Zobrazeno 1 - 10
of 237
pro vyhledávání: '"GLYN DAWSON"'
Autor:
Miriam S. Domowicz, Wen-Ching Chan, Patricia Claudio-Vázquez, Judith G. Henry, Christopher B. Ware, Jorge Andrade, Glyn Dawson, Nancy B. Schwartz
Publikováno v:
ASN Neuro, Vol 11 (2019)
In humans, homozygous mutations in the TPP1 gene results in loss of tripeptidyl peptidase 1 (TPP1) enzymatic activity, leading to late infantile neuronal ceroid lipofuscinoses disease. Using a mouse model that targets the Tpp1 gene and recapitulates
Externí odkaz:
https://doaj.org/article/12cf30e25de040ce8b17124d7ae4ed74
Publikováno v:
Cancers, Vol 11, Iss 4, p 476 (2019)
Intercellular communication is accomplished by passage of ions and small molecules through gap junction channels in directly contacting cells or by secretion and response to transmitters, hormones and extracellular vesicles in cells that are distant
Externí odkaz:
https://doaj.org/article/2889601182dd48a293cab7484845c445
Autor:
Ryan Walters, Igor L. Medintz, James B. Delehanty, Michael H. Stewart, Kimihiro Susumu, Alan L. Huston, Philip E. Dawson, Glyn Dawson
Publikováno v:
ASN Neuro, Vol 7 (2015)
Despite our extensive knowledge of the structure of negatively charged cell surface proteoglycans and sialoglycoconjugates in the brain, we have little understanding of how their negative charge contributes to brain function. We have previously shown
Externí odkaz:
https://doaj.org/article/d64d40f456ce498fa09f89c0f8165717
Autor:
Ryan Walters, Richard P Kraig, Igor Medintz, James B Delehanty, Michael H Stewart, Kimihiro Susumu, Alan L Huston, Philip E Dawson, Glyn Dawson
Publikováno v:
ASN Neuro, Vol 4 (2012)
We have previously shown that CdSe/ZnS core/shell luminescent semiconductor nanocrystals or QDs (quantum dots) coated with PEG [poly(ethylene glycol)]-appended DHLA (dihydrolipoic acid) can bind AcWG(Pal)VKIKKP 9 GGH 6 (Palm1) through the histidine r
Externí odkaz:
https://doaj.org/article/4de718887d8044bb8c401ecc2742bc06
Autor:
Glyn Dawson
Publikováno v:
Journal of Lipid Research, Vol 13, Iss 2, Pp 207-219 (1972)
The glycosphingolipid composition of brain and visceral tissue from a patient with an unusual neurovisceral lipid storage disease, characterized by a lactosylceramide galactosyl hydrolase deficiency, was determined. Analyses of erythrocytes, plasma,
Externí odkaz:
https://doaj.org/article/21aea1d9f2024ac19215f044e81ba64e
Autor:
GLYN DAWSON, CHARLES C. SWEELEY
Publikováno v:
Journal of Lipid Research, Vol 12, Iss 1, Pp 56-64 (1971)
Microgram quantities of complex glycosphingolipids were fully trimethylsilylated and analyzed by mass spectrometry. Reproducible ratios of the intensities of certain sugar fragment ions to the total intensity of ions characteristic of the sphingolipi
Externí odkaz:
https://doaj.org/article/b17d9c006441487db1910880ebdb9068
Autor:
Glyn Dawson, Charles C. Sweeley
Publikováno v:
Journal of Lipid Research, Vol 10, Iss 4, Pp 402-405 (1969)
A method is described for the study of glycosyl ceramide glycosyl hydrolases. Problems arising from the limited solubility of glycosyl ceramides in aqueous media were overcome by coating the substrate on a filter paper disc that had been treated with
Externí odkaz:
https://doaj.org/article/8a9f855e45664603aab21014477ec843
Autor:
Glyn, Dawson
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2187
Lipid rafts (LRs) represent cellular microdomains enriched in sphingolipids and cholesterol which may fuse to form platforms in which signaling molecules can be organized and regulated (Simons and Ikonen, Nature 387:569-572, 1997; Pike, Biochem J 378
Autor:
Glyn Dawson
Publikováno v:
Methods in Molecular Biology ISBN: 9781071608135
Lipid rafts (LRs) represent cellular microdomains enriched in sphingolipids and cholesterol which may fuse to form platforms in which signaling molecules can be organized and regulated (Simons and Ikonen, Nature 387:569-572, 1997; Pike, Biochem J 378
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dcd5bb8b94ba5c512578a41bf53855df
https://doi.org/10.1007/978-1-0716-0814-2_6
https://doi.org/10.1007/978-1-0716-0814-2_6
Quantum dot‐mediated delivery of siRNA to inhibit sphingomyelinase activities in brain‐derived cells
Autor:
Jingdong Qin, James B. Delehanty, Kimihiro Susumu, Glyn Dawson, Igor L. Medintz, Ted Getz, Philip E. Dawson
Publikováno v:
Journal of Neurochemistry. 139:872-885
The use of RNAi to suppress protein synthesis offers a potential way of reducing the level of enzymes or the synthesis of mutant toxic proteins but there are few tools currently available for their delivery. To address this problem, bioconjugated qua