Complex interplay between epitope specificity and isotype dictates the biological activity of anti-human CD40 antibodies

Autor: Yu, X., Chan, H.T.C., Orr, C.M., Dadas, O., Booth, S.G., Dahal, L.N., Penfold, C.A., O'Brien, L., Mockridge, C.I., French, R.R., Duriez, P., Douglas, L.R., Pearson, A.R., Cragg, M.S., Tews, I., Glennie, M.J., White, A.L.

Publikováno v: 'Cancer Cell ', vol: 33, pages: 664-675 (2018)

Anti-CD40 monoclonal antibodies (mAbs) that promote or inhibit receptor function hold promise as therapeutics for cancer and autoimmunity. Rules governing their diverse range of functions, however, are lacking. Here we determined characteristics of n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=illesrfpubli::f2b08df7c2f5aa2a1ea879295763dd48
https://epn-library.esrf.fr/flora/jsp/index_view_direct_anonymous.jsp?record=doc:PUB_ESRF:49434

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Conformation of the Human Immunoglobulin G2 Hinge Imparts Superagonistic Properties to Immunostimulatory Anticancer Antibodies

Autor: White, A.L., Chan, H.T.C., French, R.R., Willoughby, J., Mockridge, C.I., Roghanian, A., Penfold, C.A., Booth, S.G., Dodhy, A., Polak, M.E., Potter, E.A., Ardern-Jones, M.R., Verbeek, J.S., Johnson, P.W.M., Al-Shamkhani, A., Cragg, M.S., Beers, S.A., Glennie, M.J.

Publikováno v: Cancer Cell, 27(1), 138-148

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::d5ef287e1a1c040f3be44fc069ce6807
http://hdl.handle.net/1887/105648

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Enhanced Fc alpha RI-mediated neutrophil migration towards tumour colonies in the presence of endothelial cells

Autor: Otten, MA, Bakema, J.E., Tuk, C.W., Glennie, M.J., Tutt, A.L., Beelen, R.H.J., Winkel, J.G.J., van Egmond, M.

Publikováno v: Otten, MA, Bakema, J E, Tuk, C W, Glennie, M J, Tutt, A L, Beelen, R H J, Winkel, J G J & van Egmond, M 2012, ' Enhanced Fc alpha RI-mediated neutrophil migration towards tumour colonies in the presence of endothelial cells ', European Journal of Immunology, vol. 42, no. 7, pp. 1815-1821 . https://doi.org/10.1002/eji.201141982
European Journal of Immunology, 42(7), 1815-1821. Wiley-VCH Verlag

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::ad37987a9a50a230b5077a430ec4a6a5
https://research.vumc.nl/en/publications/b7c58b63-7989-4341-a60a-d071c5af73b2