Zobrazeno 1 - 10
of 164
pro vyhledávání: '"GHADA S. HASSAN"'
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Metabolic dysfunction-associated steatotic liver disease (MASLD) comprises a spectrum of liver diseases that span simple steatosis, metabolic dysfunction-associated steatohepatitis (MASH) and fibrosis and may progress to cirrhosis and cancer. The pat
Externí odkaz:
https://doaj.org/article/32afe896c7434366bda4aa6767a32830
Publikováno v:
Cells, Vol 13, Iss 19, p 1621 (2024)
CD154, also known as CD40 ligand, is a costimulatory molecule involved in humoral and adaptive immune responses upon pairing with its classical receptor, CD40. The CD154/CD40 dyad is a key participant in the pathogenesis of many autoimmune diseases,
Externí odkaz:
https://doaj.org/article/dba2cc506a474d07820e4d23837e8c67
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
The liver is situated at the interface of the gut and circulation where it acts as a filter for blood-borne and gut-derived microbes and biological molecules, promoting tolerance of non-invasive antigens while driving immune responses against pathoge
Externí odkaz:
https://doaj.org/article/65ebd56d94f9462fa936bdf808758246
Publikováno v:
ACS Omega, Vol 6, Iss 29, Pp 19202-19211 (2021)
Externí odkaz:
https://doaj.org/article/0b0c5b0886a84048ba138d093d065ce3
Autor:
Manuel Flores Molina, Mohamed N. Abdelnabi, Sabrina Mazouz, Deborah Villafranca-Baughman, Vincent Quoc-Huy Trinh, Shafi Muhammad, Nathalie Bédard, David Osorio Laverde, Ghada S. Hassan, Adriana Di Polo, Naglaa H. Shoukry
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Macrophages are key regulators of inflammation and repair, but their heterogeneity and multiple roles in the liver are not fully understood. We aimed herein to map the intrahepatic macrophage populations and their function(s) during acute liver injur
Externí odkaz:
https://doaj.org/article/1a9adf263d8c472bbe8fcd4f23c43a10
Autor:
Sara T. Al-Rashood, Ahmed R. Hamed, Ghada S. Hassan, Hamad M. Alkahtani, Abdulrahman A. Almehizia, Amal Alharbi, Mohammad M. Al-Sanea, Wagdy M. Eldehna
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 831-839 (2020)
In the current medical era, spirooxindole motif stands out as a privileged heterospirocyclic scaffold that represents the core for a wide range of bioactive naturally isolated products (such as Strychnofoline and spirotryprostatins A and B) and synth
Externí odkaz:
https://doaj.org/article/983b0fe855ce4714847e8d2cfcc692d8
Autor:
Heba Elmansi, Jenny Jeehan Nasr, Azza H. Rageh, Mohamed I. El-Awady, Ghada S. Hassan, Hatem A. Abdel-Aziz, Fathalla Belal
Publikováno v:
BMC Chemistry, Vol 13, Iss 1, Pp 1-7 (2019)
Abstract Background Lipophilicity is a physicochemical property of an essential importance in medicinal chemistry; therefore, fast and reliable measurement of lipophilicity will affect greatly the drug discovery process. Results A series of N-benzene
Externí odkaz:
https://doaj.org/article/6270a92b98934d38a83ab43b37465f7c
Autor:
Wagdy M. Eldehna, Ghada S. Hassan, Sara T. Al-Rashood, Tarfah Al-Warhi, Ahmed E. Altyar, Hamad M. Alkahtani, Abdulrahman A. Almehizia, Hatem A. Abdel-Aziz
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 34, Iss 1, Pp 322-332 (2019)
In connection with our research program on the development of novel anticancer candidates, herein we report the design and synthesis of novel series of 1-(2-methyl-6-arylpyridin-3-yl)-3-phenylureas 5a–l. The target pyridins were evaluated for their
Externí odkaz:
https://doaj.org/article/5421ae20766641a986c4b1316e45abac
Publikováno v:
Cells, Vol 11, Iss 11, p 1747 (2022)
CD154, an inflammatory mediator also known as CD40 ligand, has been identified as a novel binding partner for some members of the integrin family. The αIIbβ3, specifically expressed on platelets, was the first integrin to be described as a receptor
Externí odkaz:
https://doaj.org/article/352b03748b814e86ac3849615da86275
Publikováno v:
PLoS ONE, Vol 15, Iss 8, p e0235753 (2020)
CD154 plays a major role in the pathogenesis of several autoimmune and inflammatory diseases. In addition to CD40, soluble CD154 (sCD154) binds to other receptors namely αIIbβ3, αMβ2, α5β1 and αvβ3 integrins. We have previously reported that
Externí odkaz:
https://doaj.org/article/fd469f314e614640b78c59e1b62ef938