Zobrazeno 1 - 10
of 327
pro vyhledávání: '"GERHARD GIEBISCH"'
Publikováno v:
Gut and Liver, Vol 10, Iss 6, Pp 881-889 (2016)
Potassium channels and transporters maintain potassium homeostasis and play significant roles in several different biological actions via potassium ion regulation. In previous decades, the key revelations that potassium channels and transporters are
Externí odkaz:
https://doaj.org/article/b269a07239d749f9ba4428124b376b7d
Publikováno v:
Chemical Engineering Transactions, Vol 48 (2016)
Is a displacement of the self-ignition temperature up to higher temperatures possible by a pressure reduction? Therefore, the influence of an air pressure reduction on the self-ignition temperature of dust bulks is investigated. First, major effects
Externí odkaz:
https://doaj.org/article/bd2a221ace444f1c940f880912752eac
Publikováno v:
Gut and Liver
Potassium channels and transporters maintain potassium homeostasis and play significant roles in several different biological actions via potassium ion regulation. In previous decades, the key revelations that potassium channels and transporters are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28c3980d74d7c73c4ee70034effa1581
http://europepmc.org/articles/PMC5087926
http://europepmc.org/articles/PMC5087926
Autor:
Qingshang Yan, Wen-Hui Wang, Junhua Guo, Haiyan Hu, Ke Dong, Steven C. Hebert, Ming Lu, Laxiang Wan, Emile L. Boulpaep, Gerhard Giebisch, Tong Wang
Publikováno v:
Journal of Biological Chemistry. 291:5259-5269
Romk knock-out mice show a similar phenotype to Bartter syndrome of salt wasting and dehydration due to reduced Na-K-2Cl-cotransporter activity. At least three ROMK isoforms have been identified in the kidney; however, unique functions of any of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13bb6cfd234681db85f560cf93269424
https://doi.org/10.1074/jbc.m115.707877
https://doi.org/10.1074/jbc.m115.707877
Autor:
Gerhard Giebisch, Robert J. Alpern
[][1] On April 25, 2018, Dr. Donald Seldin passed away at the age of 97, and the world lost a great treasure. Born in Coney Island, Brooklyn, Seldin attended James Madison High School and established his intellectual roots early on. He then attended
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2d079f08ac8ac535990e916e22e009a
https://europepmc.org/articles/PMC6065072/
https://europepmc.org/articles/PMC6065072/
Autor:
Lijun Wang, Gerhard Giebisch, Chengbiao Zhang, Richard P. Lifton, Junhui Zhang, Wen-Hui Wang, Ute I. Scholl, Dao-Hong Lin, Xiao-Tong Su
Publikováno v:
Proceedings of the National Academy of Sciences. 111:11864-11869
The renal phenotype induced by loss-of-function mutations of inwardly rectifying potassium channel (Kir), Kcnj10 (Kir4.1), includes salt wasting, hypomagnesemia, metabolic alkalosis and hypokalemia. However, the mechanism by which Kir.4.1 mutations c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c0d19e981355246aa69298a6b3fd768
https://doi.org/10.1073/pnas.1411705111
https://doi.org/10.1073/pnas.1411705111
Autor:
Gerhard Giebisch, Charles S. Wingo
Publikováno v:
Seminars in Nephrology. 33:209-214
During the past century, investigators have increased our understanding of renal potassium excretion significantly using many techniques. Notable among these were renal clearance experiments, renal micropuncture, isolated tubule microperfusion, and e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8b71b508e6f0352f7dcd470a4a9e7df
https://doi.org/10.1016/j.semnephrol.2013.05.001
https://doi.org/10.1016/j.semnephrol.2013.05.001
Autor:
Nilufar Mohebbi, Dennis Brown, Ulrike Uhlig, John P. Geibel, Gerhard Giebisch, Carsten A. Wagner, Sylvie Breton
Publikováno v:
Cellular Physiology and Biochemistry. 28:513-520
Intercalated cells in the collecting duct system express V-type H+-ATPases which participate in acid extrusion, bicarbonate secretion, and chloride absorption depending on the specific subtype. The activity of H+-ATPases is regulated by acid-base sta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a06eccd9570c2dc6222e6ac44a5952dd
https://doi.org/10.1159/000335112
https://doi.org/10.1159/000335112
Publikováno v:
Proceedings of the National Academy of Sciences. 107:6082-6087
The cystic fibrosis transmembrane conductance regulator (CFTR) is expressed in many segments of the mammalian nephron, where it may interact with and modulate the activity of a variety of apical membrane proteins, including the renal outer medullary
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13eee38c5500761e6c8311045b41d95f
https://doi.org/10.1073/pnas.0902661107
https://doi.org/10.1073/pnas.0902661107
Autor:
Ze-Guang Han, Peng Yue, Dao-Hong Lin, Chu-Yang Pan, Michael J. Caplan, Wen-Hui Wang, Gerhard Giebisch, Peng Sun, Xin Zhang, Marcel Roos
Publikováno v:
Journal of Biological Chemistry. 284:29614-29624
POSH (plenty of SH3) is a scaffold protein that has been shown to act as an E3 ubiquitin ligase. Here we report that POSH stimulates the ubiquitination of Kir1.1 (ROMK) and enhances the internalization of this potassium channel. Immunostaining reveal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e53c55b9b1eb20f923a08044fcf93274
https://doi.org/10.1074/jbc.m109.041582
https://doi.org/10.1074/jbc.m109.041582