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Akademický článek

Impaired GK-GKRP interaction rather than direct GK activation worsens lipid profiles and contributes to long-term complications: a Mendelian randomization study.

Autor: Wang, Ke^1,2 (AUTHOR), Shi, Mai^1,3 (AUTHOR), Luk, Andrea O. Y.^1,3,4,5 (AUTHOR), Kong, Alice P. S.^1,3,4 (AUTHOR), Ma, Ronald C. W.^1,3,4 (AUTHOR), Li, Changhong² (AUTHOR), Chen, Li² (AUTHOR), Chow, Elaine^1,3,5 (AUTHOR) e.chow@cuhk.edu.hk, Chan, Juliana C. N.^1,3,4 (AUTHOR) jchan@cuhk.edu.hk

Publikováno v: Cardiovascular Diabetology. 6/29/2024, Vol. 23 Issue 1, p1-11. 11p.

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Akademický článek

Impaired GK-GKRP interaction rather than direct GK activation worsens lipid profiles and contributes to long-term complications: a Mendelian randomization study

Autor: Ke Wang, Mai Shi, Andrea O. Y. Luk, Alice P. S. Kong, Ronald C. W. Ma, Changhong Li, Li Chen, Elaine Chow, Juliana C. N. Chan

Publikováno v: Cardiovascular Diabetology, Vol 23, Iss 1, Pp 1-11 (2024)

Abstract Background Glucokinase (GK) plays a key role in glucose metabolism. In the liver, GK is regulated by GK regulatory protein (GKRP) with nuclear sequestration at low plasma glucose level. Some GK activators (GKAs) disrupt GK-GKRP interaction w

Externí odkaz: https://doaj.org/article/ab74b99469fc4c329a175d4f6db6e49d

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Akademický článek

Molecular insights into the inhibitory potential of anthocyanidins on glucokinase regulatory protein.

Autor: Kenneth, Christian¹ (AUTHOR), Anugrah, Daru Seto Bagus¹ (AUTHOR) daru.seto@atmajaya.ac.id, Julianus, Jeffry² (AUTHOR), Junedi, Sendy³ (AUTHOR)

Publikováno v: PLoS ONE. 7/19/2023, Vol. 18 Issue 7, p1-17. 17p.

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When a Little Bit More Makes the Difference: Expression Levels of GKRP Determines the Subcellular Localization of GK in Tanycytes

Autor: Magdiel Salgado, Patricio Ordenes, Marcos Villagra, Elena Uribe, María de los Angeles García-Robles, Estefanía Tarifeño-Saldivia

Publikováno v: Frontiers in Neuroscience, Vol 13 (2019)

Glucose homeostasis is performed by specialized cells types that detect and respond to changes in systemic glucose concentration. Hepatocytes, β-cells and hypothalamic tanycytes are part of the glucosensor cell types, which express several proteins

Externí odkaz: https://doaj.org/article/238bcbe0358940119fc79e9d71c1c642

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Akademický článek

Hepatic glucokinase regulatory protein and carbohydrate response element binding protein attenuation reduce de novo lipogenesis but do not mitigate intrahepatic triglyceride accumulation in Aldob deficiency

Autor: Amée M. Buziau, Maaike H. Oosterveer, Kristiaan Wouters, Trijnie Bos, Dean R. Tolan, Loranne Agius, Brian E. Ford, David Cassiman, Coen D.A. Stehouwer, Casper G. Schalkwijk, Martijn C.G.J. Brouwers

Publikováno v: Molecular Metabolism, Vol 87, Iss , Pp 101984- (2024)

Objective: Stable isotope studies have shown that hepatic de novo lipogenesis (DNL) plays an important role in the pathogenesis of intrahepatic lipid (IHL) deposition. Furthermore, previous research has demonstrated that fructose 1-phosphate (F1P) no

Externí odkaz: https://doaj.org/article/f788e7cbbd6b437a8180795a7483cdf6

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