Výsledky vyhledávání - "GIANNINO DEL SAL"

Akademický článek

Emerin mislocalization during chromatin bridge resolution can drive prostate cancer cell invasiveness in a collagen-rich microenvironment

Publikováno v: Experimental and Molecular Medicine, Vol 56, Iss 9, Pp 2016-2032 (2024)

Abstract Micronuclei (MN) can form through many mechanisms, including the breakage of aberrant cytokinetic chromatin bridges. The frequent observation of MN in tumors suggests that they might not merely be passive elements but could instead play acti

Externí odkaz: https://doaj.org/article/9049f0d54f1e45df92a10d86919ba729

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Akademický článek

ALCAM-mediated cDC1 CD8 T cells interactions are suppressed in advanced lung tumors

Autor: Luciano G. Morosi, Giulia M. Piperno, Lucía López, Roberto Amadio, Sonal Joshi, Alessandra Rustighi, Giannino Del Sal, Federica Benvenuti

Publikováno v: OncoImmunology, Vol 13, Iss 1 (2024)

Conventional type 1 dendritic cells (cDC1) are critical regulators of anti-tumoral T-cell responses. The structure and abundance of intercellular contacts between cDC1 and CD8 T cells in cancer tissues is important to determine the outcome of the T-c

Externí odkaz: https://doaj.org/article/c26f54c4f1384cff8d47264b180e0d57

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Akademický článek

NOTCH localizes to mitochondria through the TBC1D15-FIS1 interaction and is stabilized via blockade of E3 ligase and CDK8 recruitment to reprogram tumor-initiating cells

Autor: Hye Yeon Choi, Yicheng Zhu, Xuyao Zhao, Simran Mehta, Juan Carlos Hernandez, Jae-Jin Lee, Yi Kou, Risa Machida, Mauro Giacca, Giannino Del Sal, Ratna Ray, Hyungjin Eoh, Stanley M. Tahara, Lin Chen, Hidekazu Tsukamoto, Keigo Machida

Publikováno v: Experimental and Molecular Medicine, Vol 56, Iss 2, Pp 461-477 (2024)

Abstract The P53-destabilizing TBC1D15-NOTCH protein interaction promotes self-renewal of tumor-initiating stem-like cells (TICs); however, the mechanisms governing the regulation of this pathway have not been fully elucidated. Here, we show that TBC

Externí odkaz: https://doaj.org/article/cce91a31632d430a830e45249520ef25

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Akademický článek

EMID2 is a novel biotherapeutic for aggressive cancers identified by in vivo screening

Publikováno v: Journal of Experimental & Clinical Cancer Research, Vol 43, Iss 1, Pp 1-14 (2024)

Abstract Background New drugs to tackle the next pathway or mutation fueling cancer are constantly proposed, but 97% of them are doomed to fail in clinical trials, largely because they are identified by cellular or in silico screens that cannot predi

Externí odkaz: https://doaj.org/article/a789156b8a0b44008d091dcfb970d332

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Akademický článek

Mutant p53 sustains serine-glycine synthesis and essential amino acids intake promoting breast cancer growth

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-21 (2023)

Abstract Reprogramming of amino acid metabolism, sustained by oncogenic signaling, is crucial for cancer cell survival under nutrient limitation. Here we discovered that missense mutant p53 oncoproteins stimulate de novo serine/glycine synthesis and

Externí odkaz: https://doaj.org/article/ed8691094df743f6a79d37fb5d803a8a

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Akademický článek

TGS1 mediates 2,2,7-trimethyl guanosine capping of the human telomerase RNA to direct telomerase dependent telomere maintenance

Autor: Valentina Buemi, Odessa Schillaci, Mariangela Santorsola, Deborah Bonazza, Pamela Veneziano Broccia, Annie Zappone, Cristina Bottin, Giulia Dell’Omo, Sylvie Kengne, Stefano Cacchione, Grazia Daniela Raffa, Silvano Piazza, Fabrizio d’Adda di Fagagna, Roberta Benetti, Maurizio Cortale, Fabrizio Zanconati, Giannino Del Sal, Stefan Schoeftner

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)

Telomerase protects chromosome ends in stem cells and cancer cells. Here the authors show that Trimethylguaonsine Synthase 1 (TGS-1) – dependent trimethylguanosine capping of the RNA component of the human telomerase complex has an important role i

Externí odkaz: https://doaj.org/article/695aa97a2df5484da202dfc53c1f242a

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Akademický článek

A mutant p53/Hif1α/miR-30d axis reprograms the secretory pathway promoting the release of a prometastatic secretome

Autor: Valeria Capaci, Fiamma Mantovani, Giannino Del Sal

Publikováno v: Cell Stress, Vol 4, Iss 11, Pp 261-264 (2020)

TP53 missense mutations are frequent driver events during tumorigenesis. The majority of TP53 mutations are missense and occur within the DNA binding domain of p53, leading to expression of mutant p53 (mut-p53) proteins that not only lose the tumor s

Externí odkaz: https://doaj.org/article/24457a72196445c9a7f9bfe3c5d80ecb

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Akademický článek

Mutant p53 induces Golgi tubulo-vesiculation driving a prometastatic secretome

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-19 (2020)

p53 mutants can promote tumorigenesis by affecting fundamental cellular pathways and functions. In this study, the authors demonstrate a novel mutant-p53/HIF1α/miR-30d axis that impacts Golgi structure, trafficking, and secretion of proteins essenti

Externí odkaz: https://doaj.org/article/97f4b2fef7914489a6cce6c57fdc9e48

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