Zobrazeno 1 - 10 of 42 pro vyhledávání: '"GK Singhera"'
1
Lipid nanoparticle formulations for optimal RNA-based topical delivery to murine airways
Autor: A Tam, J Kulkarni, K An, L Li, DR Dorscheid, GK Singhera, P Bernatchez, GSD Reid, KYT Chan, D Witzigmann, PR Cullis, DD Sin, CJ Lim
Publikováno v: European Journal of Pharmaceutical Sciences. 176:106234
Lipid nanoparticles (LNP) have been successfully used as a platform technology for delivering nucleic acids to the liver. To broaden the application of LNPs in targeting non-hepatic tissues, we developed LNP-based RNA therapies (siRNA or mRNA) for th
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::539cd56cf8b81e743f23246351a09222
https://doi.org/10.1016/j.ejps.2022.106234
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5
Akademický článek
TGFβ1, SMAD and β-catenin in pulmonary arteries of smokers, patients with small airway disease and COPD: potential drivers of EndMT.
Autor: Bhattarai P; Respiratory Translational Research Group, Department of Laboratory Medicine, School of Health Sciences, College of Health and Medicine, University of Tasmania, Launceston, Tasmania 7248, Australia., Lu W; Respiratory Translational Research Group, Department of Laboratory Medicine, School of Health Sciences, College of Health and Medicine, University of Tasmania, Launceston, Tasmania 7248, Australia., Hardikar A; Department of Cardiothoracic Surgery, Royal Hobart Hospital, Hobart, Tasmania 7000, Australia.; Department of Cardiothoracic Surgery, The Royal Adelaide Hospital, Adelaide South Australia, 5000 Australia., Gaikwad AV; Respiratory Translational Research Group, Department of Laboratory Medicine, School of Health Sciences, College of Health and Medicine, University of Tasmania, Launceston, Tasmania 7248, Australia., Dey S; Respiratory Translational Research Group, Department of Laboratory Medicine, School of Health Sciences, College of Health and Medicine, University of Tasmania, Launceston, Tasmania 7248, Australia., Shahzad AM; Respiratory Translational Research Group, Department of Laboratory Medicine, School of Health Sciences, College of Health and Medicine, University of Tasmania, Launceston, Tasmania 7248, Australia., Myers S; Respiratory Translational Research Group, Department of Laboratory Medicine, School of Health Sciences, College of Health and Medicine, University of Tasmania, Launceston, Tasmania 7248, Australia., Williams A; Respiratory Translational Research Group, Department of Laboratory Medicine, School of Health Sciences, College of Health and Medicine, University of Tasmania, Launceston, Tasmania 7248, Australia., Sutherland D; Department of Anaesthesiology, Pharmacology and Therapeutics, University of British Columbia, Vancouver, BC, Canada.; Centre for Heart Lung Innovation, St. Paul's Hospital, Vancouver, BC, Canada., Singhera GK; Department of Anaesthesiology, Pharmacology and Therapeutics, University of British Columbia, Vancouver, BC, Canada.; Centre for Heart Lung Innovation, St. Paul's Hospital, Vancouver, BC, Canada., Hackett TL; Department of Anaesthesiology, Pharmacology and Therapeutics, University of British Columbia, Vancouver, BC, Canada.; Centre for Heart Lung Innovation, St. Paul's Hospital, Vancouver, BC, Canada., Eapen MS; Respiratory Translational Research Group, Department of Laboratory Medicine, School of Health Sciences, College of Health and Medicine, University of Tasmania, Launceston, Tasmania 7248, Australia., Sohal SS; Respiratory Translational Research Group, Department of Laboratory Medicine, School of Health Sciences, College of Health and Medicine, University of Tasmania, Launceston, Tasmania 7248, Australia.
Publikováno v: Clinical science (London, England : 1979) [Clin Sci (Lond)] 2024 Sep 04; Vol. 138 (17), pp. 1055-1070.
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6
Akademický článek
Platelet Activating Factor Receptor and Intercellular Adhesion Molecule-1 Expression Increases in the Small Airway Epithelium and Parenchyma of Patients with Idiopathic Pulmonary Fibrosis: Implications for Microbial Pathogenesis.
