Zobrazeno 1 - 10
of 114
pro vyhledávání: '"GIUSEPPE SACCOMANNI"'
Autor:
Rebecca Ferrisi, Francesca Gado, Beatrice Polini, Caterina Ricardi, Kawthar A. Mohamed, Lesley A. Stevenson, Gabriella Ortore, Simona Rapposelli, Giuseppe Saccomanni, Roger G. Pertwee, Robert B. Laprairie, Clementina Manera, Grazia Chiellini
Publikováno v:
Frontiers in Chemistry, Vol 10 (2022)
It is well known that G protein–coupled receptors (GPCRs) assume multiple active states. Orthosteric ligands and/or allosteric modulators can preferentially stabilize specific conformations, giving rise to pathway-biased signaling. One of the most
Externí odkaz:
https://doaj.org/article/2b848fee1ff74619863f32ed3419e73b
Autor:
Andrea Bacci, Francesca Corsi, Massimiliano Runfola, Simona Sestito, Ilaria Piano, Clementina Manera, Giuseppe Saccomanni, Claudia Gargini, Simona Rapposelli
Publikováno v:
Pharmaceuticals, Vol 15, Iss 6, p 688 (2022)
Overproduction of reactive oxygen species (ROS) and alterations in metallostasis are common and related hallmarks in several neurodegenerative diseases (NDDs). Nature-based derivatives always represent an attractive tool in MTDL drug design, especial
Externí odkaz:
https://doaj.org/article/01cccc83f1664f2b81c758eca66ebccf
Autor:
Francesca Gado, Rebecca Ferrisi, Sarah Di Somma, Fabiana Napolitano, Kawthar A. Mohamed, Lesley A. Stevenson, Simona Rapposelli, Giuseppe Saccomanni, Giuseppe Portella, Roger G. Pertwee, Robert B. Laprairie, Anna Maria Malfitano, Clementina Manera
Publikováno v:
Molecules, Vol 27, Iss 9, p 3019 (2022)
1,8-naphthyridine-3-carboxamide structures were previously identified as a promising scaffold from which to obtain CB2R agonists with anticancer and anti-inflammatory activity. This work describes the synthesis and functional characterization of new
Externí odkaz:
https://doaj.org/article/101b3cbd7b224d4aafd7636fae7db135
Autor:
Silvia Tampucci, Antonella Castagna, Daniela Monti, Clementina Manera, Giuseppe Saccomanni, Patrizia Chetoni, Erica Zucchetti, Mariacristina Barbagallo, Laura Fazio, Marco Santin, Annamaria Ranieri
Publikováno v:
Foods, Vol 10, Iss 2, p 335 (2021)
Chitosan is receiving increasing attention from the food industry for being a biodegradable, non-toxic, antimicrobial biopolymer able to extend the shelf life of, and preserve the quality of, fresh food. However, few studies have investigated the abi
Externí odkaz:
https://doaj.org/article/562c9a672b8546e68ab5a9a3ec8a9096
Autor:
Simone Bertini, Giuseppe Saccomanni, Sara Del Carlo, Maria Digiacomo, Claudia Gargini, Ilaria Piano, Giuseppe Matteo Campisi, Riccardo Ghidoni, Marco Macchia, Clementina Manera
Publikováno v:
Molecules, Vol 22, Iss 7, p 1198 (2017)
In this work, we reported the application and validation of an improved high-performance liquid chromatography method coupled with a fluorimetric detector (HPLC-FL) to screen the activity of two heterocyclic derivatives reported as serine palmitoyl t
Externí odkaz:
https://doaj.org/article/79f8bc55b504453ea155fddf5d2653e7
Autor:
Anna Maria Malfitano, Chiara Laezza, Alba D'Alessandro, Claudio Procaccini, Giuseppe Saccomanni, Tiziano Tuccinardi, Clementina Manera, Marco Macchia, Giuseppe Matarese, Patrizia Gazzerro, Maurizio Bifulco
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e62511 (2013)
The efficacy of cannabinoids in the treatment of multiple sclerosis is widely documented; however their use is limited by psychoactivity mainly ascribed to the activation of the cannabinoid receptor CB1. Emerging findings support as alternative strat
Externí odkaz:
https://doaj.org/article/98aa2cfd08b54f5dbc91607cb4c345be
Autor:
Rebecca Ferrisi, Beatrice Polini, Caterina Ricardi, Francesca Gado, Kawthar A. Mohamed, Giovanna Baron, Salvatore Faiella, Giulio Poli, Simona Rapposelli, Giuseppe Saccomanni, Giancarlo Aldini, Grazia Chiellini, Robert B. Laprairie, Clementina Manera, Gabriella Ortore
Publikováno v:
International Journal of Molecular Sciences
Volume 24
Issue 3
Pages: 2135
Volume 24
Issue 3
Pages: 2135
Very recently, we have developed a new generation of ligands targeting the cannabinoid receptor type 2 (CB2R), namely JR compounds, which combine the pharmacophoric portion of the CB2R positive allosteric modulator (PAM), EC21a, with that of the CB2R
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83f397d1143c24200c5c16a2b9b2028b
Autor:
Piero A. Salvadori, Valentina Lucchesi, Giuseppe Saccomanni, Giancarlo Pascali, Clementina Manera, Simone Zanoni, Elena Sanguinetti, Daniele Panetta, Silvia Burchielli, Mariarosaria De Simone, Patricia Iozzo
Publikováno v:
Australian Journal of Chemistry. 74:443-452
We successfully radiolabelled a novel prospective cannabinoid type 2 receptor ligand with 18F and tested its biodistribution in animal models by positron emission tomography (PET)/computed tomography (CT) imaging. The radiolabelling process was condu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d4ded4398d35ed73b3b82c948c0be3e1
https://doi.org/10.1071/ch20247
https://doi.org/10.1071/ch20247
Autor:
Francesca Gado, Rebecca Ferrisi, Beatrice Polini, Kawthar A. Mohamed, Caterina Ricardi, Elena Lucarini, Sara Carpi, Federica Domenichini, Lesley A. Stevenson, Simona Rapposelli, Giuseppe Saccomanni, Paola Nieri, Gabriella Ortore, Roger G. Pertwee, Carla Ghelardini, Lorenzo Di Cesare Mannelli, Grazia Chiellini, Robert B. Laprairie, Clementina Manera
The design of dualsteric/bitopic agents as single chemical entities able to simultaneously interact with both the orthosteric and an allosteric binding site represents a novel approach in medicinal chemistry. Biased dualsteric/bitopic agents could en
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29155d9071580356b8bd518eaa959c74
https://hdl.handle.net/2434/967377
https://hdl.handle.net/2434/967377
Autor:
Annamaria Ranieri, Erica Zucchetti, Marco Santin, Laura Fazio, Antonella Castagna, Mariacristina Barbagallo, Daniela Monti, Giuseppe Saccomanni, Patrizia Chetoni, Clementina Manera, Silvia Tampucci
Publikováno v:
Foods, Vol 10, Iss 335, p 335 (2021)
Foods
Volume 10
Issue 2
Foods
Volume 10
Issue 2
Chitosan is receiving increasing attention from the food industry for being a biodegradable, non-toxic, antimicrobial biopolymer able to extend the shelf life of, and preserve the quality of, fresh food. However, few studies have investigated the abi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e9b3cdcc7576c30c2a84743200a1f46
https://www.mdpi.com/2304-8158/10/2/335
https://www.mdpi.com/2304-8158/10/2/335