Zobrazeno 1 - 10
of 1 133
pro vyhledávání: '"GLP-1R"'
Autor:
Chenyang Liu, Qun Zhang, Hong Zhou, Linling Jin, Chang Liu, Mingxia Yang, Xinyun Zhao, Wenqiu Ding, Weiping Xie, Hui Kong
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-21 (2024)
Abstract Background Pulmonary fibrosis is a serious interstitial lung disease with no viable treatment except for lung transplantation. Glucagon-like peptide-1 receptor (GLP-1R), commonly regarded as an antidiabetic target, exerts antifibrotic effect
Externí odkaz:
https://doaj.org/article/cf5a36068247478eb83c87e47a109837
Autor:
Stav Brown, Audree B. Tadros, Giacomo Montagna, Tajah Bell, Fionnuala Crowley, Emily J. Gallagher, Joseph H. Dayan
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
PurposePatients undergoing axillary lymph node dissection (ALND) for breast cancer face a high risk of lymphedema, further increased by high body mass index (BMI) and insulin resistance. GLP-1 receptor agonists (GLP-1RAs) have the potential to reduce
Externí odkaz:
https://doaj.org/article/007f2800edd04c05b8c890eaca9b6fd6
Publikováno v:
Cell & Bioscience, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract Background Arginine vasopressin (AVP) has been reported to regulate insulin secretion and glucose homeostasis in the body. Previous study has shown that AVP and its receptor V1bR modulate insulin secretion via the hypothalamic-pituitary-adre
Externí odkaz:
https://doaj.org/article/95b44cb945604e5c80c816ffeef39c2c
Autor:
Feng Jia Nuo, Jin Tianru
Publikováno v:
Medical Review, Vol 4, Iss 4, Pp 312-325 (2024)
Incretins are gut-produced peptide-hormones that potentiate insulin secretion, especially after food intake. The concept of incretin was formed more than 100 years ago, even before insulin was isolated and utilized in the treatment of subjects with t
Externí odkaz:
https://doaj.org/article/740bcec697f4491cb0ce9ee316b55b8b
Publikováno v:
BMC Musculoskeletal Disorders, Vol 25, Iss 1, Pp 1-11 (2024)
Abstract Background This study aimed to investigate functions of GLP-1R agonist by liraglutide (LIRA) and revealing the mechanism related to AGEs/RAGE in chondrocytes. Methods To illustrate potential effect of GLP-1R agonist on AGEs induced chondrocy
Externí odkaz:
https://doaj.org/article/5e75510b896a4db6aa26d933cbcabc0c
Autor:
Daisuke Otani, Takaaki Murakami, Saeko Murakami, Ikuko Hanaoka, Hiroyuki Fujimoto, Yoichi Shimizu, Kanae Kawai Miyake, Kentaro Sakaki, Yohei Ueda, Daisuke Tanaka, Tsuyoshi Ohno, Hironori Shimizu, Naoki Uyama, Norishige Iizuka, Daisuke Yabe, Yuji Nakamoto, Nobuya Inagaki
Publikováno v:
Endocrine Journal, Vol 71, Iss 9, Pp 925-933 (2024)
Insulinomas are the most common functional pancreatic neuroendocrine neoplasm; when treatment is delayed, they induce hyperinsulinemic hypoglycemia, which is life-threatening. As surgical resection is the only curative treatment for insulinoma, preop
Externí odkaz:
https://doaj.org/article/091ae9c05e6244ff986fbdcba5b5d427
Publikováno v:
Diabetes, Metabolic Syndrome and Obesity, Vol Volume 17, Pp 2419-2456 (2024)
Joshua Reed, Stephen C Bain, Venkateswarlu Kanamarlapudi Institute of Life Science, Medical School, Swansea University, Swansea, SA2 8PP, UKCorrespondence: Venkateswarlu Kanamarlapudi, Institute of Life Science, Medical School, Swansea University, Sw
Externí odkaz:
https://doaj.org/article/46b961f9e98b4bb0ab5a50e1c0e4136f
Publikováno v:
Journal of Orthopaedic Surgery and Research, Vol 19, Iss 1, Pp 1-12 (2024)
Abstract Background Cholesterol (CHO) is an essential component of the body. However, high CHO levels in the body can damage bone mass and promote osteoporosis. CHO accumulation can cause osteoblast apoptosis, which has a negative effect on bone form
Externí odkaz:
https://doaj.org/article/556b5d2df53444e9b662809256fe3a4c
Autor:
Na Liu, Xin Cui, Wenhui Yan, Tingli Guo, Zhuanzhuan Wang, Xiaotong Wei, Yuzhuo Sun, Jieyun Liu, Cheng Xian, Weina Ma, Lina Chen
Publikováno v:
Journal of Pharmaceutical Analysis, Vol 14, Iss 8, Pp 100968- (2024)
There is increasing evidence that the activation of glucagon-like peptide-1 receptor (GLP-1R) can be used as a therapeutic intervention for cognitive disorders. Here, we have screened GLP-1R targeted compounds from Scutellaria baicalensis, which reve
Externí odkaz:
https://doaj.org/article/0b77bb30e444440c879859b2c5637d82
Autor:
Emma Barrett, Gabrielle Ivey, Adam Cunningham, Gary Coffman, Tyera Pemberton, Chan Lee, Prabir Patra, James B. Day, Peter H. U. Lee, Joon W. Shim
Publikováno v:
Frontiers in Aging Neuroscience, Vol 16 (2024)
The glucagon-like peptide-1 receptor (GLP-1R) agonists reduce glycated hemoglobin in patients with type 2 diabetes. Mounting evidence indicates that the potential of GLP-1R agonists, mimicking a 30 amino acid ligand, GLP-1, extends to the treatment o
Externí odkaz:
https://doaj.org/article/a2169a78ce0d4aaba362d9008ac9c48e