Zobrazeno 1 - 10 of 42 pro vyhledávání: '"GJ Durant"'
1
Isocytosine H2-receptor histamine antagonists. IV. The synthesis and biological activity of donetidine (SK&F 93574) and related compounds
Autor: Ganellin Ch R, A. C. Rasmussen, Michael E. Parsons, T. H. Brown, DA Rawlings, GJ Durant, R. C. Blakemore
Publikováno v: European Journal of Medicinal Chemistry. 28:601-608
The synthesis and biological activity of some novel 2-amino-4-pyrimidone derivatives is described. Side-chains associated with H 2 -antagonist activity are attached through the 2-amino group, whilst a range of 2-hydroxypyridine containing moieties ar
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::48dc144e3e704993541fddbdafd8afb3
https://doi.org/10.1016/0223-5234(93)90091-r
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2
Akademický článek
The pharmacology of cimetidine, a new histamine H2-receptor antagonist. 1975.
Autor: Brimblecombe RW, Duncan WA, Durant GJ, Ganellin CR, Parsons ME, Black JW
Publikováno v: British journal of pharmacology [Br J Pharmacol] 2010 Jul; Vol. 160 Suppl 1, pp. S52-3.
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3
Akademický článek
Solution-phase, parallel synthesis and pharmacological evaluation of acylguanidine derivatives as potential sodium channel blockers.
Autor: Padmanabhan S; CeNeS Pharmaceuticals Inc., 333 Providence Highway, Norwood, MA 02062, USA. padman12@hotmail.com, Lavin RC, Thakker PM, Guo J, Zhang L, Moore D, Perlman ME, Kirk C, Daly D, Burke-Howie KJ, Wolcott T, Chari S, Berlove D, Fischer JB, Holt WF, Durant GJ, McBurney RN
Publikováno v: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2001 Dec 17; Vol. 11 (24), pp. 3151-5.
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4
Akademický článek
Identification and characterization of a potential ischemia-selective N-methyl-D-aspartate (NMDA) receptor ion-channel blocker, CNS 5788.
Autor: Padmanabhan S; Cambridge NeuroScience, Inc., Norwood, MA 02602, USA. padman@cambneuro.com, Perlman ME, Zhang L, Moore D, Zhou D, Fischer JB, Durant GJ, McBurney RN
Publikováno v: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2001 Feb 26; Vol. 11 (4), pp. 501-4.
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5
Akademický článek
Synthesis and binding characteristics of N-(1-naphthyl)-N'-(3-[(125)I]-iodophenyl)-N'-methylguanidine ([(125)I]-CNS 1261): a potential SPECT agent for imaging NMDA receptor activation.
Autor: Owens J; Department of Clinical Physics, University of Glasgow, Glasgow, UK. j.owens@clinmed.gla.ac.uk, Tebbutt AA, McGregor AL, Kodama K, Magar SS, Perlman ME, Robins DJ, Durant GJ, McCulloch J
Publikováno v: Nuclear medicine and biology [Nucl Med Biol] 2000 Aug; Vol. 27 (6), pp. 557-64.
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6
Akademický článek
Synthesis and pharmacological evaluation of N,N'-diarylguanidines as potent sodium channel blockers and anticonvulsant agents.
Autor: Reddy NL; Cambridge NeuroScience, Inc., Cambridge, Massachusetts 02139, USA. lreddy@pharmeco.com, Fan W, Magar SS, Perlman ME, Yost E, Zhang L, Berlove D, Fischer JB, Burke-Howie K, Wolcott T, Durant GJ
Publikováno v: Journal of medicinal chemistry [J Med Chem] 1998 Aug 13; Vol. 41 (17), pp. 3298-302.
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7
Akademický článek
Design, synthesis, and pharmacological evaluation of conformationally constrained analogues of N,N'-diaryl- and N-aryl-N-aralkylguanidines as potent inhibitors of neuronal Na+ channels.
Autor: Maillard MC; Cambridge NeuroScience Inc., One Kendall Square, Cambridge, Massachusetts 02139, USA., Perlman ME, Amitay O, Baxter D, Berlove D, Connaughton S, Fischer JB, Guo JQ, Hu LY, McBurney RN, Nagy PI, Subbarao K, Yost EA, Zhang L, Durant GJ
Publikováno v: Journal of medicinal chemistry [J Med Chem] 1998 Jul 30; Vol. 41 (16), pp. 3048-61.
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8
Akademický článek
Synthesis and pharmacological evaluation of N-(2,5-disubstituted phenyl)-N'-(3-substituted phenyl)-N'-methylguanidines as N-methyl-D-aspartate receptor ion-channel blockers.
Autor: Hu LY; Cambridge NeuroScience, Inc., Massachusetts 02139, USA., Guo J, Magar SS, Fischer JB, Burke-Howie KJ, Durant GJ
Publikováno v: Journal of medicinal chemistry [J Med Chem] 1997 Dec 19; Vol. 40 (26), pp. 4281-9.
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9
Akademický článek
Synthesis and biochemical activity of novel amidine derivatives as m1 muscarinic receptor agonists.
Autor: Ojo B; Department of Medicinal and Biological Chemistry, College of Pharmacy, University of Toledo, OH 43606, USA., Dunbar PG, Durant GJ, Nagy PI, Huzl JJ 3rd, Periyasamy S, Ngur DO, el-Assadi AA, Hoss WP, Messer WS Jr
Publikováno v: Bioorganic & medicinal chemistry [Bioorg Med Chem] 1996 Oct; Vol. 4 (10), pp. 1605-15.
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10
Akademický článek
Pharmacological characterization of GT-2016, a non-thiourea-containing histamine H3 receptor antagonist: in vitro and in vivo studies.
Autor: Tedford CE; Gliatech, Inc., Cleveland, Ohio, USA., Yates SL, Pawlowski GP, Nalwalk JW, Hough LB, Khan MA, Phillips JG, Durant GJ, Frederickson RC
Publikováno v: The Journal of pharmacology and experimental therapeutics [J Pharmacol Exp Ther] 1995 Nov; Vol. 275 (2), pp. 598-604.
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