal mucosa and colonic adenocarcinomas using in situ hybridization with a P-32-labelled cDNA probe to the unique 3'-untranslated region of CEA. This approach has
Autor:
R. H. J. Begent, Amb Kelly, S. B. Blair, GM Boxer, P. M. Dawson, J. A. Ledermann, N. A. Theodorou, P. J. Southall
Publikováno v:
British Journal of Cancer
Tumour localisation of anti-tumour antibodies varies greatly between patients. Factors which may be responsible for this have been investigated in 56 patients with colorectal carcinoma with a view to improving radioimmunotherapy. Thirty-seven to seve
Autor:
Ian C. Talbot, H. Pringle, KA Chester, Lisa Robson, GM Boxer, A. J. S. Macpherson, Richard H. J. Begent, S. L. Owen, Alan D. B. Malcolm, L Primrose
Publikováno v:
The Journal of Pathology. 162:309-315
cDNA clones of mRNAs with an abnormal abundance in familial adenomatous polyposis were used to examine the levels and distribution of the mRNAs in tissues from 15 patients with colorectal cancer. Of 12 cloned sequences studied by slot hybridization,
Autor:
P. M. Dawson, R. H. J. Begent, P. Southall, S. J. Riggs, P. Gregory, GM Boxer, N. A. Theodorou, M. Salmon, Amb Kelly, S. D. Blair
Publikováno v:
British Journal of Cancer
Local recurrence of colorectal cancer may result from failure to assess accurately the extent of tumour at operation. It has been suggested that peroperative radioimmunolocalisation may improve this assessment. The degree to which this is possible ha