Inhibitors of sterol synthesis. Chemical synthesis and spectral properties of 3 beta-hydroxy-5 alpha-cholesta-8(14),24-dien-15-one, 3 beta,25-dihydroxy-5 alpha-cholest-8(14)-en-15-one, and 3 beta,24-dihydroxy-5 alpha-cholest-8(14)-en-15-one and their effects on 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in CHO-K1 cells.

Autor: S Swaminathan, FD Pinkerton, S Numazawa, WK Wilson, GJ Schroepfer, Jr

Publikováno v: Journal of Lipid Research, Vol 33, Iss 10, Pp 1503-1515 (1992)

Side-chain functionalized delta 8(14)-15-ketosterols have been synthesized from 3 beta-acetoxy-24-hydroxy-5 alpha-chol-8(14)-en-15-one (VI) as part of a program to prepare potential metabolites and analogs of 3 beta-hydroxy-5 alpha-cholest-8(14)-en-1

Externí odkaz: https://doaj.org/article/64b7b232f2864ed493edd8a8a1cbf54e

Inhibitors of sterol synthesis. Characterization of beta,gamma-unsaturated analogs of 3 beta-hydroxy-5 alpha-cholest-8(14)-en-15-one and their effects on 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in CHO-K1 cells.

Autor: WK Wilson, ME Wheeler, FD Pinkerton, J St Pyrek, GJ Schroepfer, Jr

Publikováno v: Journal of Lipid Research, Vol 32, Iss 7, Pp 1215-1227 (1991)

Treatment of 3 beta-hydroxy-5 alpha-cholest-8(14)-en-15-one (1), a potent regulator of cholesterol metabolism, with perchloric acid in methanol resulted in its partial isomerization to the beta,gamma-unsaturated 15-ketosterols, 3 beta-hydroxy-5 alpha

Externí odkaz: https://doaj.org/article/f956d957ab3b4322b392abad85a32400

Alternative pathways of sterol synthesis in yeast. Use of C(27) sterol tracers to study aberrant double-bond migrations and evaluate their relative importance.

Autor: Ruan B; Department of Chemistry, Rice University, 6100 Main Street, Houston, TX 77005, USA., Lai PS, Yeh CW, Wilson WK, Pang J, Xu R, Matsuda SP, Schroepfer GJ Jr

Publikováno v: Steroids [Steroids] 2002 Dec; Vol. 67 (13-14), pp. 1109-19.

Progestins block cholesterol synthesis to produce meiosis-activating sterols.

Autor: Lindenthal B; Department of Physiology and Experimental Medicine, The George Washington University School of Medical and Health Sciences, Washington, DC 20037, USA. bernard.lindenthal@schering.de, Holleran AL, Aldaghlas TA, Ruan B, Schroepfer GJ Jr, Wilson WK, Kelleher JK

Publikováno v: FASEB journal : official publication of the Federation of American Societies for Experimental Biology [FASEB J] 2001 Mar; Vol. 15 (3), pp. 775-84.

Aberrant pathways in the late stages of cholesterol biosynthesis in the rat. Origin and metabolic fate of unsaturated sterols relevant to the Smith-Lemli-Opitz syndrome.

Autor: Ruan B; Department of Biochemistry and Cell Biology, Rice University, Houston, TX 77005, USA., Tsai J, Wilson WK, Schroepfer GJ Jr

Publikováno v: Journal of lipid research [J Lipid Res] 2000 Nov; Vol. 41 (11), pp. 1772-82.