Zobrazeno 1 - 10
of 131
pro vyhledávání: '"GERALD WEEKS"'
Autor:
Alex Chattwood, Koki Nagayama, Parvin Bolourani, Lauren Harkin, Marzieh Kamjoo, Gerald Weeks, Christopher RL Thompson
Publikováno v:
eLife, Vol 2 (2013)
In cell culture, genetically identical cells often exhibit heterogeneous behavior, with only ‘lineage primed’ cells responding to differentiation inducing signals. It has recently been proposed that such heterogeneity exists during normal embryon
Externí odkaz:
https://doaj.org/article/182e9c597f2a40979bcd67c3f1d9d68b
This new Handbook of Family Therapy is the culmination of a decade of achievements within the field of family and couples therapy, emerging from and celebrating the dynamic evolution of marriage and family theory, practice, and research. The editors
Autor:
Steven P. Briggs, Gerald Weeks, Arjan Kortholt, Peter J.M. van Haastert, Nieves M Montaño, Pouya Lotfi, Zhouxin Shen, Henderikus Pots, Parvin Bolourani, Anita J Chavan, Pascale G. Charest, Ankita Khanna
Publikováno v:
Scientific Reports, 6:25823, 1-9. Nature Publishing Group
Scientific Reports
Scientific Reports
Target of Rapamycin Complex 2 (TORC2) has conserved roles in regulating cytoskeleton dynamics and cell migration and has been linked to cancer metastasis. However, little is known about the mechanisms regulating TORC2 activity and function in any sys
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2db9c212e730f9c40a02abe16cb66b1f
https://doi.org/10.1038/srep25823
https://doi.org/10.1038/srep25823
Publikováno v:
Journal of Biological Chemistry. 285:41374-41379
RasC is required for optimum activation of adenylyl cyclase A and for aggregate stream formation during the early differentiation of Dictyostelium discoideum. RasG is unable to substitute for this requirement despite its sequence similarity to RasC.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be7b973fd0a5648126980916b89888b3
https://doi.org/10.1074/jbc.m110.181115
https://doi.org/10.1074/jbc.m110.181115
Autor:
Arjan Kortholt, Peter J.M. van Haastert, Ineke Keizer-Gunnink, Alfred Wittinghofer, Holger Rehmann, Parvin Bolourani, Gerald Weeks
Publikováno v:
Molecular Biology of the Cell, 21(6), 936-945. AMER SOC CELL BIOLOGY
GbpD, a Dictyostelium discoideum guanine exchange factor specific for Rap1, has been implicated in adhesion, cell polarity, and chemotaxis. Cells overexpressing GbpD are flat, exhibit strongly increased cell-substrate attachment, and extend many bifu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2f7513b2246f1bda092955c8cde5207
https://research.rug.nl/en/publications/bf8021f1-84fc-4a00-8281-c0d9e0024e5c
https://research.rug.nl/en/publications/bf8021f1-84fc-4a00-8281-c0d9e0024e5c
Autor:
Robert R. Kay, Nicola L. Aldren, Christopher R. L. Thompson, David Traynor, Gerald Weeks, Katie Parkinson, Parvin Bolourani
Publikováno v:
Journal of Cell Science. 122:335-344
Regulated cell adhesion and motility have important roles during growth, development and tissue homeostasis. Consequently, great efforts have been made to identify genes that control these processes. One candidate is Rap1, as it has been implicated i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22e05ec0712952436dfb687144472b10
https://doi.org/10.1242/jcs.036822
https://doi.org/10.1242/jcs.036822
Publikováno v:
The Journal of Cell Biology
Spatial and temporal regulation of Rap1 is required for proper myosin assembly and cell adhesion during cell migration in Dictyostelium discoideum. Here, we identify a Rap1 guanosine triphosphatase–activating protein (GAP; RapGAP1) that helps media
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18c951e7d7b57871fea231626754687a
https://doi.org/10.1083/jcb.200705068
https://doi.org/10.1083/jcb.200705068
Publikováno v:
The Journal of Cell Biology
We have investigated the role of Rap1 in controlling chemotaxis and cell adhesion in Dictyostelium discoideum. Rap1 is activated rapidly in response to chemoattractant stimulation, and activated Rap1 is preferentially found at the leading edge of che
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4e2e0ddd9e56f767da235bfe656b08a
http://europepmc.org/articles/PMC2064086
http://europepmc.org/articles/PMC2064086
Publikováno v:
Developmental Biology. 284:412-420
The disruption of the gene encoding the Dictyostelium Ras subfamily protein, RasC results in a strain that fails to aggregate with defects in both cAMP signal relay and chemotaxis. Restriction enzyme mediated integration disruption of a second gene i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::959dec333c97cf6f382e53f9cfc47fcf
https://doi.org/10.1016/j.ydbio.2005.05.037
https://doi.org/10.1016/j.ydbio.2005.05.037
Autor:
Gerald Weeks, George B. Spiegelman, David Secko, Chinten James Lim, Meenal Khosla, Karl A. Zawadzki
Publikováno v:
Experimental Cell Research. 306:47-55
In addition to its previously established roles in cAMP relay and cAMP chemotaxis, loss of signal transduction through the RasC protein was found to impact a number of vegetative cell functions. Vegetative rasC- cells exhibited reduced random motilit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7c5666722f927cc56891fe4449ab9e6
https://doi.org/10.1016/j.yexcr.2005.02.002
https://doi.org/10.1016/j.yexcr.2005.02.002