Autor: Shahzad AM; Respiratory Translational Research Group, Department of Laboratory Medicine, School of Health Sciences, College of Health and Medicine, University of Tasmania, Launceston, TAS 7248, Australia.; Medical School, Oceania University of Medicine, Apia WS1330, Samoa., Lu W; Respiratory Translational Research Group, Department of Laboratory Medicine, School of Health Sciences, College of Health and Medicine, University of Tasmania, Launceston, TAS 7248, Australia.; National Health and Medical Research Council (NHMRC) Centre of Research Excellence (CRE) in Pulmonary Fibrosis, Respiratory Medicine and Sleep Unit, Royal Prince Alfred Hospital, Camperdown, NSW 2050, Australia., Dey S; Respiratory Translational Research Group, Department of Laboratory Medicine, School of Health Sciences, College of Health and Medicine, University of Tasmania, Launceston, TAS 7248, Australia., Bhattarai P; Respiratory Translational Research Group, Department of Laboratory Medicine, School of Health Sciences, College of Health and Medicine, University of Tasmania, Launceston, TAS 7248, Australia., Gaikwad AV; Respiratory Translational Research Group, Department of Laboratory Medicine, School of Health Sciences, College of Health and Medicine, University of Tasmania, Launceston, TAS 7248, Australia.; National Health and Medical Research Council (NHMRC) Centre of Research Excellence (CRE) in Pulmonary Fibrosis, Respiratory Medicine and Sleep Unit, Royal Prince Alfred Hospital, Camperdown, NSW 2050, Australia., Jaffar J; Department of Allergy, Immunology and Respiratory Medicine, The Alfred Hospital, Melbourne, VIC 3004, Australia.; Department of Immunology and Pathology, Monash University, Melbourne, VIC 3800, Australia., Westall G; Department of Allergy, Immunology and Respiratory Medicine, The Alfred Hospital, Melbourne, VIC 3004, Australia.; Department of Immunology and Pathology, Monash University, Melbourne, VIC 3800, Australia., Sutherland D; Department of Anaesthesiology, Pharmacology and Therapeutics, University of British Columbia, Vancouver, BC V6T 1Z4, Canada.; Centre for Heart Lung Innovation, St. Paul's Hospital, Vancouver, BC V6Z 1Y6, Canada., Singhera GK; Department of Anaesthesiology, Pharmacology and Therapeutics, University of British Columbia, Vancouver, BC V6T 1Z4, Canada.; Centre for Heart Lung Innovation, St. Paul's Hospital, Vancouver, BC V6Z 1Y6, Canada., Hackett TL; Department of Anaesthesiology, Pharmacology and Therapeutics, University of British Columbia, Vancouver, BC V6T 1Z4, Canada.; Centre for Heart Lung Innovation, St. Paul's Hospital, Vancouver, BC V6Z 1Y6, Canada., Eapen MS; Respiratory Translational Research Group, Department of Laboratory Medicine, School of Health Sciences, College of Health and Medicine, University of Tasmania, Launceston, TAS 7248, Australia.; National Health and Medical Research Council (NHMRC) Centre of Research Excellence (CRE) in Pulmonary Fibrosis, Respiratory Medicine and Sleep Unit, Royal Prince Alfred Hospital, Camperdown, NSW 2050, Australia., Sohal SS; Respiratory Translational Research Group, Department of Laboratory Medicine, School of Health Sciences, College of Health and Medicine, University of Tasmania, Launceston, TAS 7248, Australia.; National Health and Medical Research Council (NHMRC) Centre of Research Excellence (CRE) in Pulmonary Fibrosis, Respiratory Medicine and Sleep Unit, Royal Prince Alfred Hospital, Camperdown, NSW 2050, Australia.
Publikováno v: Journal of clinical medicine [J Clin Med] 2024 Apr 06; Vol. 13 (7). Date of Electronic Publication: 2024 Apr 06.
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7
Akademický článek
Differential expression of mast cells in the small airways and alveolar septa of current smokers and patients with small airway disease and COPD.
