Zobrazeno 1 - 10
of 166
pro vyhledávání: '"GFI1B"'
Publikováno v:
Platelets, Vol 34, Iss 1 (2023)
Although thrombocytopenia in neonatal intensive care patients is rarely due to inherited disorders, the number of genetic variants implicated in platelet defects has grown dramatically with increasing genome-wide sequencing. Here we describe a case o
Externí odkaz:
https://doaj.org/article/06cf91f3484d47a28c35620d6f40d21e
Autor:
Nanna Brøns, Carlo Zaninetti, Sisse Rye Ostrowski, Jesper Petersen, Andreas Greinacher, Maria Rossing, Eva Leinøe
Publikováno v:
Platelets, Vol 32, Iss 5, Pp 701-704 (2021)
Genetic variants in growth factor-independent 1B (GFI1B), encoding transcription factor GFI1B, are causative of platelet-type bleeding disorder-17. Presently, 53 cases of GFI1B associated inherited thrombocytopenia (IT) have been published, however o
Externí odkaz:
https://doaj.org/article/d41c21d71e054f66afbe48257970edb5
Autor:
Hugues Beauchemin, Tarik Möröy
Publikováno v:
Frontiers in Genetics, Vol 11 (2020)
Growth factor independence 1 (GFI1) and the closely related protein GFI1B are small nuclear proteins that act as DNA binding transcriptional repressors. Both recognize the same consensus DNA binding motif via their C-terminal zinc finger domains and
Externí odkaz:
https://doaj.org/article/43e9299c4eb4412b96b73bbb770e28ca
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Autor:
Masao Tsukada, Yasunori Ota, Adam C. Wilkinson, Hans J. Becker, Motomi Osato, Hiromitsu Nakauchi, Satoshi Yamazaki
Publikováno v:
Stem Cell Reports, Vol 9, Iss 4, Pp 1024-1033 (2017)
Generation of hematopoietic stem cells (HSCs) from pluripotent stem cells (PSCs) could potentially provide unlimited HSCs for clinical transplantation, a curative treatment for numerous blood diseases. However, to date, bona fide HSC generation has b
Externí odkaz:
https://doaj.org/article/af68468d5f2a4405aa1d7b7746bf555f
Autor:
Natthapol Songdej, A. Koneti Rao
Publikováno v:
Platelets, Vol 28, Iss 1, Pp 20-26 (2017)
Transcription factors (TFs) are proteins that bind to specific DNA sequences and regulate expression of genes. The molecular and genetic mechanisms in most patients with inherited platelet dysfunction are unknown. There is now increasing evidence tha
Externí odkaz:
https://doaj.org/article/7eaf76bb16fe41b2946b4dcc3532a47d
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Publikováno v:
Frontiers in Oncology, Vol 9 (2019)
One of the hallmarks of acute myeloid leukemia (AML) is a block in cellular differentiation. Recent studies have shown that small molecules targeting Lysine Specific Demethylase 1A (KDM1A) may force the malignant cells to terminally differentiate. KD
Externí odkaz:
https://doaj.org/article/83e6c73803184636bb3bd8b25688da2f
Autor:
Faleschini, Michela, Papa, Nicole, Morel-Kopp, Marie-Christine, Marconi, Caterina, Giangregorio, Tania, Melazzini, Federica, Bozzi, Valeria, Seri, Marco, Noris, Patrizia, Pecci, Alessandro, Savoia, Anna, Bottega, Roberta
Publikováno v:
Haematologica
GFI1B is a transcription factor essential for the regulation of erythropoiesis and megakaryopoiesis, and pathogenic variants have been associated with thrombocytopenia and bleeding. Analysing thrombocytopenic families by whole exome sequencing, we id
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::b9bb4cf0345246c888decc3dbb05dad2
http://hdl.handle.net/11562/1064491
http://hdl.handle.net/11562/1064491
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.