Zobrazeno 1 - 10
of 215
pro vyhledávání: '"GJ Lindeman"'
Autor:
Maria Joao Silva, Mark Rosenthal, Alice Ruth Bergin, Andrew W. Roberts, Daniel H.D. Gray, GB Mann, D Liew, Jayesh Desai, Kylie Shackleton, Anand Murugasu, GJ Lindeman, Sheau Wen Lok, François Vaillant, James R. Whittle, S-J Dawson, C Teh, Avraham Travers, Peter Sherman, Zhen Rong Siow, JE Visvader
Publikováno v:
Cancer Research. 79:PD1-06
Background: Venetoclax, a potent and selective inhibitor of the survival protein BCL-2 (recently approved in CLL and in development in other hematopoietic malignancies), has yet to be evaluated in pts with solid tumors. BCL-2 is overexpressed in ˜85
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f738bf48a694e10673dd548ea87a4c03
https://doi.org/10.1158/1538-7445.sabcs18-pd1-06
https://doi.org/10.1158/1538-7445.sabcs18-pd1-06
Autor:
N Lalaoui, Merino, Delphine, G Giner, F Vaillant, D Chau, L Liu, T Kratina, Pal, Bhupinder, JR Whittle, Etemadi, Nima, Berthelet, Jean, J Gräsel, C Hall, ME Ritchie, Ernst, Matthias, GK Smyth, Vaux, David, JE Visvader, GJ Lindeman, Silke, John
© 2020, The Author(s), under exclusive licence to ADMC Associazione Differenziamento e Morte Cellulare. Smac mimetics target inhibitor of apoptosis (IAP) proteins, thereby suppressing their function to facilitate tumor cell death. Here we have evalu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ecf501fb6b8f40ba466b0d0b8ffb3017
Autor:
Bhupinder Pal, Gordon K. Smyth, JE Visvader, François Vaillant, Sheau Wen Lok, Göknur Giner, Emma Nolan, Kylie Shackleton, Lachlan Whitehead, GB Mann, GJ Lindeman
Publikováno v:
Cancer Research. 76:P3-11
Background: BRCA1 mutation carriers often undergo prophylactic mastectomy to minimize their risk of breast cancer. The value of targeting ovarian hormones to prevent breast tumorigenesis remains contentious and the identification of an effective and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0d019c830616be34fa21c9fe7be772a4
https://doi.org/10.1158/1538-7445.sabcs15-p3-11-05
https://doi.org/10.1158/1538-7445.sabcs15-p3-11-05
Autor:
GJ Lindeman, E Nolan, F Vaillant, D Branstetter, B Pal, G Giner, L Whitehead, SW Lok, GB Mann, Consortium kConFab, K Rohrbach, L-Y Huang, R Soriano, GK Smyth, WC Dougall, JE Visvader
Publikováno v:
Cancer Research. 77:S2-04
Background: BRCA1 mutation carriers commonly undergo prophylactic mastectomy to reduce their risk of breast cancer. The precise role of chemoprevention with tamoxifen, which reduces the incidence of ER-positive breast cancer in the general population
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a7dafe740bd136e7819c384791afae36
https://doi.org/10.1158/1538-7445.sabcs16-s2-04
https://doi.org/10.1158/1538-7445.sabcs16-s2-04
Autor:
Jaring Schreuder, L Di Stefano, Yunshun Chen, Kevin H. Liu, Tom S. Weber, Jane E. Visvader, M-L Asselin-Labat, Bhupinder Pal, Anthony T. Papenfuss, François Vaillant, Dawn S. Lin, Daniel L Cameron, Antonin Serrano, Shalin H. Naik, Delphine Merino, Gordon K. Smyth, GJ Lindeman, Ton N. Schumacher
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-2 (2019)
Nature Communications
Nature Communications
Primary triple negative breast cancers (TNBC) are prone to dissemination but sub-clonal relationships between tumors and resulting metastases are poorly understood. Here we use cellular barcoding of two treatment-naïve TNBC patient-derived xenograft
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9974486c62ee2fa78f91e5d68628ba50
