Cardio-Oncology

Autor: Bonnie Ky, Anja Karlstaedt, Matthew Barrett, Seth Thomas Gammons, Ray Hu

Publikováno v: JACC: Basic to Translational Science

Highlights • Cancer cells can promote metabolic remodeling in the heart. • Metabolic changes provide opportunities for novel treatment strategies to prevent heart failure and monitor disease progression through new imaging techniques. • Transla

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68748cb7277a02618d388f95ef5a04f2
http://europepmc.org/articles/PMC8385559

High-resolution structures of mitochondrial glutaminase C tetramers indicate conformational changes upon phosphate binding

Autor: Thuy-Tien T. Nguyen, Sekar Ramachandran, Matthew J. Hill, Richard A. Cerione

Publikováno v: The Journal of Biological Chemistry

The mitochondrial enzyme glutaminase C (GAC) is upregulated in many cancer cells to catalyze the first step in glutamine metabolism, the hydrolysis of glutamine to glutamate. The dependence of cancer cells on this transformed metabolic pathway highli

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b92f0b609a4addf6e88c9691a5a984b
https://doi.org/10.1016/j.jbc.2022.101564

Adipocytes promote pancreatic cancer cell proliferation via glutamine transfer

Autor: Costas A. Lyssiotis, Alexandra R. Washabaugh, Carey N. Lumeng, Barbara S. Nelson, Timothy L. Frankel, Michelle L. Wynn, Kevin A. Meyer, Christopher K. Neeley, Nicki A. Baker, Robert W. O'Rourke, Andrew D. Rhim, Carmen G. Flesher

Publikováno v: Biochemistry and Biophysics Reports

Adipocytes promote progression of multiple cancers, but their role in pancreatic intraepithelial neoplasia (PanIN) and ductal adenocarcinoma (PDAC) is poorly defined. Nutrient transfer is a mechanism underlying stromal cell-cancer crosstalk. We studi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a483ec3d21987bce003f20928c324b17
https://doi.org/10.1016/j.bbrep.2016.06.004

SIRT5 regulation of ammonia-induced autophagy and mitophagy

Autor: Laura Pellegrini, Matteo Antonio Russo, Marco Tafani, Lucia Polletta, Massimo Fini, Emanuela Morgante, Enza Vernucci, Silvia Palmerio, Ilaria Carnevale, Alessandra Runci, Lidia Villanova, Luigi Sansone, Tania Arcangeli, Dante Rotili, Antonello Mai, Theresa Nowak, Clemens Steegborn, Bruna Pucci, Mike Schutkowski

Publikováno v: Autophagy

In liver the mitochondrial sirtuin, SIRT5, controls ammonia detoxification by regulating CPS1, the first enzyme of the urea cycle. However, while SIRT5 is ubiquitously expressed, urea cycle and CPS1 are only present in the liver and, to a minor exten

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::291eeba0ec2dffac9aba51bbc536950e
https://doi.org/10.1080/15548627.2015.1009778

Short-chain fatty acids reprogram metabolic profiles with the induction of reactive oxygen species production in human colorectal adenocarcinoma cells.

Autor: Huang C; State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Innovation Academy for Precision Measurement Science and Technology, Chinese Academy of Sciences, Wuhan, China., Deng W; Wuhan Botanical Garden, Chinese Academy of Sciences, Wuhan, Hubei, China., Xu HZ; Department of Pediatrics, Division of Infectious Diseases, College of Medicine, University of Florida, Gainesville, FL, USA., Zhou C; Wuhan Botanical Garden, Chinese Academy of Sciences, Wuhan, Hubei, China., Zhang F; Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China., Chen J; State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Innovation Academy for Precision Measurement Science and Technology, Chinese Academy of Sciences, Wuhan, China., Bao Q; State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Innovation Academy for Precision Measurement Science and Technology, Chinese Academy of Sciences, Wuhan, China.; University of Chinese Academy of Sciences, Beijing, China., Zhou X; State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Innovation Academy for Precision Measurement Science and Technology, Chinese Academy of Sciences, Wuhan, China.; University of Chinese Academy of Sciences, Beijing, China.; Optics Valley Laboratory, Hubei 430074, China., Liu M; State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Innovation Academy for Precision Measurement Science and Technology, Chinese Academy of Sciences, Wuhan, China.; University of Chinese Academy of Sciences, Beijing, China.; Optics Valley Laboratory, Hubei 430074, China., Li J; Wuhan Botanical Garden, Chinese Academy of Sciences, Wuhan, Hubei, China.; University of Chinese Academy of Sciences, Beijing, China., Liu C; State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Innovation Academy for Precision Measurement Science and Technology, Chinese Academy of Sciences, Wuhan, China.; University of Chinese Academy of Sciences, Beijing, China.; Optics Valley Laboratory, Hubei 430074, China.

Publikováno v: Computational and structural biotechnology journal [Comput Struct Biotechnol J] 2023 Feb 13; Vol. 21, pp. 1606-1620. Date of Electronic Publication: 2023 Feb 13 (Print Publication: 2023).