Zobrazeno 1 - 10
of 12
pro vyhledávání: '"GLUT4, glucose transporter type 4"'
Publikováno v:
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 11, Iss 9, Pp 2749-2767 (2021)
Acta Pharmaceutica Sinica B, Vol 11, Iss 9, Pp 2749-2767 (2021)
Diabetic nephropathy (DN) has been recognized as a severe complication of diabetes mellitus and a dominant pathogeny of end-stage kidney disease, which causes serious health problems and great financial burden to human society worldwide. Conventional
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68d8ab4193adc39b242fa3c089b4f517
https://doi.org/10.1016/j.apsb.2020.12.020
https://doi.org/10.1016/j.apsb.2020.12.020
Autor:
Qiong Wang, Sigurdur Trausti Karvelsson, Aristotelis Kotronoulas, Thorarinn Gudjonsson, Skarphedinn Halldorsson, Ottar Rolfsson
Publikováno v:
Molecular & Cellular Proteomics : MCP
Breast cancer cells that have undergone partial epithelial–mesenchymal transition (EMT) are believed to be more invasive than cells that have completed EMT. To study metabolic reprogramming in different mesenchymal states, we analyzed protein expre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1a82c97a23a25ba1765695dda58542d
https://doi.org/10.1016/j.mcpro.2021.100185
https://doi.org/10.1016/j.mcpro.2021.100185
Autor:
Daniel J. Horan, Hyun Cheol Roh, Aaron C. Ericsson, Surabhi D. Abhyankar, Natalie D. Stull, Xiaocheng C. Dong, Alexander G. Robling, Hongxia Ren, Robert N. Bone, Austin M. Reilly, Shijun Yan, Jason M. Conley, Carmella Evans-Molina, Menghao Huang
Publikováno v:
The Journal of Biological Chemistry
Insulin resistance impairs postprandial glucose uptake through glucose transporter type 4 (GLUT4) and is the primary defect preceding type 2 diabetes. We previously generated an insulin-resistant mouse model with human GLUT4 promoter-driven insulin r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3a1f584191ae8f0764e128eed5d78d0
https://doi.org/10.1016/j.jbc.2021.101431
https://doi.org/10.1016/j.jbc.2021.101431
Publikováno v:
Redox Biology, Vol 12, Iss, Pp 82-102 (2017)
Redox Biology
Redox Biology
Metabolic diseases such as type 2 diabetes are a major public health issue worldwide. These diseases are often linked to a dysfunctional adipose tissue. Fat is a large, heterogenic, pleiotropic and rather complex tissue. It is found in virtually all
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df746aedd2e3f16c2a5c1aa4babe2bd5
http://www.sciencedirect.com/science/article/pii/S2213231717300447
http://www.sciencedirect.com/science/article/pii/S2213231717300447
Autor:
Punniyakoti Veeraveedu Thanikachalam, Pooja Chawla, Rahul K. Maurya, Srinivasan Ramamurthy, Garima Bansal
Publikováno v:
Journal of Advanced Research, Vol 23, Iss, Pp 163-205 (2020)
Journal of Advanced Research
Journal of Advanced Research
Graphical abstract
Highlights • TZDs, an important pharmacophore in the treatment of diabetes. • Various analog-based synthetic strategies and biological significance are discussed. • Clinical studies using TZDs along with other antidiabet
Highlights • TZDs, an important pharmacophore in the treatment of diabetes. • Various analog-based synthetic strategies and biological significance are discussed. • Clinical studies using TZDs along with other antidiabet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e5fc0ed6fb3fffcffa5bcfde8b3fa5b
https://pubmed.ncbi.nlm.nih.gov/32154036
https://pubmed.ncbi.nlm.nih.gov/32154036
Publikováno v:
Stem Cell Research
Stem Cell Research, Vol 38, Iss, Pp-(2019)
Stem Cell Research, Vol 38, Iss, Pp-(2019)
Myocardial infarction is the most prevalent of cardiovascular diseases and pharmacological interventions do not lead to restoration of the lost cardiomyocytes. Despite extensive stem cell therapy studies, clinical trials using cardiac progenitor cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::fb703eedd62258b6eca08656a3d8f477
