Alanine Scanning Mutagenesis of the C-Terminal Cytosolic End of Gpm6a Identifies Key Residues Essential for the Formation of Filopodia

Autor: Nicolás M. Rosas, Anabel Alvarez Juliá, Sofia E. Alzuri, Alberto C. Frasch, Beata Fuchsova

Publikováno v: Frontiers in Molecular Neuroscience, Vol 11 (2018)

Neuronal membrane glycoprotein M6a (Gpm6a) is a protein with four transmembrane regions and the N- and the C-ends facing the cytosol. It functions in processes of neuronal development, outgrowth of neurites, and formation of filopodia, spines, and sy

Externí odkaz: https://doaj.org/article/07b342576a4e409cb37e770de98ee27c

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Neuronal Glycoprotein M6a: An Emerging Molecule in Chemical Synapse Formation and Dysfunction

Autor: Camila Scorticati, Antonella León, Gabriela I. Aparicio

Publikováno v: Frontiers in Synaptic Neuroscience, Vol 13 (2021)
Frontiers in Synaptic Neuroscience

The cellular and molecular mechanisms underlying neuropsychiatric and neurodevelopmental disorders show that most of them can be categorized as synaptopathies—or damage of synaptic function and plasticity. Synaptic formation and maintenance are orc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73c433b52e6e43953fb2053a307ecf42
https://www.frontiersin.org/articles/10.3389/fnsyn.2021.661681/full

Search of brain-enriched proteins in salivary extracellular vesicles for their use as mental disease biomarkers: A pilot study of the neuronal glycoprotein M6a

Autor: Marcela Adriana Brocco, Natalia Catoira, S. Billi, Melisa Carolina Monteleone, Luciano Viale, Alberto C.C. Frasch

Publikováno v: CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Journal of Affective Disorders Reports, Vol 1, Iss, Pp 100003-(2020)

Background: Mental disorders affect millions of people worldwide. Their etiology is complex and the fact that the main effects occur in the brain hampers biochemical diagnosis. Therefore, biomarker finding in peripheral fluids such as serum or saliva

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9809e8154e4bd669129b16dffb149d91
https://linkinghub.elsevier.com/retrieve/pii/S2666915320300032

Construction of Gpm6a/Reelin

Autor: Jin-Li Lou, Zhong-Ping Duan, Honglin Shi, Yu Chen, Feng Ren, Hongbo Shi

Publikováno v: World Journal of Gastroenterology

AIM To prepare a Gpm6a/ReelinGFPCreERT2 construct with a rapid and reliable strategy using a bacterial artificial chromosome (BAC). METHODS Gpm6a and Reelin BACs were purified and transformed into SW102 E. coli by electroporation. The GFPCreERT2 frag

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b4416a1ee38b49ea6ca241756e562e2
https://pubmed.ncbi.nlm.nih.gov/31333318