http://link.springer.com/article/10.1038/s41467-019-09916-1
http://link.springer.com/article/10.1038/s41467-019-09916-1
Autor:
Daniel H.D. Gray, Kevin H. Liu, GJ Lindeman, François Vaillant, Bhupinder Pal, Antonia N. Policheni, James R. Whittle, JE Visvader, Gordon K. Smyth, CE Caldon, Göknur Giner, K Fernandez
Publikováno v:
Cancer Research. 79:PD7-07
Background: Despite incremental advances in chemotherapy and endocrine therapy, survival outcomes for patients with ER-positive (ER+) metastatic breast cancer (MBC) remain poor. The majority of relapsing tumors exhibit deregulation of the cyclin-depe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b627c3f8598ab3b41e723a3f69f815b0
https://doi.org/10.1158/1538-7445.sabcs18-pd7-07
https://doi.org/10.1158/1538-7445.sabcs18-pd7-07
Autor:
Louisa J. Phillipson, Matthew E. Ritchie, Lily Lee, Bhupinder Pal, François Vaillant, Gordon K. Smyth, GB Mann, Delphine Merino, Christopher J. Burns, JE Visvader, GJ Lindeman, Michael Christie, Kelsey Breslin
Publikováno v:
Cancer Research. 73:P2-09
Background: Impairment of apoptosis is a hallmark of cancer and can result in resistance to therapy. Over-expression of the pro-survival protein BCL-2 is common in breast cancer, with elevated levels found in approximately 85% of luminal tumors. Alth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::151ef2e1c7d0079e86c2356f3071401b
https://doi.org/10.1158/0008-5472.sabcs13-p2-09-01
https://doi.org/10.1158/0008-5472.sabcs13-p2-09-01
Autor:
Samantha R. Oakes, Heidi N. Hilton, Lewis A. Chodosh, Melanie April Pritchard, Marie Liesse Asselin-Labat, Margaret Gardiner-Garden, Katrina Blazek, GJ Lindeman, Michael Kazlauskas, Matthew J. Naylor, Jane E. Visvader, Christopher J. Ormandy, Peter L. Pfeffer
Publikováno v:
Genes & Development. 22:581-586
Hormonal cues regulate mammary development, but the consequent transcriptional changes and cell fate decisions are largely undefined. We show that knockout of the prolactin-regulated Ets transcription factor Elf5 prevented formation of the secretory
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::775b435bc6f70b54e03c36b1b4e25f09
https://doi.org/10.1101/gad.1614608
https://doi.org/10.1101/gad.1614608
Autor:
Matthew E. Ritchie, GJ Lindeman, Tamara Beck, Julie Sheridan, Jane E. Visvader, François Vaillant, Gordon K. Smyth, Sarah A. Best, Kenneth Liu, Kun Jiang, Ross A. Dickins
Publikováno v:
BMC Cancer
Background The molecular regulators that orchestrate stem cell renewal, proliferation and differentiation along the mammary epithelial hierarchy remain poorly understood. Here we have performed a large-scale pooled RNAi screen in primary mouse mammar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7fd5e0fa730e545459aedc0d3937dc5
http://europepmc.org/articles/PMC4399223
http://europepmc.org/articles/PMC4399223
Autor:
Ross A. Dickins, Jane E. Visvader, Bhupinder Pal, Andreas Strasser, François Vaillant, Marie Liesse Asselin-Labat, Phillipe Bouillet, Delphine Merino, Sarah A. Best, Robin L. Anderson, GJ Lindeman
Publikováno v:
Oncogene. 34(30)
Evasion of cell death is fundamental to the development of cancer and its metastasis. The role of the BCL-2-mediated (intrinsic) apoptotic program in these processes remains poorly understood. Here we have investigated the relevance of the pro-apopto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c1f68d534d0d4a244a3f8a774424b92
https://pubmed.ncbi.nlm.nih.gov/25263453
https://pubmed.ncbi.nlm.nih.gov/25263453