Autor: Eapen MS; Respiratory Translational Research Group, Department of Laboratory Medicine, School of Health Sciences, College of Health and Medicine, University of Tasmania, Launceston, Australia., Lu W; Respiratory Translational Research Group, Department of Laboratory Medicine, School of Health Sciences, College of Health and Medicine, University of Tasmania, Launceston, Australia.; Launceston Respiratory and Sleep Centre, Launceston, Australia., Dey S; Respiratory Translational Research Group, Department of Laboratory Medicine, School of Health Sciences, College of Health and Medicine, University of Tasmania, Launceston, Australia., Chia C; Respiratory Translational Research Group, Department of Laboratory Medicine, School of Health Sciences, College of Health and Medicine, University of Tasmania, Launceston, Australia.; Launceston Respiratory and Sleep Centre, Launceston, Australia.; Department of Respiratory Medicine, Launceston General Hospital, Launceston, Australia., Hardikar A; Department of Cardiothoracic Surgery, Royal Hobart Hospital, Hobart, Australia., Hassan MI; Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, New Delhi, India., Bhattarai P; Respiratory Translational Research Group, Department of Laboratory Medicine, School of Health Sciences, College of Health and Medicine, University of Tasmania, Launceston, Australia., Gaikwad AV; Respiratory Translational Research Group, Department of Laboratory Medicine, School of Health Sciences, College of Health and Medicine, University of Tasmania, Launceston, Australia., Das S; Faculty of Science, Centre for Inflammation, Centenary Institute and University of Technology Sydney School of Life Sciences, Sydney, Australia., Hansbro PM; Faculty of Science, Centre for Inflammation, Centenary Institute and University of Technology Sydney School of Life Sciences, Sydney, Australia., Singhera GK; Department of Anaesthesiology, Pharmacology and Therapeutics, University of British Columbia, Vancouver, BC, Canada.; Centre for Heart Lung Innovation, St Paul's Hospital, Vancouver, BC, Canada., Hackett TL; Department of Anaesthesiology, Pharmacology and Therapeutics, University of British Columbia, Vancouver, BC, Canada.; Centre for Heart Lung Innovation, St Paul's Hospital, Vancouver, BC, Canada., Sohal SS; Respiratory Translational Research Group, Department of Laboratory Medicine, School of Health Sciences, College of Health and Medicine, University of Tasmania, Launceston, Australia.; Launceston Respiratory and Sleep Centre, Launceston, Australia.
Publikováno v: ERJ open research [ERJ Open Res] 2024 Mar 18; Vol. 10 (2). Date of Electronic Publication: 2024 Mar 18 (Print Publication: 2024).
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8
Akademický článek
TGF-β1, pSmad-2/3, Smad-7, and β-Catenin Are Augmented in the Pulmonary Arteries from Patients with Idiopathic Pulmonary Fibrosis (IPF): Role in Driving Endothelial-to-Mesenchymal Transition (EndMT).
