Zobrazeno 1 - 10
of 155
pro vyhledávání: '"GITRL"'
Publikováno v:
Biomolecules, Vol 14, Iss 3, p 294 (2024)
Eosinophilic asthma is the most prevalent and well-defined phenotype of asthma. Despite a majority of patients responding to corticosteroid therapy and T2 biologics, there remains a subset that have recurrent asthma exacerbations, highlighting a need
Externí odkaz:
https://doaj.org/article/b6eb6ef4a6c84e84ac0164ed15713474
Autor:
Yaping Wang, Kou Liao, Bo Liu, Chao Niu, Wenjing Zou, Lili Yang, Ting Wang, Daiyin Tian, Zhengxiu Luo, Jihong Dai, Qubei Li, Enmei Liu, Caihui Gong, Zhou Fu, Ying Li, Fengxia Ding
Publikováno v:
Respiratory Research, Vol 22, Iss 1, Pp 1-17 (2021)
Abstract Background Glucocorticoid-induced tumor necrosis factor receptor family-related protein ligand (GITRL) plays an important role in tumors, autoimmunity and inflammation. However, GITRL is not known to modulate the pathogenesis of allergic ast
Externí odkaz:
https://doaj.org/article/e8690cd181944223b75a28ff332f9cc6
Akademický článek
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Autor:
Min Zhao, Lijun Fu, Yan Chai, Meng Sun, Yan Li, Shuo Wang, Jianxun Qi, Bin Zeng, Le Kang, George F. Gao, Shuguang Tan
Publikováno v:
Cell Reports, Vol 36, Iss 12, Pp 109734- (2021)
Summary: Glucocorticoid-induced tumor necrosis factor receptor family-related protein (GITR) is a critical regulatory molecule in modulation of T cell immune responses. Here we report the mouse GITR (mGITR) and mGITR ligand (mGITRL) complex structure
Externí odkaz:
https://doaj.org/article/c125f73345ce4bf2b88a68c053d1f1b9
Autor:
David M. Richards, Viola Marschall, Katharina Billian-Frey, Karl Heinonen, Christian Merz, Mauricio Redondo Müller, Julian P. Sefrin, Matthias Schröder, Jaromir Sykora, Harald Fricke, Oliver Hill, Christian Gieffers, Meinolf Thiemann
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 7, Iss 1, Pp 1-13 (2019)
Abstract Background Glucocorticoid-induced TNFR-related protein (TNFRSF18, GITR, CD357), expressed by T cells, and its ligand (TNFSF18, GITRL), expressed by myeloid populations, provide co-stimulatory signals that boost T cell activity. Due to the im
Externí odkaz:
https://doaj.org/article/04921d3723f8400dab5dcc210d3292d0
Publikováno v:
Journal of Translational Medicine, Vol 17, Iss 1, Pp 1-10 (2019)
Abstract Background Helios is important for functional and phenotype stability of regulatory T cells (Tregs). However, the role of Helios in autoimmune diseases and its regulation remains unclear. This study aimed to investigate the role of Helios+ T
Externí odkaz:
https://doaj.org/article/7d964fe359514bab9118620fba6be325
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Glucocorticoid-induced TNFR-related protein (GITR) is a member of the TNFR superfamily which is expressed in various cells, including T cells, natural killer cells and some myeloid cells. GITR is activated by its ligand, GITRL, mainly expressed on an
Externí odkaz:
https://doaj.org/article/890861fcb09b45c3b0257b7c143106e0
Autor:
Fengxia Ding, Bo Liu, Chao Niu, Ting Wang, Yaping Wang, Gang Geng, Daiyin Tian, Jihong Dai, Zhou Fu
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
The mechanism(s) underlying endotoxin tolerance in asthma remain elusive. As the endotoxin lipopolysaccharide (LPS) affects the expression of the regulatory T-cell (Treg)-suppressive glucocorticoid-induced tumor necrosis factor receptor ligand (GITRL
Externí odkaz:
https://doaj.org/article/160d64c0493248bca8755473f9533eaa
Autor:
Kübra Kaban, Sarah M. Greiner, Samuel Holzmayer, Claudia Tandler, Sophie Meyer, Clemens Hinterleitner, Helmut R. Salih, Melanie Märklin, Jonas S. Heitmann
Publikováno v:
Diagnostics, Vol 11, Iss 11, p 2041 (2021)
Recent success of novel therapies has improved treatment of chronic lymphocytic leukemia (CLL) patients, but most of them still require several treatment regimes. To improve treatment choice, prognostic markers suitable for prediction of disease outc
Externí odkaz:
https://doaj.org/article/48045c6f277e48eea4ecfe0855fc7d48
Autor:
Nick M. Durham, Nick Holoweckyj, Randall S. MacGill, Kelly McGlinchey, Ching Ching Leow, Scott H. Robbins
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 5, Iss 1, Pp 1-12 (2017)
Abstract Background The expansion of antigen-specific CD8 T cells is important in generating an effective and long-lasting immune response to tumors and viruses. Glucocorticoid-induced tumor necrosis factor receptor family-related receptor (GITR) is
Externí odkaz:
https://doaj.org/article/c0411b30dc4c45a186da0ada7b815816