Antinociceptive profile of potent opioid peptide AM94, a fluorinated analogue of biphalin with non-hydrazine linker

Autor: F. Pinnen, Stefano Pieretti, Azzurra Stefanucci, Gino Lucente, Stefano Fidanza, Roberto Costante, Adriano Mollica

Publikováno v: Journal of Peptide Science. 19:233-239

AM94 is a fluorinated analog of biphalin with non-hydrazine linker that has an in vitro affinity for μ-opioid and δ-opioid receptors tenfold higher than biphalin. Furthermore, in vivo evaluation in rats showed that AM94 has in hot plate test – af

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2feffc6aa9c9566168ebd76cc63b5cfd
https://doi.org/10.1002/psc.2465

The cis-4-Amino-l-proline Residue as a Scaffold for the Synthesis of Cyclic and Linear Endomorphin-2 Analogues

Autor: Frank Porreca, Anatoly P. Sobolev, Azzurra Stefanucci, Cristina Campestre, Peg Davis, Victor J. Hruby, F. Pinnen, Adriano Mollica, Luisa Mannina, Federica Feliciani, Shou Wu Ma, Gino Lucente, Josephine Lai

Publikováno v: Journal of medicinal chemistry (Online) 55 (2012): 3027–3035. doi:10.1021/jm201402v
info:cnr-pdr/source/autori:A. Mollica, F. Pinnen, A. Stefanucci, F. Feliciani, C. Campestre, L. Mannina, A. P. Sobolev, G. Lucente, P. Davis, J. Lai, S.-W. Ma, F. Porreca, V. J. Hruby/titolo:The cis-4-amino-L-proline residue as a scaffold for the synthesis of cyclic and linear endomorphin-2 analogues/doi:10.1021%2Fjm201402v/rivista:Journal of medicinal chemistry (Online)/anno:2012/pagina_da:3027/pagina_a:3035/intervallo_pagine:3027–3035/volume:55

Endomorphin-2 (EM-2: Tyr-Pro-Phe-Phe-NH(2)) is an endogenous tetrapeptide that combines potency and efficacy with high affinity and selectivity toward the μ opioid receptor, the most responsible for analgesic effects in the central nervous system. T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::919a860e973eece86632e87c29dc37b2
https://doi.org/10.1021/jm201402v

Synthetic and Electrochemical Studies of [2Fe2S] Complexes Containing a 4‐Amino‐1,2‐dithiolane‐4‐carboxylic Acid Moiety

Autor: Ulf-Peter Apfel, Christian R. Kowol, Enrico Morera, Wolfgang Weigand, Bernhard K. Keppler, Gino Lucente, Helmar Görls

Publikováno v: European Journal of Inorganic Chemistry. 2010:5079-5086

In the search for novel [FeFe] hydrogenase model systems several di- and tripeptides containing an 4-amino-1,2-dithiolane-4-carboxylic acid (Adt) moiety or N-phenylsulfonyl-Adt-OMe were treated with Fe 3 (CO)1 2. The resulting [FeFe] complexes were c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b34b20718871c5c352a7a1af3c441869
https://doi.org/10.1002/ejic.201000619

Investigation of amino acid containing [FeFe] hydrogenase models concerning pendant base effects

Autor: Enrico Morera, Johannes G. Vos, Wolfgang Weigand, Gino Lucente, Yvonne Halpin, Bernhard K. Keppler, Helmar Görls, Joachim Kübel, Ulf-Peter Apfel, Florian Kloss, Christian R. Kowol

Publikováno v: Journal of Inorganic Biochemistry. 103:1236-1244

The present investigations deal with the modeling of the peptide surrounding of [FeFe] hydrogenase using amine containing disulphides to simulate possible influences of the amino acid lysine (K237) on the electrochemical and electrocatalytic properti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9058bcff90e9bfcece3408694e357d8a
https://doi.org/10.1016/j.jinorgbio.2009.07.005

N-acyl-diketopiperazines

Autor: Silvio Cerrini, Walter Fedeli, Giancarlo Zanotti, Fernando Mazza, Francesco Pinnen, Gino Lucente

Publikováno v: International Journal of Peptide and Protein Research. 23:223-229

N-(N-phenylacetyl-L-alanyl)-cyclo-(L-phenylalanyl-D-prolyl) (I) was synthesized in one step starting from the linear precursor phenylacetyl-L-alanyl-L-phenyl-alanyl-L-proline. X-ray crystallographic analysis of (I) shows that the diketopiperazine rin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a6154d161293c8ac8ae35df455dec0fc
https://doi.org/10.1111/j.1399-3011.1984.tb02713.x