Zobrazeno 1 - 10
of 74
pro vyhledávání: '"GM Boxer"'
Autor:
R Boden, AA Flynn, GM Boxer, Jason L. J. Dearling, J Bhatia, R. H. J. Begent, AJ Green, RB Pedley
Publikováno v:
International Journal of Radiation Biology. 77:507-517
To develop a model that relates the pattern of dose delivery during radio-immunotherapy to biological effect. This model was used to assess the efficacy of a range of antibodies labelled with 131I, 186Re and 90Y.Pharmacokinetic data were obtained by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e2601c7a4b2af9c7464de85544c1828
https://doi.org/10.1080/09553000010024902
https://doi.org/10.1080/09553000010024902
Autor:
J Bhatia, R. H. J. Begent, A. Huhalov, SP Cooke, GM Boxer, RB Pedley, Surinder K. Sharma, A Mayer, Lisa Robson, KA Chester, AA Flynn, Dir Spencer
Publikováno v:
Disease Markers, Vol 16, Iss 1-2, Pp 53-62 (2000)
Disease Markers
Disease Markers
Single chain Fv antibodies (sFvs) have been produced from filamentous bacteriophage libraries obtained from immunised mice. MFE-23, the most characterised of these sFvs, is reactive with carcinoembryonic antigen (CEA), a glycoprotein that is highly e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22446e1eb15da88383a201e397adf38e
https://doaj.org/article/56d7014510344703a4b095310dcc5f2b
https://doaj.org/article/56d7014510344703a4b095310dcc5f2b
Publikováno v:
Physics in Medicine and Biology. 44:N151-N159
Image registration is a powerful tool for correlating functional images with images of anatomical structure. This facilitates more accurate quantitation of regional radiopharmaceutical uptake. Similarly, registration of images of radiolabelled antibo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31a91e3453a8c5994b1c34eddd47357b
https://doi.org/10.1088/0031-9155/44/7/402
https://doi.org/10.1088/0031-9155/44/7/402
Publikováno v:
International Journal of Cancer. 57:830-835
Radioimmunotherapy (RIT) is hampered clinically by poor tumour localization of antibody. In order to enhance localization we have investigated the concomitant use of RIT with 2 drugs, fiavone-8-acetic acid (FAA) and its analogue 5,6-dimethylxanthenon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e38e6f94e52897fce9a9cdd586c8b5f1
https://doi.org/10.1002/ijc.2910570611
https://doi.org/10.1002/ijc.2910570611
Autor:
Robert E. Hawkins, P. A. Keep, KA Chester, Richard H. J. Begent, RB Pedley, J. A. Boden, Lisa Robson, GM Boxer
Publikováno v:
International Journal of Cancer. 57:67-72
A recombinant chimeric Fab (rcFab), with Fv derived from the monoclonal A5B7 antibody to carcinoembryonic antigen (CEA), and with human CHI and C kappa was cloned into pUC 19 and expressed in Escherichia coli. rcFab (10 to 12 mg per litre) was produc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a391585f95ca8c75d8a896035cadb48c
https://doi.org/10.1002/ijc.2910570113
https://doi.org/10.1002/ijc.2910570113
Publikováno v:
British Journal of Cancer
Antibody targeting has potential for selective delivery of cancer therapy. However, there is a wide variation in the degree of antibody localisation in individual patients with colorectal adenocarcinoma. Colorectal adenocarcinomas are composed of gla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d16eff021720b9da3851bfa85b5e360
https://doi.org/10.1038/bjc.1994.56
https://doi.org/10.1038/bjc.1994.56
Autor:
Alan D. B. Malcolm, Richard H. J. Begent, GM Boxer, A. J. S. Macpherson, KA Chester, A. M. Abbasi
Publikováno v:
The Journal of Pathology. 168:405-411
Carcinoembryonic antigen (CEA) mRNA expression was studied in 14 cases of normal colorectal mucosa and colonic adenocarcinomas using in situ hybridization with a P-32-labelled cDNA probe to the unique 3'-untranslated region of CEA. This approach has
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9fed745249cb90d24e4a926e0095b70
https://doi.org/10.1002/path.1711680411
https://doi.org/10.1002/path.1711680411
Autor:
R. H. J. Begent, Amb Kelly, S. B. Blair, GM Boxer, P. M. Dawson, J. A. Ledermann, N. A. Theodorou, P. J. Southall
Publikováno v:
British Journal of Cancer
Tumour localisation of anti-tumour antibodies varies greatly between patients. Factors which may be responsible for this have been investigated in 56 patients with colorectal carcinoma with a view to improving radioimmunotherapy. Thirty-seven to seve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00250f43959f840026206a08780f4299
http://europepmc.org/articles/PMC1977772
http://europepmc.org/articles/PMC1977772
Autor:
Ian C. Talbot, H. Pringle, KA Chester, Lisa Robson, GM Boxer, A. J. S. Macpherson, Richard H. J. Begent, S. L. Owen, Alan D. B. Malcolm, L Primrose
Publikováno v:
The Journal of Pathology. 162:309-315
cDNA clones of mRNAs with an abnormal abundance in familial adenomatous polyposis were used to examine the levels and distribution of the mRNAs in tissues from 15 patients with colorectal cancer. Of 12 cloned sequences studied by slot hybridization,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44833241d2c1610b4ee28bdb5eba340d
https://doi.org/10.1002/path.1711620406
https://doi.org/10.1002/path.1711620406
Autor:
P. M. Dawson, R. H. J. Begent, P. Southall, S. J. Riggs, P. Gregory, GM Boxer, N. A. Theodorou, M. Salmon, Amb Kelly, S. D. Blair
Publikováno v:
British Journal of Cancer
Local recurrence of colorectal cancer may result from failure to assess accurately the extent of tumour at operation. It has been suggested that peroperative radioimmunolocalisation may improve this assessment. The degree to which this is possible ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2638dd43fe8e18de865776903ae15ae
http://europepmc.org/articles/PMC1971674
http://europepmc.org/articles/PMC1971674