Autor: Gaikwad AV; Respiratory Translational Research Group, Department of Laboratory Medicine, School of Health Sciences, College of Health and Medicine, University of Tasmania, Launceston, TAS 7248, Australia.; National Health and Medical Research Council (NHMRC) Centre of Research Excellence (CRE) in Pulmonary Fibrosis, Respiratory Medicine and Sleep Unit, Royal Prince Alfred Hospital, Camperdown, NSW 2050, Australia., Eapen MS; Respiratory Translational Research Group, Department of Laboratory Medicine, School of Health Sciences, College of Health and Medicine, University of Tasmania, Launceston, TAS 7248, Australia.; National Health and Medical Research Council (NHMRC) Centre of Research Excellence (CRE) in Pulmonary Fibrosis, Respiratory Medicine and Sleep Unit, Royal Prince Alfred Hospital, Camperdown, NSW 2050, Australia., Dey S; Respiratory Translational Research Group, Department of Laboratory Medicine, School of Health Sciences, College of Health and Medicine, University of Tasmania, Launceston, TAS 7248, Australia., Bhattarai P; Respiratory Translational Research Group, Department of Laboratory Medicine, School of Health Sciences, College of Health and Medicine, University of Tasmania, Launceston, TAS 7248, Australia., Shahzad AM; Respiratory Translational Research Group, Department of Laboratory Medicine, School of Health Sciences, College of Health and Medicine, University of Tasmania, Launceston, TAS 7248, Australia., Chia C; Respiratory Translational Research Group, Department of Laboratory Medicine, School of Health Sciences, College of Health and Medicine, University of Tasmania, Launceston, TAS 7248, Australia.; Launceston Respiratory and Sleep Centre, Launceston, TAS 7250, Australia.; Department of Respiratory Medicine, Launceston General Hospital, Launceston, TAS 7250, Australia., Jaffar J; Department of Allergy, Immunology and Respiratory Medicine, The Alfred Hospital, Melbourne, VIC 3004, Australia.; Department of Immunology and Pathology, Monash University, Melbourne, VIC 3004, Australia., Westall G; Department of Allergy, Immunology and Respiratory Medicine, The Alfred Hospital, Melbourne, VIC 3004, Australia.; Department of Immunology and Pathology, Monash University, Melbourne, VIC 3004, Australia., Sutherland D; Department of Anaesthesiology, Pharmacology and Therapeutics, University of British Columbia, Vancouver, BC V6T 1Z4, Canada.; Centre for Heart Lung Innovation, St. Paul's Hospital, Vancouver, BC V6Z 1Y6, Canada., Singhera GK; Department of Anaesthesiology, Pharmacology and Therapeutics, University of British Columbia, Vancouver, BC V6T 1Z4, Canada.; Centre for Heart Lung Innovation, St. Paul's Hospital, Vancouver, BC V6Z 1Y6, Canada., Hackett TL; Department of Anaesthesiology, Pharmacology and Therapeutics, University of British Columbia, Vancouver, BC V6T 1Z4, Canada.; Centre for Heart Lung Innovation, St. Paul's Hospital, Vancouver, BC V6Z 1Y6, Canada., Lu W; Respiratory Translational Research Group, Department of Laboratory Medicine, School of Health Sciences, College of Health and Medicine, University of Tasmania, Launceston, TAS 7248, Australia.; National Health and Medical Research Council (NHMRC) Centre of Research Excellence (CRE) in Pulmonary Fibrosis, Respiratory Medicine and Sleep Unit, Royal Prince Alfred Hospital, Camperdown, NSW 2050, Australia.; Launceston Respiratory and Sleep Centre, Launceston, TAS 7250, Australia., Sohal SS; Respiratory Translational Research Group, Department of Laboratory Medicine, School of Health Sciences, College of Health and Medicine, University of Tasmania, Launceston, TAS 7248, Australia.; National Health and Medical Research Council (NHMRC) Centre of Research Excellence (CRE) in Pulmonary Fibrosis, Respiratory Medicine and Sleep Unit, Royal Prince Alfred Hospital, Camperdown, NSW 2050, Australia.; Launceston Respiratory and Sleep Centre, Launceston, TAS 7250, Australia.
Publikováno v: Journal of clinical medicine [J Clin Med] 2024 Feb 19; Vol. 13 (4). Date of Electronic Publication: 2024 Feb 19.
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9
Akademický článek
Endothelial to mesenchymal transition is an active process in smokers and patients with early COPD contributing to pulmonary arterial pathology.
