Abrogation of USP7 is an alternative strategy to downregulate PD-L1 and sensitize gastric cancer cells to T cells killing

Autor: Yi-Chao Zheng, Hong-Min Liu, Ouwen Li, Jun-Wei Wang, Zhenhe Suo, Fengyu Qi, Wen-Ting Kang, Pengxing He, Zhi-Ru Wang, Yinghua You

Publikováno v: Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 11, Iss 3, Pp 694-707 (2021)

Targeting immune checkpoints such as programmed cell death protein 1 (PD-1) and programmed death ligand-1 (PD-L1) have been approved for treating melanoma, gastric cancer (GC) and bladder cancer with clinical benefit. Nevertheless, many patients fail

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad3f6e9de03bb3ad460a61d5471e4bca
http://europepmc.org/articles/PMC7982505

ALDH2 Repression Promotes Lung Tumor Progression via Accumulated Acetaldehyde and DNA Damage1

Autor: Li, Kaimi, Guo, Wenzheng, Li, Zhanming, Wang, Yang, Sun, Beibei, Xu, Dongliang, Ling, Jing, Song, Hongyong, Liao, Yueling, Wang, Tong, Jing, Bo, Hu, Min, Kuang, Yanbin, Wang, Qi, Yao, Feng, Sun, Aijun, Zhu, Liang, Wang, Lishun, Deng, Jiong

Publikováno v: Neoplasia (New York, N.Y.)

The major role of aldehyde dehydrogenase 2 family (ALDH2) is to detoxify acetaldehyde (ACE) to non-toxic acetic acid. Many evidences suggest that ALDH2 dysfunction contributes to a variety of human diseases including cancer. However, the biological f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::bf36cb8f51f02bd677e7582917ea8a57
http://europepmc.org/articles/PMC6506700

Tristetraprolin Promotes Hepatic Inflammation and Tumor Initiation but Restrains Cancer Progression to Malignancy

Autor: Michelangelo Foti, Olivia Bejuy, Christine Maeder, Marta Correia de Sousa, Monika Gjorgjieva, Claudio De Vito, Laura Rubbia-Brandt, Dobrochna Dolicka, Margot Fournier, Cyril Sobolewski, Didier J. Colin, Flavien Berthou, Perry J. Blackshear

Publikováno v: Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology (2020)

Background & Aims Tristetraprolin (TTP) is a key post-transcriptional regulator of inflammatory and oncogenic transcripts. Accordingly, TTP was reported to act as a tumor suppressor in specific cancers. Herein, we investigated how TTP contributes to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e04acdfadc7dd7cf24b47a30be60cc1a
https://pubmed.ncbi.nlm.nih.gov/32987153

Identification of a novel PAK1 inhibitor to treat pancreatic cancer

Autor: Lingxia Zhu, Peng Cao, Yonghua Zhu, Jiao Chen, Rafael Rosell, Yuhan Yang, Chunping Hu, Xiaoyan Sun, Xueting Cai, Jiayu Zhao, Yang Yang, Jiaqi Wang

Publikováno v: Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 10, Iss 4, Pp 603-614 (2020)

Pancreatic cancer is one of the most aggressive cancers with poor prognosis and a low 5-year survival rate. The family of P21-activated kinases (PAKs) appears to modulate many signaling pathways that contribute to pancreatic carcinogenesis. In this w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0913dd0c804696dd82046e2f7cdf6b50
https://pubmed.ncbi.nlm.nih.gov/32322465

Identification and verification of eight cancer-associated fibroblasts related genes as a prognostic signature for head and neck squamous cell carcinoma.

Autor: Dong L; Department of Otorhinolaryngology Head and Neck Surgery, Yantai Yuhuangding Hospital, Shandong University, China.; Shandong Provincial Clinical Research Center for Otorhinolaryngologic Diseases., Sun Q; Department of Otorhinolaryngology Head and Neck Surgery, Yantai Yuhuangding Hospital, Shandong University, China.; Shandong Provincial Clinical Research Center for Otorhinolaryngologic Diseases., Song F; Department of Otorhinolaryngology Head and Neck Surgery, Yantai Yuhuangding Hospital, Shandong University, China.; Shandong Provincial Clinical Research Center for Otorhinolaryngologic Diseases., Song X; Department of Otorhinolaryngology Head and Neck Surgery, Yantai Yuhuangding Hospital, Shandong University, China.; Shandong Provincial Clinical Research Center for Otorhinolaryngologic Diseases., Lu C; Department of Otorhinolaryngology Head and Neck Surgery, Yantai Yuhuangding Hospital, Shandong University, China.; Shandong Provincial Clinical Research Center for Otorhinolaryngologic Diseases., Li Y; Department of Otorhinolaryngology Head and Neck Surgery, Yantai Yuhuangding Hospital, Shandong University, China.; Shandong Provincial Clinical Research Center for Otorhinolaryngologic Diseases., Song X; Department of Otorhinolaryngology Head and Neck Surgery, Yantai Yuhuangding Hospital, Shandong University, China.; Shandong Provincial Clinical Research Center for Otorhinolaryngologic Diseases.

Publikováno v: Heliyon [Heliyon] 2023 Feb 28; Vol. 9 (3), pp. e14003. Date of Electronic Publication: 2023 Feb 28 (Print Publication: 2023).