http://ora.ox.ac.uk/objects/uuid:
http://ora.ox.ac.uk/objects/uuid:
Publikováno v:
Bioscience Reports
Bioscience Reports, Vol 32, Iss 4 (2012)
Bioscience Reports, Vol 32, Iss 4 (2012)
Intracellular membrane trafficking along endocytic and secretory transport pathways plays a critical role in diverse cellular functions including both developmental and pathological processes. Briefly, proteins and lipids destined for transport to di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79dd48eddc724916d6194c978f977303
http://europepmc.org/articles/PMC3392101
http://europepmc.org/articles/PMC3392101
Autor:
Limei, Wang, Birgit, Waltenberger, Eva-Maria, Pferschy-Wenzig, Martina, Blunder, Xin, Liu, Clemens, Malainer, Tina, Blazevic, Stefan, Schwaiger, Judith M, Rollinger, Elke H, Heiss, Daniela, Schuster, Brigitte, Kopp, Rudolf, Bauer, Hermann, Stuppner, Verena M, Dirsch, Atanas G, Atanasov
Publikováno v:
Biochemical Pharmacology
Graphical abstract
Agonists of the nuclear receptor PPARγ are therapeutically used to combat hyperglycaemia associated with the metabolic syndrome and type 2 diabetes. In spite of being effective in normalization of blood glucose levels, the cu
Agonists of the nuclear receptor PPARγ are therapeutically used to combat hyperglycaemia associated with the metabolic syndrome and type 2 diabetes. In spite of being effective in normalization of blood glucose levels, the cu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d7bd33eae8d9f01cdf1990563bf326d8
https://pubmed.ncbi.nlm.nih.gov/25083916
https://pubmed.ncbi.nlm.nih.gov/25083916
Autor:
Fang J; Department of Food Science and Technology, Zhejiang University of Technology, Zhejiang, Hangzhou 310014, China., Lin Y; Department of Food Science and Technology, Zhejiang University of Technology, Zhejiang, Hangzhou 310014, China., Xie H; Department of Food Science and Technology, Zhejiang University of Technology, Zhejiang, Hangzhou 310014, China., Farag MA; Pharmacognosy Department, College of Pharmacy, Cairo University, Kasr El Aini St., Cairo, 11562, Egypt.; Department of Chemistry, School of Science & Engineering, The American University in Cairo, New Cairo 11835, Egypt., Feng S; Department of Food Science and Technology, Zhejiang University of Technology, Zhejiang, Hangzhou 310014, China., Li J; Institute of Food Science, Zhejiang Academy of Agricultural Sciences, Hangzhou 310021, China., Shao P; Department of Food Science and Technology, Zhejiang University of Technology, Zhejiang, Hangzhou 310014, China.; Key Laboratory of Food Macromolecular Resources Processing Technology Research, China National Light Industry, Hangzhou 310021, China.
Publikováno v:
Food chemistry: X [Food Chem X] 2022 Jan 10; Vol. 13, pp. 100207. Date of Electronic Publication: 2022 Jan 10 (Print Publication: 2022).
Autor:
Tang G; School of Chinese Medicine, Li Ka Shing Faculty of Medicine, the University of Hong Kong, Hong Kong SAR 999077, China., Li S; School of Chinese Medicine, Li Ka Shing Faculty of Medicine, the University of Hong Kong, Hong Kong SAR 999077, China., Zhang C; School of Chinese Medicine, Li Ka Shing Faculty of Medicine, the University of Hong Kong, Hong Kong SAR 999077, China., Chen H; School of Chinese Medicine, Li Ka Shing Faculty of Medicine, the University of Hong Kong, Hong Kong SAR 999077, China., Wang N; School of Chinese Medicine, Li Ka Shing Faculty of Medicine, the University of Hong Kong, Hong Kong SAR 999077, China., Feng Y; School of Chinese Medicine, Li Ka Shing Faculty of Medicine, the University of Hong Kong, Hong Kong SAR 999077, China.
Publikováno v:
Acta pharmaceutica Sinica. B [Acta Pharm Sin B] 2021 Sep; Vol. 11 (9), pp. 2749-2767. Date of Electronic Publication: 2021 Feb 02.