Autor: Bhattarai P; Respiratory Translational Research Group, Department of Laboratory Medicine, School of Health Sciences, College of Health and Medicine, University of Tasmania, Launceston, TAS, Australia.; Launceston Respiratory and Sleep Centre, Launceston, TAS, Australia., Lu W; Respiratory Translational Research Group, Department of Laboratory Medicine, School of Health Sciences, College of Health and Medicine, University of Tasmania, Launceston, TAS, Australia.; Launceston Respiratory and Sleep Centre, Launceston, TAS, Australia., Hardikar A; Department of Cardiothoracic Surgery, Royal Hobart Hospital, Hobart, TAS, Australia.; Department of Cardiothoracic Surgery, The Royal Adelaide Hospital, Adelaide, SA, Australia., Dey S; Respiratory Translational Research Group, Department of Laboratory Medicine, School of Health Sciences, College of Health and Medicine, University of Tasmania, Launceston, TAS, Australia., Gaikwad AV; Respiratory Translational Research Group, Department of Laboratory Medicine, School of Health Sciences, College of Health and Medicine, University of Tasmania, Launceston, TAS, Australia., Shahzad AM; Respiratory Translational Research Group, Department of Laboratory Medicine, School of Health Sciences, College of Health and Medicine, University of Tasmania, Launceston, TAS, Australia., Chia C; Respiratory Translational Research Group, Department of Laboratory Medicine, School of Health Sciences, College of Health and Medicine, University of Tasmania, Launceston, TAS, Australia.; Launceston Respiratory and Sleep Centre, Launceston, TAS, Australia.; Department of Respiratory Medicine, Launceston General Hospital, Launceston, TAS, Australia., Williams A; Respiratory Translational Research Group, Department of Laboratory Medicine, School of Health Sciences, College of Health and Medicine, University of Tasmania, Launceston, TAS, Australia., Singhera GK; Department of Anaesthesiology, Pharmacology and Therapeutics, University of British Columbia, Vancouver, BC, Canada.; Centre for Heart Lung Innovation, St Paul's Hospital, Vancouver, BC, Canada., Hackett TL; Department of Anaesthesiology, Pharmacology and Therapeutics, University of British Columbia, Vancouver, BC, Canada.; Centre for Heart Lung Innovation, St Paul's Hospital, Vancouver, BC, Canada., Eapen MS; Respiratory Translational Research Group, Department of Laboratory Medicine, School of Health Sciences, College of Health and Medicine, University of Tasmania, Launceston, TAS, Australia., Sohal SS; Respiratory Translational Research Group, Department of Laboratory Medicine, School of Health Sciences, College of Health and Medicine, University of Tasmania, Launceston, TAS, Australia.; Launceston Respiratory and Sleep Centre, Launceston, TAS, Australia.
Publikováno v: ERJ open research [ERJ Open Res] 2024 Feb 12; Vol. 10 (1). Date of Electronic Publication: 2024 Feb 12 (Print Publication: 2024).
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10
Akademický článek
Epithelial-mesenchymal transition changes in nonsmall cell lung cancer patients with early COPD.
Autor: Lu W; Respiratory Translational Research Group, School of Health Sciences, University of Tasmania, Newnham, TAS, Australia.; Launceston Respiratory and Sleep Centre, Launceston, TAS, Australia., Eapen MS; Respiratory Translational Research Group, School of Health Sciences, University of Tasmania, Newnham, TAS, Australia., Hardikar A; Department of Cardiothoracic Surgery, Royal Hobart Hospital, Hobart, TAS, Australia., Chia C; Respiratory Translational Research Group, School of Health Sciences, University of Tasmania, Newnham, TAS, Australia.; Launceston Respiratory and Sleep Centre, Launceston, TAS, Australia.; Department of Respiratory Medicine, Launceston General Hospital, Launceston, TAS, Australia., Robertson I; Respiratory Translational Research Group, School of Health Sciences, University of Tasmania, Newnham, TAS, Australia., Singhera GK; Department of Anesthesiology, Pharmacology and Therapeutics, Department of Medicine, University of British Columbia, Vancouver, BC, Canada.; UBC Centre for Heart Lung Innovation, St Paul's Hospital, Vancouver, BC, Canada., Hackett TL; Department of Anesthesiology, Pharmacology and Therapeutics, Department of Medicine, University of British Columbia, Vancouver, BC, Canada.; UBC Centre for Heart Lung Innovation, St Paul's Hospital, Vancouver, BC, Canada., Sohal SS; Respiratory Translational Research Group, School of Health Sciences, University of Tasmania, Newnham, TAS, Australia.; Launceston Respiratory and Sleep Centre, Launceston, TAS, Australia.
Publikováno v: ERJ open research [ERJ Open Res] 2023 Dec 27; Vol. 9 (6). Date of Electronic Publication: 2023 Dec 27 (Print Publication: 2023).
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